2BTP
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![BU of 2btp by Molmil](/molmil-images/mine/2btp) | 14-3-3 Protein Theta (Human) Complexed to Peptide | Descriptor: | 14-3-3 PROTEIN TAU, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS | Authors: | Elkins, J.M, Johansson, A.C.E, Smee, C, Yang, X, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A, Structural Genomics Consortium (SGC) | Deposit date: | 2005-06-05 | Release date: | 2005-06-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
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4NBM
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![BU of 4nbm by Molmil](/molmil-images/mine/4nbm) | Crystal structure of UVB photoreceptor UVR8 and light-induced structural changes at 180K | Descriptor: | MAGNESIUM ION, Ultraviolet-B receptor UVR8 | Authors: | Yang, X, Zeng, X, Zhao, K.-H, Ren, Z. | Deposit date: | 2013-10-23 | Release date: | 2016-10-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Dynamic Crystallography Reveals Early Signalling Events in Ultraviolet Photoreceptor UVR8. Nat Plants, 1, 2015
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4NAA
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![BU of 4naa by Molmil](/molmil-images/mine/4naa) | Crystal structure of UVB photoreceptor UVR8 from Arabidopsis thaliana and UV-induced structural changes at 120K | Descriptor: | MAGNESIUM ION, Ultraviolet-B receptor UVR8 | Authors: | Yang, X, Zeng, X, Ren, Z, Zhao, K.H. | Deposit date: | 2013-10-22 | Release date: | 2016-10-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Dynamic Crystallography Reveals Early Signalling Events in Ultraviolet Photoreceptor UVR8. Nat Plants, 1, 2015
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4NC4
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![BU of 4nc4 by Molmil](/molmil-images/mine/4nc4) | Crystal structure of photoreceptor AtUVR8 mutant W285F and light-induced structural changes at 120K | Descriptor: | MAGNESIUM ION, Ultraviolet-B receptor UVR8 | Authors: | Yang, X, Zeng, X, Zhao, K.-H, Ren, Z. | Deposit date: | 2013-10-23 | Release date: | 2016-10-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Dynamic Crystallography Reveals Early Signalling Events in Ultraviolet Photoreceptor UVR8. Nat Plants, 1, 2015
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2IC5
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![BU of 2ic5 by Molmil](/molmil-images/mine/2ic5) | Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ugochukwu, E, Yang, X, Zao, Y, Elkins, J, Gileadi, C, Burgess, N, Colebrook, S, Gileadi, O, Fedorov, O, Bunkoczi, G, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Doyle, D, Structural Genomics Consortium (SGC) | Deposit date: | 2006-09-12 | Release date: | 2006-10-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. To be Published
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5XGH
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![BU of 5xgh by Molmil](/molmil-images/mine/5xgh) | Crystal structure of PI3K complex with an inhibitor | Descriptor: | 3-[(4-fluorophenyl)methylamino]-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | Authors: | Song, K, Yang, X, Zhao, Y, Jian, Z. | Deposit date: | 2017-04-13 | Release date: | 2018-04-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | New Insights into PI3K Inhibitor Design using X-ray Structures of PI3K alpha Complexed with a Potent Lead Compound. Sci Rep, 7, 2017
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2ODB
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![BU of 2odb by Molmil](/molmil-images/mine/2odb) | The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6) | Descriptor: | CHLORIDE ION, Human Cell Division Cycle 42 (CDC42), MAGNESIUM ION, ... | Authors: | Ugochukwu, E, Yang, X, Elkins, J, Soundararajan, M, Pike, A.C.W, Eswaran, J, Burgess, N, Debreczeni, J.E, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Gileadi, O, von Delft, F, Knapp, S, Doyle, D, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-22 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6) To be Published
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7C2M
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![BU of 7c2m by Molmil](/molmil-images/mine/7c2m) | Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with NITD-349 | Descriptor: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, Chimera of drug exporters of the RND superfamily-like protein and Endolysin, N-(4,4-dimethylcyclohexyl)-4,6-bis(fluoranyl)-1H-indole-2-carboxamide, ... | Authors: | Zhang, B, Yang, X, Hu, T, Rao, Z. | Deposit date: | 2020-05-08 | Release date: | 2020-12-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO. J.Mol.Biol., 432, 2020
