1XJB

Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules

Summary for 1XJB

Entry DOI	10.2210/pdb1xjb/pdb
Descriptor	Aldo-keto reductase family 1 member C2, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (8 entities in total)
Functional Keywords	human 3alphahds3; aldo-keto reductase; nadp; induce-fit mecanism, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	76163.19
Authors	Couture, J.-F.,Pereira de Jesus-Tran, K.,Roy, A.-M.,Legrand, P.,Cantin, L.,Cote, P.-L.,Luu-The, V.,Labrie, F.,Breton, R. (deposition date: 2004-09-23, release date: 2005-06-21, Last modification date: 2023-08-23)
Primary citation	Couture, J.-F.,Roy, A.-M.,Cantin, L.,Legrand, P.,Luu-The, V.,Labrie, F.,Breton, R. Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen Protein Sci., 14:1485-1497, 2005 Cited by PubMed: 15929998 DOI: 10.1110/ps.051353205 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation