2H4E
| Crystal structure of Cys10 sulfonated transthyretin | Descriptor: | SULFATE ION, Transthyretin | Authors: | Gales, L, Damas, A.M. | Deposit date: | 2006-05-24 | Release date: | 2007-01-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural basis for the protective role of sulfite against transthyretin amyloid formation. Biochim.Biophys.Acta, 1774, 2007
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1Y1D
| Crystal structure of transthyretin in complex with iododiflunisal | Descriptor: | 2',4'-DIFLUORO-4-HYDROXY-5-IODO-1,1'-BIPHENYL-3-CARBOXYLIC ACID, Transthyretin | Authors: | Gales, L, Macedo-Ribeiro, S, Arsequell, G, Valencia, G, Saraiva, M.J, Damas, A.M. | Deposit date: | 2004-11-18 | Release date: | 2005-07-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor. Biochem.J., 388, 2005
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3B56
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3FCB
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3FC8
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4UB9
| Structural and catalytic characterization of molinate hydrolase | Descriptor: | Molinate hydrolase, ZINC ION | Authors: | Leite, J.P, Duarte, M, Paiva, A, Ferreira-da-Silva, F, Matias, P.M, Nunes, O, Gales, L. | Deposit date: | 2014-08-12 | Release date: | 2015-06-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides. Plos One, 10, 2015
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7ACU
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3SSG
| Structure of transthyretin L55P in complex with Zn | Descriptor: | CACODYLATE ION, Transthyretin, ZINC ION | Authors: | Castro-Rodrigues, A.F, Gales, L, Damas, A.M. | Deposit date: | 2011-07-08 | Release date: | 2011-11-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils. Acta Crystallogr.,Sect.D, 67, 2011
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2I5P
| Crystal structure of glyceraldehyde-3-phosphate dehydrogenase isoform 1 from K. marxianus | Descriptor: | BETA-MERCAPTOETHANOL, Glyceraldehyde-3-phosphate dehydrogenase 1, alpha-D-glucopyranose | Authors: | Ferreira-da-Silva, F, Pereira, P.J.B, Gales, L, Moradas-Ferreira, P, Damas, A.M. | Deposit date: | 2006-08-25 | Release date: | 2006-09-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Crystal and Solution Structures of Glyceraldehyde-3-phosphate Dehydrogenase Reveal Different Quaternary Structures. J.Biol.Chem., 281, 2006
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7QH3
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7QH5
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5O7B
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5ONP
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5ONQ
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5ONR
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6EP1
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6EOY
| Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline | Descriptor: | 4-(1,3-benzothiazol-2-yl)-2-methyl-aniline, Transthyretin | Authors: | Leite, J.P, Gales, L. | Deposit date: | 2017-10-10 | Release date: | 2021-10-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease. Eur.J.Med.Chem., 226, 2021
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6GHX
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