1XJB
Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aldo-keto reductase family 1 member C2 | polymer | 325 | 36956.4 | 2 | UniProt (P52895) Pfam (PF00248) | Homo sapiens (human) | h3alphaHSD3; Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Dihydrodiol dehydrogenase 2; DD2 |
| 2 | C, D, I (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 3 | E, L (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 4 | F, M (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | G (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 6 | H (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 7 | J, K (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | N, O (A, B) | water | water | 18.0 | 477 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 323 (UniProt: P52895)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | cloning artifact |
| Val 0 | - | cloning artifact |
| Asp 1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73912.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2250.5 | |
| All* | Total formula weight | 76163.2 |
