6KS6
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![BU of 6ks6 by Molmil](/molmil-images/mine/6ks6) | TRiC at 0.2 mM ADP-AlFx, Conformation 1, 0.2-C1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Jin, M, Cong, Y. | Deposit date: | 2019-08-23 | Release date: | 2019-09-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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4ID7
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![BU of 4id7 by Molmil](/molmil-images/mine/4id7) | ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | Descriptor: | Activated CDC42 kinase 1, SULFATE ION, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | Authors: | Jin, M, Wang, J, Kleinberg, A, Kadalbajoo, M, Siu, K, Cooke, A, Bittner, M, Yao, Y, Thelemann, A, Ji, Q, Bhagwat, S, Crew, A.P, Pachter, J, Epstein, D, Mulvihill, M.J. | Deposit date: | 2012-12-11 | Release date: | 2013-01-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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6KRE
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![BU of 6kre by Molmil](/molmil-images/mine/6kre) | TRiC at 0.05 mM ADP-AlFx, Conformation 2, 0.05-C2 | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Jin, M, Cong, Y. | Deposit date: | 2019-08-21 | Release date: | 2019-09-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.45 Å) | Cite: | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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6KRD
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![BU of 6krd by Molmil](/molmil-images/mine/6krd) | TRiC at 0.05 mM ADP-AlFx, Conformation 4, 0.05-C4 | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Jin, M, Cong, Y. | Deposit date: | 2019-08-21 | Release date: | 2019-09-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.38 Å) | Cite: | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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6KS8
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![BU of 6ks8 by Molmil](/molmil-images/mine/6ks8) | TRiC at 0.1 mM ADP-AlFx, Conformation 4, 0.1-C4 | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Jin, M, Cong, Y. | Deposit date: | 2019-08-23 | Release date: | 2019-09-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.69 Å) | Cite: | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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6KS7
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![BU of 6ks7 by Molmil](/molmil-images/mine/6ks7) | TRiC at 0.1 mM ADP-AlFx, Conformation 1, 0.1-C1 | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Jin, M, Cong, Y. | Deposit date: | 2019-08-23 | Release date: | 2019-09-18 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.62 Å) | Cite: | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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1CHO
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![BU of 1cho by Molmil](/molmil-images/mine/1cho) | CRYSTAL AND MOLECULAR STRUCTURES OF THE COMPLEX OF ALPHA-*CHYMOTRYPSIN WITH ITS INHIBITOR TURKEY OVOMUCOID THIRD DOMAIN AT 1.8 ANGSTROMS RESOLUTION | Descriptor: | ALPHA-CHYMOTRYPSIN A, TURKEY OVOMUCOID THIRD DOMAIN (OMTKY3) | Authors: | Fujinaga, M, Sielecki, A.R, Read, R.J, Ardelt, W, Laskowskijunior, M, James, M.N.G. | Deposit date: | 1988-03-04 | Release date: | 1988-07-16 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution. J.Mol.Biol., 195, 1987
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4CMP
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![BU of 4cmp by Molmil](/molmil-images/mine/4cmp) | Crystal structure of S. pyogenes Cas9 | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION | Authors: | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | Deposit date: | 2014-01-16 | Release date: | 2014-02-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation. Science, 343, 2014
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4CMQ
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![BU of 4cmq by Molmil](/molmil-images/mine/4cmq) | Crystal structure of Mn-bound S.pyogenes Cas9 | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION | Authors: | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | Deposit date: | 2014-01-17 | Release date: | 2014-02-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation Science, 343, 2014
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1QRP
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![BU of 1qrp by Molmil](/molmil-images/mine/1qrp) | Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME | Descriptor: | PEPSIN 3A, methyl N-[(2S)-2-({(S)-hydroxy[(1R)-3-methyl-1-{[N-(3-methylbutanoyl)-L-valyl-L-valyl]amino}butyl]phosphoryl}oxy)-3-phenylpropanoyl]-L-alanyl-L-alaninate | Authors: | Fujinaga, M, Cherney, M.M, Tarasova, N.I, Bartlett, P.A, Hanson, J.E, James, M.N.G. | Deposit date: | 1999-06-15 | Release date: | 1999-06-18 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog. Acta Crystallogr.,Sect.D, 56, 2000
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1SRY
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![BU of 1sry by Molmil](/molmil-images/mine/1sry) | |
1TON
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![BU of 1ton by Molmil](/molmil-images/mine/1ton) | |
1W3B
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![BU of 1w3b by Molmil](/molmil-images/mine/1w3b) | The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha. | Descriptor: | CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 | Authors: | Jinek, M, Rehwinkel, J, Lazarus, B.D, Izaurralde, E, Hanover, J.A, Conti, E. | Deposit date: | 2004-07-14 | Release date: | 2004-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha Nat.Struct.Mol.Biol., 11, 2004
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2VXG