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7C2N
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![BU of 7c2n by Molmil](/molmil-images/mine/7c2n) | Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with SPIRO | Descriptor: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 1'-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)spiro[6,7-dihydrothieno[3,2-c]pyran-4,4'-piperidine], Drug exporters of the RND superfamily-like protein,Endolysin, ... | Authors: | Zhang, B, Yang, X, Hu, T, Rao, Z. | Deposit date: | 2020-05-08 | Release date: | 2020-12-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO. J.Mol.Biol., 432, 2020
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8STB
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![BU of 8stb by Molmil](/molmil-images/mine/8stb) | The structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX | Descriptor: | CHLORIDE ION, GLYCEROL, Glyoxalase, ... | Authors: | Luo, Z, Jia, X, Yan, X, Qu, X, Kobe, B. | Deposit date: | 2023-05-09 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | The crystal structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX. To Be Published
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1M4X
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![BU of 1m4x by Molmil](/molmil-images/mine/1m4x) | PBCV-1 virus capsid, quasi-atomic model | Descriptor: | PBCV-1 virus capsid | Authors: | Nandhagopal, N, Simpson, A.A, Gurnon, J.R, Yan, X, Baker, T.S, Graves, M.V, Van Etten, J.L, Rossmann, M.G. | Deposit date: | 2002-07-05 | Release date: | 2002-12-04 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (28 Å) | Cite: | The Structure and Evolution of the Major Capsid Protein of a Large,
Lipid containing, DNA virus. Proc.Natl.Acad.Sci.USA, 99, 2002
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8EPY
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![BU of 8epy by Molmil](/molmil-images/mine/8epy) | The solution structure of abxF in complex with its product (-)-ABX, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX | Descriptor: | (6R,16R)-3,11,13,15-tetrahydroxy-1,6,9,9-tetramethyl-6,7,9,16-tetrahydro-14H-6,16-epoxyanthra[2,3-e]benzo[b]oxocin-14-one, Glyoxalase | Authors: | Jia, X, Yan, X, Qu, X, Mobli, M. | Deposit date: | 2022-10-06 | Release date: | 2024-04-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The solution structure of abxF, an enzyme catalyzing the formation of chiral spiroketal of an antibiotics, (-)-ABX. To Be Published
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7YNX
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![BU of 7ynx by Molmil](/molmil-images/mine/7ynx) | Crystal structure of Pirh2 bound to poly-Ala peptide | Descriptor: | RING finger and CHY zinc finger domain-containing protein 1, SODIUM ION, SULFATE ION, ... | Authors: | Dong, C, Yan, X, Li, Y. | Deposit date: | 2022-08-01 | Release date: | 2023-04-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Recognition of an Ala-rich C-degron by the E3 ligase Pirh2. Nat Commun, 14, 2023
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2X7I
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![BU of 2x7i by Molmil](/molmil-images/mine/2x7i) | Crystal structure of mevalonate kinase from methicillin-resistant Staphylococcus aureus MRSA252 | Descriptor: | CHLORIDE ION, CITRIC ACID, MEVALONATE KINASE | Authors: | Oke, M, Yan, X, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H. | Deposit date: | 2010-02-27 | Release date: | 2010-07-21 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Scottish Structural Proteomics Facility: Targets, Methods and Outputs. J.Struct.Funct.Genomics, 11, 2010
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6DXK
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![BU of 6dxk by Molmil](/molmil-images/mine/6dxk) | Glucocorticoid Receptor in complex with Compound 11 | Descriptor: | (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name), Glucocorticoid receptor | Authors: | Rew, Y, Du, X, Eksterowicz, J, Zhou, H, Jahchan, N, Zhu, L, Yan, X, Kawai, H, McGee, L.R, Medina, J.C, Huang, T, Chen, C, Zavorotinskaya, T, Sutimantanapi, D, Waszczuk, J, Jackson, E, Huang, E, Ye, Q, Fantin, V.R, Daqing, S. | Deposit date: | 2018-06-29 | Release date: | 2018-10-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101). J. Med. Chem., 61, 2018
