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Structure of bovine anti-HIV Fab Bess7
Descriptor:	Bovine Fab Bess7 heavy chain, Bovine Fab Bess7 light chain
Authors:	Stanfield, R.L, Wilson, I.A.
Deposit date:	2023-12-12
Release date:	2024-09-04
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024

8V2E

Crystal structure of B055 scaffold boost immunogen in complex with a mature 10E8 Fab
Descriptor:	10E8 EPITOPE SCAFFOLD B055, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 10E8 FAB HEAVY CHAIN, ...
Authors:	Cho, S.Y, Wilson, I.A.
Deposit date:	2023-11-22
Release date:	2024-06-12
Method:	X-RAY DIFFRACTION (2.62 Å)
Cite:	Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat.Immunol., 25, 2024

8U44

CryoEM structure of A/Solomon Islands/3/2006 H1 HA in complex with 05.GC.w2.3C10-H1_SI06
Descriptor:	05.GC.w2.3C10-H1_SI06 Heavy chain, 05.GC.w2.3C10-H1_SI06 Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Moore, N, Han, J, Ward, A.B, Wilson, I.A.
Deposit date:	2023-09-08
Release date:	2024-06-26
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (3.41 Å)
Cite:	Persistence of germinal center B cell responses after influenza virus vaccination in humans To Be Published

5CCK

Crystal structure of Human anti-HIV-1 broadly neutralizing antibody 3BC315 Fab
Descriptor:	3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Antibody 3BC315 Fab heavy chain, Antibody 3BC315 Fab light chain
Authors:	Lee, J.H, Ward, A.B, Wilson, I.A.
Deposit date:	2015-07-02
Release date:	2015-10-07
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun, 6, 2015

5CJQ

Crystal structure of a trimeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114
Descriptor:	CR9114 heavy chain, CR9114 light chain, Designed influenza hemagglutinin stem #4900, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-07-14
Release date:	2015-09-09
Last modified:	2015-09-30
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science, 349, 2015

5CEX

Crystal Structure of Fab 32H+109L, a putative precursor of the PGT121 family of potent HIV-1 antibodies
Descriptor:	Antibody 9H+3L Fab heavy chain, Antibody 9H+3L Fab light chain, GLYCEROL, ...
Authors:	Garces, F, Wilson, I.A.
Deposit date:	2015-07-07
Release date:	2015-12-23
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.105 Å)
Cite:	Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity, 43, 2015

5CJS

Crystal structure of a monomeric influenza hemagglutinin stem in complex with an broadly neutralizing antibody CR9114
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 heavy chain, CR9114 light chain, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-07-15
Release date:	2015-09-09
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (4.3 Å)
Cite:	A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science, 349, 2015

5E30

Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1) with LSTc
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-10-01
Release date:	2015-12-02
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E35

Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1) with LSTc
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-10-01
Release date:	2015-12-02
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E34

Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1) with LSTa
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-10-01
Release date:	2015-12-02
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E2Y

Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, beta-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-10-01
Release date:	2015-12-02
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E99

Bovine Fab fragment F08_B11
Descriptor:	Fab F08_B11 heavy chain, Fab F08_B11 light chain
Authors:	Stanfield, R.L, Wilson, I.A.
Deposit date:	2015-10-14
Release date:	2016-08-24
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.06 Å)
Cite:	Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies. Sci Immunol, 1, 2016

5E32

Crystal structure of H5 hemagglutinin mutant (N224K, Q226L, N158D and L133a deletion) from the influenza virus A/chicken/Vietnam/NCVD-093/2008 (H5N1)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-10-01
Release date:	2015-12-02
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5E2Z

Crystal structure of H5 hemagglutinin Q226L mutant from the influenza virus A/duck/Egypt/10185SS/2010 (H5N1) with LSTa
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2015-10-01
Release date:	2015-12-02
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.624 Å)
Cite:	Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Rep, 13, 2015

5XRT

Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Zhang, H, Wilson, I.A.
Deposit date:	2017-06-09
Release date:	2018-07-25
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun, 9, 2018

5XRS

Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin in complex with LSTc
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ...
Authors:	Zhang, H, Wilson, I.A.
Deposit date:	2017-06-09
Release date:	2018-07-25
Last modified:	2022-10-12
Method:	X-RAY DIFFRACTION (2.907 Å)
Cite:	A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun, 9, 2018

5YL9

1.86 Angstrom crystal structure of human Coronavirus 229E fusion core
Descriptor:	Spike glycoprotein
Authors:	Yang, B, Yan, L, Meng, B, WIlson, I.A.
Deposit date:	2017-10-17
Release date:	2018-09-26
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (1.861 Å)
Cite:	Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 angstrom resolution Acta Crystallogr D Struct Biol, 74, 2018

5ZUV

Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1
Descriptor:	CHLORIDE ION, Spike glycoprotein,Spike glycoprotein,inhibitor EK1
Authors:	Yan, L, Yang, B, Wilson, I.A.
Deposit date:	2018-05-08
Release date:	2019-04-10
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.21 Å)
Cite:	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv, 5, 2019

5ZVM

Crystal Structure of the Human Coronavirus SARS HR1 motif in complex with pan-CoVs inhibitor EK1
Descriptor:	Spike glycoprotein, pan-CoV inhibitory peptide EK1
Authors:	Yan, L, Yang, B, Wilson, I.A.
Deposit date:	2018-05-11
Release date:	2019-04-10
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv, 5, 2019

5ZVK

Crystal Structure of the Human Coronavirus MERS HR1 motif in complex with pan-CoVs inhibitor EK1
Descriptor:	Human Coronavirus MERS HR1 motif, pan-CoV inhibitory peptide EK1
Authors:	Yan, L, Yang, B, Wilson, I.A.
Deposit date:	2018-05-11
Release date:	2019-04-10
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (3.31 Å)
Cite:	A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv, 5, 2019

5ZV3

Crystal structure of human anti-tau antibody CBTAU-28.1 in complex with its tau peptide
Descriptor:	Heavy chain of antibody CBTAU28.1, Light chain (kappa) of antibody CBTAU28.1, Peptide from Microtubule-associated protein tau
Authors:	Zhang, H, Wilson, I.A.
Deposit date:	2018-05-09
Release date:	2018-06-20
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.093 Å)
Cite:	A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities. Acta Neuropathol Commun, 6, 2018

6AVN

Crystal structure of unbound anti-HIV antibody Fab PGV19 at 2.5 A
Descriptor:	GLYCEROL, PENTAETHYLENE GLYCOL, PGV19 Fab heavy chain, ...
Authors:	Sarkar, A, Wilson, I.A.
Deposit date:	2017-09-03
Release date:	2018-06-27
Last modified:	2024-10-09
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nat Commun, 9, 2018

6AOP

Crystal structure of the A/Brisbane/10/2007 (H3N2) influenza virus hemagglutinin L194P mutant apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-08-16
Release date:	2017-10-18
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathog., 13, 2017

6AOS

Crystal structure of the A/Brisbane/10/2007 (H3N2) influenza virus hemagglutinin L194P mutant in complex with 3'-SLNLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-08-16
Release date:	2017-10-18
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathog., 13, 2017

6AOQ

Crystal structure of the A/Brisbane/10/2007 (H3N2) influenza virus hemagglutinin apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA2 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-08-16
Release date:	2017-10-18
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS Pathog., 13, 2017

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