6EOY

Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline

Summary for 6EOY

• Entry DOI: 10.2210/pdb6eoy/pdb
• Descriptor: Transthyretin, 4-(1,3-benzothiazol-2-yl)-2-methyl-aniline (3 entities in total)
• Functional Keywords: transthyretin, amyloid, ttr amyloid inhibitor, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 25692.85

Authors

Leite, J.P.,Gales, L. (deposition date: 2017-10-10, release date: 2021-10-06, Last modification date: 2024-01-17)

• Primary citation: Cotrina, E.Y.,Santos, L.M.,Rivas, J.,Blasi, D.,Leite, J.P.,Liz, M.A.,Busquets, M.A.,Planas, A.,Prohens, R.,Gimeno, A.,Jimenez-Barbero, J.,Gales, L.,Llop, J.,Quintana, J.,Cardoso, I.,Arsequell, G.; Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.; Eur.J.Med.Chem., 226:113847-113847, 2021; PubMed: 34555615; DOI: 10.1016/j.ejmech.2021.113847

Experimental method

X-RAY DIFFRACTION (1.38 Å)