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![BU of 2vxg by Molmil](/molmil-images/mine/2vxg) | Crystal structure of the conserved C-terminal region of Ge-1 | Descriptor: | CG6181-PA, ISOFORM A | Authors: | Jinek, M, Eulalio, A, Lingel, A, Helms, S, Conti, E, Izaurralde, E. | Deposit date: | 2008-07-04 | Release date: | 2008-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The C-Terminal Region of Ge-1 Presents Conserved Structural Features Required for P-Body Localization. RNA, 14, 2008
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1FUJ
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![BU of 1fuj by Molmil](/molmil-images/mine/1fuj) | PR3 (MYELOBLASTIN) | Descriptor: | PR3, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Fujinaga, M, Chernaia, M.M, Halenbeck, R, Koths, K, James, M.N.G. | Deposit date: | 1996-01-25 | Release date: | 1996-07-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. J.Mol.Biol., 261, 1996
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1S2B
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![BU of 1s2b by Molmil](/molmil-images/mine/1s2b) | Structure of SCP-B the first member of the Eqolisin family of Peptidases to have its structure determined | Descriptor: | Scytalidopepsin B | Authors: | Fujinaga, M, Cherney, M.M, Oyama, H, Oda, K, James, M.N. | Deposit date: | 2004-01-08 | Release date: | 2004-04-27 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum Proc.Natl.Acad.Sci.USA, 101, 2004
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1S2K
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![BU of 1s2k by Molmil](/molmil-images/mine/1s2k) | Structure of SCP-B a member of the Eqolisin family of Peptidases in a complex with a Tripeptide Ala-Ile-His | Descriptor: | Ala-Ile-His tripeptide, Scytalidopepsin B, TYROSINE | Authors: | Fujinaga, M, Cherney, M.M, Oyama, H, Oda, K, James, M.N. | Deposit date: | 2004-01-08 | Release date: | 2004-04-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum Proc.Natl.Acad.Sci.USA, 101, 2004
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1PSN
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![BU of 1psn by Molmil](/molmil-images/mine/1psn) | THE CRYSTAL STRUCTURE OF HUMAN PEPSIN AND ITS COMPLEX WITH PEPSTATIN | Descriptor: | PEPSIN 3A | Authors: | Fujinaga, M, Chernaia, M.M, Tarasova, N, Mosimann, S.C, James, M.N.G. | Deposit date: | 1995-01-23 | Release date: | 1995-04-20 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of human pepsin and its complex with pepstatin. Protein Sci., 4, 1995
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1PSO
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![BU of 1pso by Molmil](/molmil-images/mine/1pso) | The crystal structure of human pepsin and its complex with pepstatin | Descriptor: | PEPSIN 3A, PEPSTATIN | Authors: | Fujinaga, M, Chernaia, M.M, Tarasova, N, Mosimann, S.C, James, M.N.G. | Deposit date: | 1995-01-23 | Release date: | 1995-04-20 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human pepsin and its complex with pepstatin. Protein Sci., 4, 1995
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2X04
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![BU of 2x04 by Molmil](/molmil-images/mine/2x04) | Crystal structure of the PABC-TNRC6C complex | Descriptor: | POLYADENYLATE-BINDING PROTEIN 1, SULFATE ION, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN | Authors: | Jinek, M, Fabian, M.R, Coyle, S.M, Sonenberg, N, Doudna, J.A. | Deposit date: | 2009-12-04 | Release date: | 2010-01-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation Nat.Struct.Mol.Biol., 17, 2010
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2Y35
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![BU of 2y35 by Molmil](/molmil-images/mine/2y35) | Crystal structure of Xrn1-substrate complex | Descriptor: | DT11 (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', LD22664P, MAGNESIUM ION | Authors: | Jinek, M, Coyle, S.M, Doudna, J.A. | Deposit date: | 2010-12-18 | Release date: | 2011-03-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay. Mol.Cell, 41, 2011
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2J0B
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![BU of 2j0b by Molmil](/molmil-images/mine/2j0b) | Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese | Descriptor: | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, MANGANESE (II) ION, POTASSIUM ION, ... | Authors: | Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E. | Deposit date: | 2006-08-01 | Release date: | 2006-09-04 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe Nat.Struct.Mol.Biol., 13, 2006
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2J0A
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![BU of 2j0a by Molmil](/molmil-images/mine/2j0a) | Structure of the catalytic domain of mouse Manic Fringe | Descriptor: | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, POTASSIUM ION, SULFATE ION | Authors: | Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E. | Deposit date: | 2006-08-01 | Release date: | 2006-09-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe Nat.Struct.Mol.Biol., 13, 2006
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2ALP
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![BU of 2alp by Molmil](/molmil-images/mine/2alp) | REFINED STRUCTURE OF ALPHA-LYTIC PROTEASE AT 1.7 ANGSTROMS RESOLUTION. ANALYSIS OF HYDROGEN BONDING AND SOLVENT STRUCTURE | Descriptor: | ALPHA-LYTIC PROTEASE, SULFATE ION | Authors: | Fujinaga, M, Delbaere, L.T.J, Brayer, G.D, James, M.N.G. | Deposit date: | 1985-03-07 | Release date: | 1985-07-17 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure. J.Mol.Biol., 184, 1985
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6F9S
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![BU of 6f9s by Molmil](/molmil-images/mine/6f9s) | |