3B56

Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid

Summary for 3B56

Entry DOI	10.2210/pdb3b56/pdb
Descriptor	Transthyretin, 2-HYDROXY-3,5-DIIODO-BENZOIC ACID (3 entities in total)
Functional Keywords	transthyretin, amyloid inhibitors, iodine, disease mutation, glycoprotein, hormone, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28334.55
Authors	Gales, L.,Damas, A.M. (deposition date: 2007-10-25, release date: 2008-01-15, Last modification date: 2023-11-01)
Primary citation	Gales, L.,Almeida, M.R.,Arsequell, G.,Valencia, G.,Saraiva, M.J.,Damas, A.M. Iodination of salicylic acid improves its binding to transthyretin Biochim.Biophys.Acta, 1784:512-517, 2008 Cited by PubMed: 18155178 DOI: 10.1016/j.bbapap.2007.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation