1QRP

Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HH0 E 327

Chain	Residue
E	MET12
E	PHE111
E	TYR189
E	ILE213
E	ASP215
E	GLY217
E	THR218
E	SER219
E	HOH461
E	GLU13
E	ASP32
E	GLY34
E	SER35
E	THR74
E	TYR75
E	GLY76
E	THR77

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNLWV

Chain	Residue	Details
E	VAL29-VAL40
E	ALA212-GLY223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:7663352

Chain	Residue	Details
E	ASP32
E	ASP215

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03954

Chain	Residue	Details
E	SER68

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