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8EO9
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![BU of 8eo9 by Molmil](/molmil-images/mine/8eo9) | The solution structure of abxF, an enzyme catalyzing the formation of chiral spiroketal of an antibiotics, (-)-ABX | Descriptor: | Glyoxalase | Authors: | Jia, X, Yan, X, Mobli, M, Qu, X. | Deposit date: | 2022-10-02 | Release date: | 2024-04-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The solution structure of abxF, an enzyme catalyzing the formation of chiral spiroketal of an antibiotics, (-)-ABX. To Be Published
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7Y3A
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![BU of 7y3a by Molmil](/molmil-images/mine/7y3a) | Crystal structure of TRIM7 bound to 2C | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-2C | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y3B
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![BU of 7y3b by Molmil](/molmil-images/mine/7y3b) | Crystal structure of TRIM7 bound to GN1 | Descriptor: | E3 ubiquitin-protein ligase TRIM7,TRIM7-GN1 | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
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7Y3C
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![BU of 7y3c by Molmil](/molmil-images/mine/7y3c) | Crystal structure of TRIM7 bound to RACO-1 | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-RACO-1 | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
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8KDB
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![BU of 8kdb by Molmil](/molmil-images/mine/8kdb) | Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form | Descriptor: | MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... | Authors: | Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. | Deposit date: | 2023-08-09 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
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8KDC
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![BU of 8kdc by Molmil](/molmil-images/mine/8kdc) | Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form | Descriptor: | MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... | Authors: | Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. | Deposit date: | 2023-08-09 | Release date: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
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6OVH
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![BU of 6ovh by Molmil](/molmil-images/mine/6ovh) | Cryo-EM structure of Bimetallic dodecameric cage design 3 (BMC3) from cytochrome cb562 | Descriptor: | ACETOHYDROXAMIC ACID, FE (III) ION, HEME C, ... | Authors: | Golub, E, Subramanian, R.H, Yan, X, Alberstein, R.G, Tezcan, F.A. | Deposit date: | 2019-05-07 | Release date: | 2020-01-29 | Last modified: | 2020-02-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Constructing protein polyhedra via orthogonal chemical interactions. Nature, 578, 2020
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3OKG
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![BU of 3okg by Molmil](/molmil-images/mine/3okg) | Crystal structure of HsdS subunit from Thermoanaerobacter tengcongensis | Descriptor: | Restriction endonuclease S subunits, SULFATE ION | Authors: | Liang, D, Gao, P, Tang, Q, An, X, Yan, X. | Deposit date: | 2010-08-24 | Release date: | 2011-05-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of HsdS subunit from Thermoanaerobacter tengcongensis sheds lights on mechanism of dynamic opening and closing of type I methyltransferase Plos One, 6, 2011
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6CLW
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![BU of 6clw by Molmil](/molmil-images/mine/6clw) | Crystal structure of TnmH | Descriptor: | O-methyltransferase | Authors: | Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B. | Deposit date: | 2018-03-02 | Release date: | 2019-03-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. J.Med.Chem., 63, 2020
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6CLX
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![BU of 6clx by Molmil](/molmil-images/mine/6clx) | Crystal structure of TnmH in complex with SAM | Descriptor: | O-methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B. | Deposit date: | 2018-03-02 | Release date: | 2019-03-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. J.Med.Chem., 63, 2020
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