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6X6C
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BU of 6x6c by Molmil
Cryo-EM structure of NLRP1-DPP9-VbP complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6X6A
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BU of 6x6a by Molmil
Cryo-EM structure of NLRP1-DPP9 complex
Descriptor: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
Authors:Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
Deposit date:2020-05-27
Release date:2021-03-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
7T9X
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BU of 7t9x by Molmil
Saccharomyces cerevisiae Pex12 RING domain
Descriptor: Peroxisome assembly protein 12, ZINC ION
Authors:Feng, P, Rapoport, T.
Deposit date:2021-12-20
Release date:2022-06-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Nature, 607, 2022
7T92
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BU of 7t92 by Molmil
Structure of the peroxisomal retro-translocon formed by a heterotrimeric ubiquitin ligase complex
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Fab heavy chain, ...
Authors:Peiqiang, F, Tom, R.
Deposit date:2021-12-17
Release date:2022-07-06
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Nature, 607, 2022
7TMW
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BU of 7tmw by Molmil
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Descriptor: Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Erlandson, S.C, Rawson, S, Kruse, A.C.
Deposit date:2022-01-20
Release date:2023-02-15
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The relaxin receptor RXFP1 signals through a mechanism of autoinhibition.
Nat.Chem.Biol., 19, 2023
8OJ5
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BU of 8oj5 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution)
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Penchev, I, DaRosa, P.A, Peter, J.J, Kulathu, Y, Becker, T, Beckmann, R, Kopito, R.
Deposit date:2023-03-23
Release date:2024-02-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OHD
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BU of 8ohd by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native)
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
Deposit date:2023-03-21
Release date:2024-02-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OJ8
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BU of 8oj8 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native)
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
Deposit date:2023-03-24
Release date:2024-02-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OJ0
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BU of 8oj0 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native)
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
Deposit date:2023-03-23
Release date:2024-02-21
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
6ZVI
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BU of 6zvi by Molmil
Mbf1-ribosome complex
Descriptor: 18S rRNA, 40S ribosomal protein S0-A, 40S ribosomal protein S10-A, ...
Authors:Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R.
Deposit date:2020-07-24
Release date:2020-09-09
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
6ZVH
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BU of 6zvh by Molmil
EDF1-ribosome complex
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R.
Deposit date:2020-07-24
Release date:2020-08-19
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
6BOF
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BU of 6bof by Molmil
Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Bera, A.K, Yan, W, Westover, K.D.
Deposit date:2017-11-20
Release date:2019-05-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov, 9, 2019
6MA5
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BU of 6ma5 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 1a
Descriptor: Host Cell Factor 1 peptide, N-[(2R)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}acetyl]-N-[(thiophen-2-yl)methyl]glycine, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Martin, S.E.S, Lazarus, M.B, Walker, S.
Deposit date:2018-08-25
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA1
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BU of 6ma1 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 4a
Descriptor: Host Cell Factor 1 peptide, N-[(2R)-2-{[(7-chloro-2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}-2-(2-methoxyphenyl)acetyl]-N-[(thiophen-2-yl)methyl]glycine, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Martin, S.E.S, Lazarus, M.B, Walker, S.
Deposit date:2018-08-25
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA4
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BU of 6ma4 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 3a
Descriptor: 5-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl)methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}pentanoic acid, Host Cell Factor 1 peptide, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Martin, S.E.S, Lazarus, M.B, Walker, S.
Deposit date:2018-08-25
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6BP4
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BU of 6bp4 by Molmil
Structure of the S. pombe Clr4 catalytic domain bound to SAM
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific, S-ADENOSYLMETHIONINE, ...
Authors:Currie, M.A, Moazed, D.
Deposit date:2017-11-21
Release date:2018-07-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7701 Å)
Cite:Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Nature, 560, 2018
6MA3
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BU of 6ma3 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 2a
Descriptor: 4-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl)methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}butanoic acid, Host Cell Factor 1 peptide, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Martin, S.E.S, Lazarus, M.B, Walker, S.
Deposit date:2018-08-25
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA2
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BU of 6ma2 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor ent-1a
Descriptor: Host Cell Factor 1 peptide, N-[(2S)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}acetyl]-N-[(thiophen-2-yl)methyl]glycine, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Authors:Martin, S.E.S, Lazarus, M.B, Walker, S.
Deposit date:2018-08-25
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6BOX
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BU of 6box by Molmil
Structure of the S. pombe Clr4 catalytic domain bound to SAH
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Currie, M.A, Moazed, D.
Deposit date:2017-11-21
Release date:2018-07-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.412 Å)
Cite:Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Nature, 560, 2018
5V83
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BU of 5v83 by Molmil
Structure of DCN1 bound to NAcM-HIT
Descriptor: Lysozyme,DCN1-like protein 1 chimera, N-(1-benzylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
Deposit date:2017-03-21
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
5V86
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BU of 5v86 by Molmil
Structure of DCN1 bound to NAcM-OPT
Descriptor: Lysozyme,DCN1-like protein 1, N-benzyl-N-(1-butylpiperidin-4-yl)-N'-(3,4-dichlorophenyl)urea
Authors:Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
Deposit date:2017-03-21
Release date:2017-05-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.374 Å)
Cite:Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
5V89
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BU of 5v89 by Molmil
Structure of DCN4 PONY domain bound to CUL1 WHB
Descriptor: Cullin-1, DCN1-like protein 4
Authors:Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
Deposit date:2017-03-21
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
5V88
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BU of 5v88 by Molmil
Structure of DCN1 bound to NAcM-COV
Descriptor: Lysozyme,DCN1-like protein 1, N-{2-[({1-[(2R)-pentan-2-yl]piperidin-4-yl}{[3-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]phenyl}propanamide
Authors:Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T.
Deposit date:2017-03-21
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Nat. Chem. Biol., 13, 2017
7JIF
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BU of 7jif by Molmil
HRAS A59T GppNHp
Descriptor: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
Authors:Johnson, C.W, Haigis, K.M.
Deposit date:2020-07-23
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.757 Å)
Cite:Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
7JII
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BU of 7jii by Molmil
HRAS A59E GDP
Descriptor: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Johnson, C.W, Haigis, K.M.
Deposit date:2020-07-23
Release date:2022-03-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.532 Å)
Cite:Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022

 

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数据于2024-06-19公开中

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