6MA1

Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 4a

Summary for 6MA1

Entry DOI	10.2210/pdb6ma1/pdb
Descriptor	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Host Cell Factor 1 peptide, N-[(2R)-2-{[(7-chloro-2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}-2-(2-methoxyphenyl)acetyl]-N-[(thiophen-2-yl)methyl]glycine, ... (4 entities in total)
Functional Keywords	ogt, o-glcnac, glycosyltransferase, enzyme-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	83159.15
Authors	Martin, S.E.S.,Lazarus, M.B.,Walker, S. (deposition date: 2018-08-25, release date: 2018-10-17, Last modification date: 2023-10-11)
Primary citation	Martin, S.E.S.,Tan, Z.W.,Itkonen, H.M.,Duveau, D.Y.,Paulo, J.A.,Janetzko, J.,Boutz, P.L.,Tork, L.,Moss, F.A.,Thomas, C.J.,Gygi, S.P.,Lazarus, M.B.,Walker, S. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J. Am. Chem. Soc., 140:13542-13545, 2018 Cited by PubMed: 30285435 DOI: 10.1021/jacs.8b07328 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation