4ID7

ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol

Summary for 4ID7

Entry DOI	10.2210/pdb4id7/pdb
Descriptor	Activated CDC42 kinase 1, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: Q07912
Total number of polymer chains	1
Total formula weight	31693.57
Authors	Jin, M.,Wang, J.,Kleinberg, A.,Kadalbajoo, M.,Siu, K.,Cooke, A.,Bittner, M.,Yao, Y.,Thelemann, A.,Ji, Q.,Bhagwat, S.,Crew, A.P.,Pachter, J.,Epstein, D.,Mulvihill, M.J. (deposition date: 2012-12-11, release date: 2013-01-30, Last modification date: 2024-02-28)
Primary citation	Jin, M.,Wang, J.,Kleinberg, A.,Kadalbajoo, M.,Siu, K.W.,Cooke, A.,Bittner, M.A.,Yao, Y.,Thelemann, A.,Ji, Q.,Bhagwat, S.,Mulvihill, K.M.,Rechka, J.A.,Pachter, J.A.,Crew, A.P.,Epstein, D.,Mulvihill, M.J. Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Bioorg.Med.Chem.Lett., 23:979-984, 2013 Cited by PubMed: 23317569 DOI: 10.1016/j.bmcl.2012.12.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation