7ACU

Crystal structure of human transthyretin in complex with Benzbromarone

Summary for 7ACU

Entry DOI	10.2210/pdb7acu/pdb
Descriptor	Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone (3 entities in total)
Functional Keywords	transthyretin, ttr, benzbromarone, complex, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	26060.37
Authors	Leite, J.P.,Gales, L. (deposition date: 2020-09-11, release date: 2020-10-28, Last modification date: 2024-01-31)
Primary citation	Cotrina, E.Y.,Oliveira, A.,Leite, J.P.,Llop, J.,Gales, L.,Quintana, J.,Cardoso, I.,Arsequell, G. Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 32998442 DOI: 10.3390/ijms21197166 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.541 Å)

Structure validation