1ILE
| ISOLEUCYL-TRNA SYNTHETASE | Descriptor: | ISOLEUCYL-TRNA SYNTHETASE, ZINC ION | Authors: | Nureki, O, Vassylyev, D.G, Tateno, M, Shimada, A, Nakama, T, Fukai, S, Konno, M, Schimmel, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 1998-02-24 | Release date: | 1999-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Enzyme structure with two catalytic sites for double-sieve selection of substrate. Science, 280, 1998
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3HTZ
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8FFY
| Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL) | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ... | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | Deposit date: | 2022-12-11 | Release date: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition. Nat Commun, 14, 2023
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7TZB
| Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial | Authors: | Kuhle, B, Hirschi, M, Doerfel, L, Lander, G, Schimmel, P. | Deposit date: | 2022-02-15 | Release date: | 2022-09-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
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6NOW
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6NLQ
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6NLY
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4Q93
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4QBT
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1PYB
| Crystal Structure of Aquifex aeolicus Trbp111: a Structure-Specific tRNA Binding Protein | Descriptor: | tRNA-binding protein Trbp111 | Authors: | Swairjo, M.A, Morales, A.J, Wang, C.C, Ortiz, A.R, Schimmel, P. | Deposit date: | 2003-07-08 | Release date: | 2003-08-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of trbp111: a structure-specific tRNA-binding protein. Embo J., 19, 2000
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7U2B
| Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL) | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ... | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | Deposit date: | 2022-02-23 | Release date: | 2022-09-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
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7U2A
| Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU) | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ... | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | Deposit date: | 2022-02-23 | Release date: | 2022-09-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
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3G98
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4G85
| Crystal structure of human HisRS | Descriptor: | Histidine-tRNA ligase, cytoplasmic | Authors: | Wei, Z, Wu, J, Zhou, J.J, Yang, X.-L, Zhang, M, Schimmel, P. | Deposit date: | 2012-07-21 | Release date: | 2012-09-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing. Structure, 20, 2012
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4HVC
| Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Bifunctional glutamate/proline--tRNA ligase, MAGNESIUM ION, ... | Authors: | Zhou, H, Sun, L, Yang, X.L, Schimmel, P. | Deposit date: | 2012-11-06 | Release date: | 2013-01-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature, 494, 2012
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4G84
| Crystal structure of human HisRS | Descriptor: | CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic, ... | Authors: | Wei, Z, Wu, J, Zhou, J.J, Yang, X.-L, Zhang, M, Schimmel, P. | Deposit date: | 2012-07-21 | Release date: | 2012-09-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing. Structure, 20, 2012
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1N3L
| Crystal structure of a human aminoacyl-tRNA synthetase cytokine | Descriptor: | GLYCEROL, SULFATE ION, tyrosyl-tRNA synthetase | Authors: | Yang, X.-L, Skene, R.J, McRee, D.E, Schimmel, P. | Deposit date: | 2002-10-28 | Release date: | 2002-11-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Crystal structure of a human aminoacyl-tRNA synthetase cytokine Proc.Natl.Acad.Sci.USA, 99, 2002
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2LW7
| NMR solution structure of human HisRS splice variant | Descriptor: | Histidine--tRNA ligase, cytoplasmic | Authors: | Ye, F, Wei, Z, Wu, J, Schimmel, P, Zhang, M. | Deposit date: | 2012-07-24 | Release date: | 2013-09-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR solution structure of human HisRS splice variant To be Published
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2AZX
| Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase | Descriptor: | 72-MER, GLYCEROL, MAGNESIUM ION, ... | Authors: | Yang, X.L, Otero, F.J, Ewalt, K.L, Liu, J, Swairjo, M.A, Kohrer, C, RajBhandary, U.L, Skene, R.J, McRee, D.E, Schimmel, P. | Deposit date: | 2005-09-12 | Release date: | 2006-08-01 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis. Embo J., 25, 2006
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5T5S
| A fragment of a human tRNA synthetase | Descriptor: | Alanine--tRNA ligase, cytoplasmic | Authors: | Sun, L, Schimmel, P. | Deposit date: | 2016-08-31 | Release date: | 2016-11-30 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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3BJU
| Crystal Structure of tetrameric form of human lysyl-tRNA synthetase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ... | Authors: | Guo, M, Yang, X.L, Schimmel, P. | Deposit date: | 2007-12-04 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa, 105, 2008
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5V58
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5T76
| A fragment of a human tRNA synthetase | Descriptor: | Alanine--tRNA ligase, cytoplasmic | Authors: | Sun, L, Schimmel, P. | Deposit date: | 2016-09-02 | Release date: | 2016-11-30 | Last modified: | 2017-01-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5V59
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3HXZ
| Crystal Structure of catalytic fragment of E. coli AlaRS G237A in complex with AlaSA | Descriptor: | '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 2-HYDROXYETHYL DISULFIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Guo, M, Yang, X.-L, Schimmel, P. | Deposit date: | 2009-06-22 | Release date: | 2009-12-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature, 462, 2009
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