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5BQX
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BU of 5bqx by Molmil
Crystal structure of human STING in complex with 3'2'-cGAMP
Descriptor: 3'2'-cGAMP, Stimulator of interferon genes protein
Authors:Wu, J, Zhang, X, Chen, Z.J, Chen, C.
Deposit date:2015-05-29
Release date:2015-06-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Proc.Natl.Acad.Sci.USA, 112, 2015
6BU3
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BU of 6bu3 by Molmil
CTX-M-27 Beta-Lactamase in Complex with a Non-Covalent Tetrazole Inhibitor
Descriptor: Beta-lactamase, N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-benzimidazole-4-carboxamide, SULFATE ION
Authors:Pemberton, O.A, Chen, Y.
Deposit date:2017-12-08
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta-Lactamases.
Antimicrob. Agents Chemother., 62, 2018
6BT6
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BU of 6bt6 by Molmil
CTX-M-14 S237A Beta-Lactamase in Complex with a Non-Covalent Tetrazole Inhibitor
Descriptor: Beta-lactamase, N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-benzimidazole-4-carboxamide
Authors:Pemberton, O.A, Chen, Y.
Deposit date:2017-12-05
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta-Lactamases.
Antimicrob. Agents Chemother., 62, 2018
7BWR
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BU of 7bwr by Molmil
Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric "active state"
Descriptor: CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbB, Meromycolate extension acyl carrier protein, ...
Authors:Gao, R.G, Zhang, L, Wang, Q, Rao, Z.H.
Deposit date:2020-04-15
Release date:2020-05-27
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.
Protein Cell, 11, 2020
5H06
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BU of 5h06 by Molmil
Crystal structure of AmyP in complex with maltose
Descriptor: AmyP, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:He, C, Liu, Y.
Deposit date:2016-10-03
Release date:2017-08-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13
Sci Rep, 7, 2017
2H2H
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BU of 2h2h by Molmil
The Structural basis of sirtuin substrate specificity
Descriptor: Histone H4, NAD-dependent deacetylase, ZINC ION
Authors:Cosgrove, M.S, Wolberger, C.
Deposit date:2006-05-18
Release date:2006-12-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
5H05
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BU of 5h05 by Molmil
Crystal structure of AmyP E221Q in complex with MALTOTRIOSE
Descriptor: AmyP, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:He, C, Liu, Y.
Deposit date:2016-10-03
Release date:2017-08-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13
Sci Rep, 7, 2017
8HVS
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BU of 8hvs by Molmil
Solution Structure of the Antimicrobial Peptide HT-2
Descriptor: ARG-PHE-LEU-ARG-ARG-ILE-PHE-PHE-PHE-PHE
Authors:Li, S, Yang, A.
Deposit date:2022-12-27
Release date:2023-10-25
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Design and evaluation of tadpole-like conformational antimicrobial peptides.
Commun Biol, 6, 2023
8HZ5
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BU of 8hz5 by Molmil
The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus
Descriptor: Biotin carboxylase
Authors:Shen, J, Wu, W, Xu, X.
Deposit date:2023-01-08
Release date:2024-01-10
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity.
Mbio, 15, 2024
6JM5
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BU of 6jm5 by Molmil
Crystal structure of TBC1D23 C terminal domain
Descriptor: SODIUM ION, TBC1 domain family member 23
Authors:Sun, Q, Huang, W.
Deposit date:2019-03-07
Release date:2019-10-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Proc.Natl.Acad.Sci.USA, 116, 2019
8HZ4
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BU of 8hz4 by Molmil
The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate
Descriptor: Biotin carboxylase
Authors:Shen, J, Wu, W, Xu, X.
Deposit date:2023-01-08
Release date:2024-01-10
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity.
Mbio, 15, 2024
7FAT
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BU of 7fat by Molmil
Structure Determination of the RBD-NB1A7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, nb_1A7
Authors:Geng, Y, Shi, Z.Z, Li, X.Y, Wang, L, Sun, Z.C, Zhang, H.W, Chen, X.C.
Deposit date:2021-07-07
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural basis of nanobodies neutralizing SARS-CoV-2 variants
Structure, 30, 2022
7F32
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BU of 7f32 by Molmil
Ny-Hydroxyasparagine: A Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases
Descriptor: SYCNCLCRRGVCRCICTI
Authors:Xia, Y, Liu, C.F.
Deposit date:2021-06-15
Release date:2022-09-07
Method:SOLUTION NMR
Cite:N gamma-Hydroxyasparagine: A Multifunctional Unnatural Amino Acid That is a Good P1 Substrate of Asparaginyl Peptide Ligases.
Angew.Chem.Int.Ed.Engl., 60, 2021
2FDV
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BU of 2fdv by Molmil
Microsomal P450 2A6 with the inhibitor N-Methyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound
Descriptor: 1,2-ETHANEDIOL, Cytochrome P450 2A6, N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, ...
