8EPY

The solution structure of abxF in complex with its product (-)-ABX, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX

Summary for 8EPY

• Entry DOI: 10.2210/pdb8epy/pdb
• NMR Information: BMRB: 31046
• Descriptor: Glyoxalase, (6R,16R)-3,11,13,15-tetrahydroxy-1,6,9,9-tetramethyl-6,7,9,16-tetrahydro-14H-6,16-epoxyanthra[2,3-e]benzo[b]oxocin-14-one (2 entities in total)
• Functional Keywords: cyana 3.98.13, enzyme, catalysis, chiral spiroketal, biosynthetic protein-antibiotic complex, biosynthetic protein/antibiotic
• Biological source: Streptomyces sp.
• Total number of polymer chains: 1
• Total formula weight: 25652.45

Authors

Jia, X.,Yan, X.,Qu, X.,Mobli, M. (deposition date: 2022-10-06, release date: 2024-04-10, Last modification date: 2025-04-23)

• Primary citation: Jia, X.,Yan, X.,Mobli, M.,Qu, X.; An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone; Nat.Chem., 2025

Experimental method

SOLUTION NMR