2F69
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![BU of 2f69 by Molmil](/molmil-images/mine/2f69) | Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Couture, J.-F, Collazo, E, Hauk, G, Trievel, R.C. | Deposit date: | 2005-11-28 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis for the methylation site specificity of SET7/9 Nat.Struct.Mol.Biol., 13, 2006
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1XJB
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![BU of 1xjb by Molmil](/molmil-images/mine/1xjb) | Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C2, ... | Authors: | Couture, J.-F, Pereira de Jesus-Tran, K, Roy, A.-M, Legrand, P, Cantin, L, Cote, P.-L, Luu-The, V, Labrie, F, Breton, R. | Deposit date: | 2004-09-23 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen Protein Sci., 14, 2005
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1ZKK
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![BU of 1zkk by Molmil](/molmil-images/mine/1zkk) | Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase, H4 lysine-20 specific, Peptide corresponding to residues 15-24 of histone H4, ... | Authors: | Couture, J.-F, Collazo, E, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2005-05-03 | Release date: | 2005-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase Genes Dev., 19, 2005
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3P4F
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![BU of 3p4f by Molmil](/molmil-images/mine/3p4f) | Structural and biochemical insights into MLL1 core complex assembly and regulation. | Descriptor: | Histone-lysine N-methyltransferase MLL, Retinoblastoma-binding protein 5, WD repeat-containing protein 5 | Authors: | Avdic, V, Zhang, P, Lanouette, S, Groulx, A, Tremblay, V, Brunzelle, J.B, Couture, J.-F. | Deposit date: | 2010-10-06 | Release date: | 2010-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural and biochemical insights into MLL1 core complex assembly. Structure, 19, 2011
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5EJ3
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![BU of 5ej3 by Molmil](/molmil-images/mine/5ej3) | Crystal structure of XlnB2 | Descriptor: | Endo-1,4-beta-xylanase B | Authors: | Couture, J.-F. | Deposit date: | 2015-11-01 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.314 Å) | Cite: | Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans. Biochemistry, 55, 2016
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6MV7
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![BU of 6mv7 by Molmil](/molmil-images/mine/6mv7) | Crystal structure of RNAse 6 | Descriptor: | ADENOSINE MONOPHOSPHATE, Ribonuclease K6 | Authors: | Couture, J.-F, Doucet, N. | Deposit date: | 2018-10-24 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding. Biochemistry, 59, 2020
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6MV6
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![BU of 6mv6 by Molmil](/molmil-images/mine/6mv6) | Crystal structure of RNAse 6 | Descriptor: | PHOSPHATE ION, Ribonuclease K6 | Authors: | Couture, J.-F, Doucet, N. | Deposit date: | 2018-10-24 | Release date: | 2019-11-13 | Last modified: | 2020-05-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding. Biochemistry, 59, 2020
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1Q13
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![BU of 1q13 by Molmil](/molmil-images/mine/1q13) | Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION, ... | Authors: | Couture, J.-F, Cantin, L, Legrand, P, Luu-The, V, Labrie, F, Breton, R. | Deposit date: | 2003-07-18 | Release date: | 2004-11-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. J. Mol. Biol., 339, 2004
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3F9Y
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![BU of 3f9y by Molmil](/molmil-images/mine/3f9y) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F9W
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![BU of 3f9w by Molmil](/molmil-images/mine/3f9w) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F9Z
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![BU of 3f9z by Molmil](/molmil-images/mine/3f9z) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F9X
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![BU of 3f9x by Molmil](/molmil-images/mine/3f9x) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me2 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2Q8C
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![BU of 2q8c by Molmil](/molmil-images/mine/2q8c) | Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, HISTONE 3 PEPTIDE, JmjC domain-containing histone demethylation protein 3A, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.047 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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2Q8D
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![BU of 2q8d by Molmil](/molmil-images/mine/2q8d) | Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate | Descriptor: | HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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2Q8E
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![BU of 2q8e by Molmil](/molmil-images/mine/2q8e) | Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase | Descriptor: | JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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5VBC
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![BU of 5vbc by Molmil](/molmil-images/mine/5vbc) | Crystal structure of ATXR5 in complex with histone H3.1 | Descriptor: | DIMETHYL SULFOXIDE, Histone H3.1 peptide, Probable Histone-lysine N-methyltransferase ATXR5, ... | Authors: | Couture, J.-F, Bergamin, E. | Deposit date: | 2017-03-29 | Release date: | 2017-04-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular basis for the methylation specificity of ATXR5 for histone H3. Nucleic Acids Res., 45, 2017
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4RIQ
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![BU of 4riq by Molmil](/molmil-images/mine/4riq) | |
4ETS
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![BU of 4ets by Molmil](/molmil-images/mine/4ets) | |
3IVS
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![BU of 3ivs by Molmil](/molmil-images/mine/3ivs) | Homocitrate Synthase Lys4 | Descriptor: | COBALT (II) ION, Homocitrate synthase, mitochondrial, ... | Authors: | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | Deposit date: | 2009-09-01 | Release date: | 2009-09-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J.Biol.Chem., 284, 2009
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3IVU
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![BU of 3ivu by Molmil](/molmil-images/mine/3ivu) | Homocitrate Synthase Lys4 bound to 2-OG | Descriptor: | 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ... | Authors: | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | Deposit date: | 2009-09-01 | Release date: | 2009-09-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J.Biol.Chem., 284, 2009
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3IVT
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![BU of 3ivt by Molmil](/molmil-images/mine/3ivt) | Homocitrate Synthase Lys4 bound to 2-OG | Descriptor: | 2-OXOGLUTARIC ACID, Homocitrate synthase, mitochondrial, ... | Authors: | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | Deposit date: | 2009-09-01 | Release date: | 2009-09-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J.Biol.Chem., 284, 2009
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5H89
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![BU of 5h89 by Molmil](/molmil-images/mine/5h89) | Crystal structure of mRojoA mutant - T16V - P63Y - W143G - L163V | Descriptor: | mRojoA fluorescent protein | Authors: | Pandelieva, A.T, Tremblay, V, Sarvan, S, Chica, R.A, Couture, J.-F. | Deposit date: | 2015-12-23 | Release date: | 2016-01-27 | Last modified: | 2016-03-02 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif. Acs Chem.Biol., 11, 2016
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5H88
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![BU of 5h88 by Molmil](/molmil-images/mine/5h88) | Crystal structure of mRojoA mutant - T16V -P63F - W143A - L163V | Descriptor: | mRojoA fluorescent protein | Authors: | Pandelieva, A.T, Tremblay, V, Sarvan, S, Chica, R.A, Couture, J.-F. | Deposit date: | 2015-12-23 | Release date: | 2016-01-27 | Last modified: | 2016-03-02 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif. Acs Chem.Biol., 11, 2016
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5H87
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![BU of 5h87 by Molmil](/molmil-images/mine/5h87) | Crystal structure of mRojoA mutant - P63H - W143S | Descriptor: | mRojoA fluorescent protein | Authors: | Pandelieva, A.T, Tremblay, V, Sarvan, S, Chica, R.A, Couture, J.-F. | Deposit date: | 2015-12-23 | Release date: | 2016-01-27 | Last modified: | 2016-03-02 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif. Acs Chem.Biol., 11, 2016
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3M53
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![BU of 3m53 by Molmil](/molmil-images/mine/3m53) | SET7/9 in complex with TAF10 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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