6BU3

CTX-M-27 Beta-Lactamase in Complex with a Non-Covalent Tetrazole Inhibitor

Summary for 6BU3

Related6BT6
DescriptorBeta-lactamase, N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-benzimidazole-4-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordstetrazole, inhibitor, beta-lactamase, esbl, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceEscherichia coli
Total number of polymer chains2
Total molecular weight57780.37
Authors
Pemberton, O.A.,Chen, Y. (deposition date: 2017-12-08, release date: 2018-06-13)
Primary citation
Pemberton, O.A.,Zhang, X.,Nichols, D.A.,DeFrees, K.,Jaishankar, P.,Bonnet, R.,Adams, J.,Shaw, L.N.,Renslo, A.R.,Chen, Y.
Antibacterial spectrum of a tetrazole-based reversible inhibitor of serine beta-lactamases.
Antimicrob. Agents Chemother., 2018
PubMed: 29844038 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.02563-17
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.16620.4%0.7%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6bu3
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Molmil generated image of 6bu3
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More Biological unit images

Molmil generated image of 6bu3
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Molmil generated image of 6bu3
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Molmil generated image of 6bu3
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6bu3.pdb1.gz [104.17 KB])
Coordinate files for Biological unit (6bu3.pdb2.gz [102.24 KB])
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