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Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalylglycine (NOG)
Descriptor:	1,2-ETHANEDIOL, GH14974p, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXH

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and succinate
Descriptor:	1,2-ETHANEDIOL, GH14974p, MAGNESIUM ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXJ

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and 2,4-PDCA
Descriptor:	1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GH14974p, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXL

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalyl-D-phenylalanine (NOFD)
Descriptor:	1,2-ETHANEDIOL, ACETATE ION, GH14974p, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXG

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and 2OG
Descriptor:	1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, GH14974p, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.641 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

7YXK

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and N-oxalyl-D-alanine (NODA)
Descriptor:	(2~{R})-2-(carboxycarbonylamino)propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-02-16
Release date:	2022-04-27
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.43 Å)
Cite:	Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022

2Y34

S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN9
Descriptor:	EGL NINE HOMOLOG 1, FE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Authors:	Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:	2010-12-18
Release date:	2010-12-29
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). J. Mol. Biol., 410, 2011

2Y33

S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN9
Descriptor:	EGL NINE HOMOLOG 1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ZINC ION
Authors:	Chowdhury, R, Clifton, I.J, Schofield, C.J.
Deposit date:	2010-12-18
Release date:	2010-12-29
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (Egln1) J.Mol.Biol., 410, 2011

6YVW

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with monocyclic BB-328
Descriptor:	4-[(5-bromanyl-4,6-dimethyl-pyridin-2-yl)amino]-4-oxidanylidene-butanoic acid, Egl nine homolog 1, FE (III) ION, ...
Authors:	Chowdhury, R, Banerji, B, Schofield, C.J.
Deposit date:	2020-04-28
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.97 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW1

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:	2-OXOGLUTARIC ACID, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.46 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW2

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW3

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, GLYCEROL, Hypoxia-inducible factor 1-alpha, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.279 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YVZ

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic JLS-367
Descriptor:	4-[(5-bromanylisoquinolin-3-yl)amino]-4-oxidanylidene-butanoic acid, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Sorensen, J.L, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW0

Lysine-N,N-Dimethylated HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with BB-287
Descriptor:	4-(isoquinolin-3-ylamino)-4-oxobutanoic acid, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YVX

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic BB-287
Descriptor:	4-(isoquinolin-3-ylamino)-4-oxobutanoic acid, BICARBONATE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Banerji, B, Schofield, C.J.
Deposit date:	2020-04-28
Release date:	2020-12-30
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

6YW4

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer)
Descriptor:	Egl nine homolog 1, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2020-04-29
Release date:	2020-12-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.528 Å)
Cite:	Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10, 2020

3HQU

PHD2:Fe:UN9:partial HIF1-alpha substrate complex
Descriptor:	Egl nine homolog 1, FE (II) ION, Hypoxia-inducible factor 1 alpha, ...
Authors:	Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:	2009-06-08
Release date:	2009-07-28
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009

3HQR

PHD2:Mn:NOG:HIF1-alpha substrate complex
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, McDonough, M.A, Schofield, C.J.
Deposit date:	2009-06-08
Release date:	2009-07-28
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009

7ZCC

yxBC from Bacillus subtilis in complex with Mn and N-oxalylglycine (NOG)
Descriptor:	GLYCEROL, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2022-03-27
Release date:	2023-04-05
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.848 Å)
Cite:	yxBC from Bacillus subtilis in complex with Mn and N-oxalylglycine (NOG) To Be Published

5LAS

HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3)
Descriptor:	Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-14
Release date:	2016-08-31
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBC

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, CHLORIDE ION, Egl nine homolog 1, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.816 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LB6

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	Egl nine homolog 1, GLYCEROL, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBE

HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.749 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5LBB

HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Descriptor:	BICARBONATE ION, Egl nine homolog 1, MANGANESE (II) ION, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-15
Release date:	2016-08-31
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

5L9B

HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
Descriptor:	2-OXOGLUTARIC ACID, Egl nine homolog 1, Hypoxia-inducible factor 1-alpha, ...
Authors:	Chowdhury, R, Schofield, C.J.
Deposit date:	2016-06-10
Release date:	2016-08-31
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun, 7, 2016

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