6Y1Q

Cortistatin analog with improved immunoregulatory activity

Summary for 6Y1Q

• Entry DOI: 10.2210/pdb6y1q/pdb
• NMR Information: BMRB: 34491
• Descriptor: Analog 5, OCTANOIC ACID (CAPRYLIC ACID) (2 entities in total)
• Functional Keywords: peptidomimetic, analogue, medical chemistry, hormone
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 1910.37

Authors

Rol, A. (deposition date: 2020-02-13, release date: 2021-01-27, Last modification date: 2023-11-15)

• Primary citation: Rol, A.,Todorovski, T.,Martin-Malpartida, P.,Escola, A.,Gonzalez-Rey, E.,Aragon, E.,Verdaguer, X.,Valles-Miret, M.,Farrera-Sinfreu, J.,Puig, E.,Fernandez-Carneado, J.,Ponsati, B.,Delgado, M.,Riera, A.,Macias, M.J.; Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease.; Nat Commun, 12:1869-1869, 2021; PubMed: 33767180; DOI: 10.1038/s41467-021-22076-5

Experimental method

SOLUTION NMR