1QRP
Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME
Summary for 1QRP
Entry DOI | 10.2210/pdb1qrp/pdb |
Related PRD ID | PRD_000657 |
Descriptor | PEPSIN 3A, methyl N-[(2S)-2-({(S)-hydroxy[(1R)-3-methyl-1-{[N-(3-methylbutanoyl)-L-valyl-L-valyl]amino}butyl]phosphoryl}oxy)-3-phenylpropanoyl]-L-alanyl-L-alaninate (3 entities in total) |
Functional Keywords | aspartic proteinase, phosphonate inhibitor, transition state analogue, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35385.75 |
Authors | Fujinaga, M.,Cherney, M.M.,Tarasova, N.I.,Bartlett, P.A.,Hanson, J.E.,James, M.N.G. (deposition date: 1999-06-15, release date: 1999-06-18, Last modification date: 2012-12-12) |
Primary citation | Fujinaga, M.,Cherney, M.M.,Tarasova, N.I.,Bartlett, P.A.,Hanson, J.E.,James, M.N. Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog. Acta Crystallogr.,Sect.D, 56:272-279, 2000 Cited by PubMed: 10713513DOI: 10.1107/S0907444999016376 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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