Authors:Yano, J.K, Stout, C.D, Johnson, E.F.
Deposit date:2005-12-14
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization.
J.Med.Chem., 49, 2006
8J5P
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BU of 8j5p by Molmil
Cryo-EM structure of native RC-LH complex from Roseiflexus castenholzii at 2,000lux
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 2-methyl-3-[(2E,6E,10E,14E,18E,22E,26E,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,1 4,18,22,26,30,34,38,42-undecaen-1-yl]naphthalene-1,4-dione, Alpha subunit of light-harvesting 1, ...
Authors:Xu, X, Xin, J.
Deposit date:2023-04-24
Release date:2023-09-20
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture.
Elife, 12, 2023
8J5O
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BU of 8j5o by Molmil
Cryo-EM structure of native RC-LH complex from Roseiflexus castenholzii at 100lux
Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 2-methyl-3-[(2E,6E,10E,14E,18E,22E,26E,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,1 4,18,22,26,30,34,38,42-undecaen-1-yl]naphthalene-1,4-dione, Alpha subunit of light-harvesting 1, ...
Authors:Xu, X, Xin, J.
Deposit date:2023-04-24
Release date:2023-09-20
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture.
Elife, 12, 2023
5HZ5
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BU of 5hz5 by Molmil
FABP5 in complex with 6-Chloro-4-phenyl-2-piperidin-1-yl-3-(1H-tetrazol-5-yl)-quinoline
Descriptor: 6-chloro-4-phenyl-2-(piperidin-1-yl)-3-(1H-tetrazol-5-yl)quinoline, DIMETHYL SULFOXIDE, Fatty acid-binding protein, ...
Authors:Ehler, A, Rudolph, M.G.
Deposit date:2016-02-02
Release date:2017-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Bioorg. Med. Chem. Lett., 26, 2016
2FDY
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BU of 2fdy by Molmil
Microsomal P450 2A6 with the inhibitor Adrithiol bound
Descriptor: 4,4'-DIPYRIDYL DISULFIDE, Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Yano, J.K, Stout, C.D, Johnson, E.F.
Deposit date:2005-12-14
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization.
J.Med.Chem., 49, 2006
8XC4
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BU of 8xc4 by Molmil
Nipah virus attachment glycoprotein head domain in complex with a broadly neutralizing antibody 1E5
Descriptor: 1E5-VH, 1E5-VL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fan, P.F, Yu, C.M, Chen, W.
Deposit date:2023-12-08
Release date:2024-01-24
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:A potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer.
Nat Commun, 15, 2024
2MNZ
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BU of 2mnz by Molmil
NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa)
Descriptor: H3K4me0, Lysine-specific demethylase 5B, ZINC ION
Authors:Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C.
Deposit date:2014-04-16
Release date:2014-08-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Protein Cell, 5, 2014
5HZ6
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BU of 5hz6 by Molmil
FABP4 in complex with 6-Chloro-2-isopropyl-4-(3-isopropyl-phenyl)-quinoline-3-carboxylic acid
Descriptor: 6-Chloro-2-isopropyl-4-(3-isopropyl-phenyl)-quinoline-3-carboxylic acid, Fatty acid-binding protein, adipocyte
Authors:Ehler, A, Rudolph, M.G.
Deposit date:2016-02-02
Release date:2016-12-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.
Bioorg. Med. Chem. Lett., 26, 2016
7CU8
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BU of 7cu8 by Molmil
Crystal structure of the soluble domain of TiME protein from Mycobacterium tuberculosis
Descriptor: SULFATE ION, Tube-forming protein in Mycobacterial Envelope (TiME)
Authors:Gong, W, Cai, X, Liu, L, Wen, C.
Deposit date:2020-08-21
Release date:2021-08-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Identification and architecture of a putative secretion tube across mycobacterial outer envelope.
Sci Adv, 7, 2021
7CU9
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BU of 7cu9 by Molmil
Crystal structure of the soluble domain of TiME protein from Mycobacterium smegmatis
Descriptor: GLYCEROL, MAGNESIUM ION, Tube-forming protein in Mycobacterial Envelpe, ...
Authors:Gong, W, Cai, X, Liu, L, Wen, C.
Deposit date:2020-08-21
Release date:2021-08-25
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification and architecture of a putative secretion tube across mycobacterial outer envelope.
Sci Adv, 7, 2021
6KYF
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BU of 6kyf by Molmil
Crystal structure of an anti-CRISPR protein
Descriptor: AcrF11, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Niu, Y, Wang, H, Zhang, Y, Feng, Y.
Deposit date:2019-09-18
Release date:2020-09-23
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation.
Mol.Cell, 80, 2020
1OO3
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BU of 1oo3 by Molmil
P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase
Descriptor: Phosphatidylinositol 3-kinase regulatory alpha subunit
Authors:Guenther, U.L, Weyrauch, B, Schaffhausen, B.
Deposit date:2003-03-03
Release date:2003-03-25
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity
Biochemistry, 42, 2003

223532

数据于2024-08-07公开中

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