2LAY
 
 | | Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide | | Descriptor: | Mothers against decapentaplegic homolog 1, Yorkie homolog | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LB2
 | | Structure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3 | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3 | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LB1
 | | Structure of the second domain of human Smurf1 in complex with a human Smad1 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1 | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LAJ
 | | Third WW domain of human Nedd4L in complex with doubly phosphorylated human smad3 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Mothers against decapentaplegic homolog 3 | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-16 | | Release date: | 2011-07-06 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LTX
 | | Smurf1 WW2 domain in complex with a Smad7 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase SMURF1, Smad7 derived peptide | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J. | | Deposit date: | 2012-06-04 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
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2LTY
 | | NEDD4L WW2 domain in complex with a Smad7 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, Smad7 derived peptide | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J. | | Deposit date: | 2012-06-04 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
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2LTZ
 | | Smurf2 WW3 domain in complex with a Smad7 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase SMURF2, Smad7 derived peptide | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J. | | Deposit date: | 2012-06-04 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
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2LAZ
 | | Structure of the first WW domain of human Smurf1 in complex with a mono-phosphorylated human Smad1 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1 | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LAW
 | | Structure of the second WW domain from human YAP in complex with a human Smad1 derived peptide | | Descriptor: | Mothers against decapentaplegic homolog 1, Yorkie homolog | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LTW
 | | YAP WW1 in complex with a Smad7 derived peptide | | Descriptor: | Smad7 derived peptide, Yorkie homolog | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J. | | Deposit date: | 2012-06-04 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
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2LB0
 | | Structure of the first WW domain of human Smurf1 in complex with a di-phosphorylated human Smad1 derived peptide | | Descriptor: | E3 ubiquitin-protein ligase SMURF1, Mothers against decapentaplegic homolog 1 | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LAX
 | | Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide. | | Descriptor: | Mothers against decapentaplegic homolog 1, Yorkie homolog | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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2LTV
 | | YAP WW2 in complex with a Smad7 derived peptide | | Descriptor: | Smad7 derived peptide, Yorkie homolog | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Xi, Q, Lopes, T, Gao, S, Massague, J. | | Deposit date: | 2012-06-04 | | Release date: | 2012-11-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways.
Structure, 20, 2012
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2LB3
 | | Structure of the WW domain of PIN1 in complex with a human phosphorylated Smad3 derived peptide | | Descriptor: | Mothers against decapentaplegic homolog 2, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | Authors: | Macias, M.J, Aragon, E, Goerner, N, Zaromytidou, A, Xi, Q, Escobedo, A, Massague, J. | | Deposit date: | 2011-03-22 | | Release date: | 2011-07-06 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
Genes Dev., 25, 2011
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4R9P
 | | An Expansion to the Smad MH2-family: The structure of the N-MH2 expanded domain | | Descriptor: | RE28239p | | Authors: | Beich-Frandsen, M, Aragon, E, Llimargas, M, Benach, J, Riera, A, Macias, M.J. | | Deposit date: | 2014-09-06 | | Release date: | 2015-04-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.592 Å) | | Cite: | Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2
Acta Crystallogr.,Sect.D, 71, 2015
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6Z7O
 | | Crystal structure of Thioredoxin T from Drosophila melanogaster | | Descriptor: | Thioredoxin-T, ZINC ION | | Authors: | Freier, R, Aragon, E, Baginski, B, Pluta, R, Martin-Malpartida, P, Torner, C, Gonzaez, C, Macias, M. | | Deposit date: | 2020-05-31 | | Release date: | 2020-10-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins.
Iucrj, 8, 2021
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2MPT
 | | WW3 domain of Nedd4L in complex with its HECT domain PY motif | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like | | Authors: | Escobedo, A, Macias, M.J, Gomes, T, Aragon, E, Martin-Malpartida, P, Ruiz, L. | | Deposit date: | 2014-06-02 | | Release date: | 2014-10-22 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L.
Structure, 22, 2014
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6H3R
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6ZMU
 | | Crystal structure of the germline-specific thioredoxin protein Deadhead (Thioredoxin-1) from Drospohila melanogaster, P43212 | | Descriptor: | SODIUM ION, SULFATE ION, Thioredoxin-1 | | Authors: | Baginski, B, Pluta, R, Macias, M.J. | | Deposit date: | 2020-07-03 | | Release date: | 2020-10-21 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins.
Iucrj, 8, 2021
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6Y1Q
 | | Cortistatin analog with improved immunoregulatory activity | | Descriptor: | Analog 5, OCTANOIC ACID (CAPRYLIC ACID) | | Authors: | Rol, A. | | Deposit date: | 2020-02-13 | | Release date: | 2021-01-27 | | Last modified: | 2024-07-10 | | Method: | SOLUTION NMR | | Cite: | Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease.
Nat Commun, 12, 2021
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6FQQ
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6FQP
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6TBZ
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6TCE
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5OD6
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