3EPI

Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine and incoming TTP

Summary for 3EPI

• Entry DOI: 10.2210/pdb3epi/pdb
• Related: 2ALZ 2FLP 3epg
• Descriptor: DNA polymerase iota, 5'-D(*DTP*DCP*DTP*(2EG)P*DGP*DGP*DGP*DTP*DCP*DCP*DTP*DAP*DGP*DGP*DAP*DCP*DCP*(DOC))-3', SODIUM ION, ... (5 entities in total)
• Functional Keywords: dna pol iota, lesion bypass, n2-ethylguanine, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, magnesium, metal-binding, mutator protein, nucleotidyltransferase, nucleus, schiff base, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9UNA4
• Total number of polymer chains: 3
• Total formula weight: 58186.52

Authors

Pence, M.G. (deposition date: 2008-09-29, release date: 2008-12-16, Last modification date: 2023-09-06)

• Primary citation: Pence, M.G.,Blans, P.,Zink, C.N.,Hollis, T.,Fishbein, J.C.,Perrino, F.W.; Lesion bypass of N2-ethylguanine by human DNA polymerase iota.; J.Biol.Chem., 284:1732-1740, 2009; PubMed: 18984581; DOI: 10.1074/jbc.M807296200

Experimental method

X-RAY DIFFRACTION (2.9 Å)