6BU3

CTX-M-27 Beta-Lactamase in Complex with a Non-Covalent Tetrazole Inhibitor

Summary for 6BU3

• Entry DOI: 10.2210/pdb6bu3/pdb
• Related: 6BT6
• Descriptor: Beta-lactamase, N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-benzimidazole-4-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: tetrazole, inhibitor, beta-lactamase, esbl, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57780.37

Authors

Pemberton, O.A.,Chen, Y. (deposition date: 2017-12-08, release date: 2018-06-13, Last modification date: 2023-10-04)

• Primary citation: Pemberton, O.A.,Zhang, X.,Nichols, D.A.,DeFrees, K.,Jaishankar, P.,Bonnet, R.,Adams, J.,Shaw, L.N.,Renslo, A.R.,Chen, Y.; Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine beta-Lactamases.; Antimicrob. Agents Chemother., 62:-, 2018; PubMed: 29844038; DOI: 10.1128/AAC.02563-17

Experimental method

X-RAY DIFFRACTION (1.15 Å)