6BT6

CTX-M-14 S237A Beta-Lactamase in Complex with a Non-Covalent Tetrazole Inhibitor

Summary for 6BT6

Entry DOI	10.2210/pdb6bt6/pdb
Descriptor	Beta-lactamase, N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-benzimidazole-4-carboxamide (3 entities in total)
Functional Keywords	tetrazole, inhibitor, beta-lactamase, esbl, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	57428.20
Authors	Pemberton, O.A.,Chen, Y. (deposition date: 2017-12-05, release date: 2018-06-13, Last modification date: 2023-10-04)
Primary citation	Pemberton, O.A.,Zhang, X.,Nichols, D.A.,DeFrees, K.,Jaishankar, P.,Bonnet, R.,Adams, J.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta-Lactamases. Antimicrob. Agents Chemother., 62:-, 2018 Cited by PubMed: 29844038 DOI: 10.1128/AAC.02563-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation