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4EB8
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BU of 4eb8 by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Descriptor: 1,2-ETHANEDIOL, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ...
Authors:Ho, M.C, Haapalainen, A.M, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-23
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
4ECE
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BU of 4ece by Molmil
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine
Descriptor: GUANINE, Purine nucleoside phosphorylase
Authors:Haapalainen, A.M, Ho, M.C, Suarez, J.J, Almo, S.C, Schramm, V.L.
Deposit date:2012-03-26
Release date:2013-02-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.
Chem.Biol., 20, 2013
4F2P
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BU of 4f2p by Molmil
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[2-(2-hydroxyethoxy)ethyl]sulfanyl}methyl)pyrrolidin-3- ol, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ...
Authors:Haapalainen, A.M, Thomas, K, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2012-05-08
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A
Structure, 21, 2013
4F1W
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BU of 4f1w by Molmil
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with Adenine
Descriptor: 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE, ...
Authors:Haapalainen, A.M, Thomas, K, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2012-05-07
Release date:2013-05-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with Adenine
Structure, 21, 2013
4F2W
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BU of 4f2w by Molmil
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A
Descriptor: (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ...
Authors:Haapalainen, A.M, Thomas, K, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2012-05-08
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A
Structure, 21, 2013
4F3K
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BU of 4f3k by Molmil
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A
Descriptor: 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, {(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-hydroxypyrrolidin-3-yl}-L-methionine
Authors:Haapalainen, A.M, Thomas, K, Bonanno, J.B, Almo, S.C, Schramm, V.L.
Deposit date:2012-05-09
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with homocysteine-DADMe-Immucillin-A
Structure, 21, 2013
3FZ0
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BU of 3fz0 by Molmil
Inosine-Guanosine Nucleoside Hydrolase (IG-NH)
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Nucleoside hydrolase, ...
Authors:Vandemeulebroucke, A, Minici, C, Bruno, I, Muzzolini, L, Tornaghi, P, Parkin, D.W, Schramm, V.L, Versees, W, Steyaert, J, Degano, M.
Deposit date:2009-01-23
Release date:2010-01-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei
Biochemistry, 49, 2010
5TC6
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BU of 5tc6 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with propylthio-immucillin-A
Descriptor: (2S,3S,4R,5S)-2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(propylsulfanyl)methyl]pyrrolidine-3,4-diol, CHLORIDE ION, GLYCEROL, ...
Authors:Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
Deposit date:2016-09-14
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:TBA
To be published
5TC7
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BU of 5tc7 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom
Descriptor: 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
Deposit date:2016-09-14
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:TBA
To be published
5TC8
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BU of 5tc8 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with methylthio-DADMe-Immucillin-A
Descriptor: (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
Deposit date:2016-09-14
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:TBA
To be published
5TC5
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BU of 5tc5 by Molmil
Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with butylthio-DADMe-Immucillin-A and chloride
Descriptor: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, CHLORIDE ION, S-methyl-5'-thioadenosine phosphorylase
Authors:Cameron, S.A, Firestone, R.S, Schramm, V.L, Almo, S.C.
Deposit date:2016-09-14
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:TBA
To be published
7L1A
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BU of 7l1a by Molmil
Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALANINE, MAGNESIUM ION, ...
Authors:Niland, C.N, Fedorov, E, Schramm, V.L, Ghosh, A.
Deposit date:2020-12-14
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A.
Biochemistry, 60, 2021
5DK6
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BU of 5dk6 by Molmil
CRYSTAL STRUCTURE OF A 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE (MTA/SAH) NUCLEOSIDASE (MTAN) FROM COLWELLIA PSYCHRERYTHRAEA 34H (CPS_4743, TARGET PSI-029300) IN COMPLEX WITH ADENINE AT 2.27 A RESOLUTION
Descriptor: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE, GLYCINE
Authors:Himmel, D.M, Bhosle, R, Toro, R, Ahmed, M, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Love, J, Fiser, A, Seidel, R.D, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2015-09-03
Release date:2015-11-04
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:CRYSTAL STRUCTURE OF A 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE (MTA/SAH)NUCLEOSIDASE (MTAN) FROM COLWELLIA PSYCHRERYTHRAEA 34H (CPS_4743, TARGET PSI-029300) IN COMPLEX WITH ADENINE AT 2.27 A RESOLUTION
To be published
1Q8F
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BU of 1q8f by Molmil
Crystal Structure of the E.coli pyrimidine nucleoside hydrolase yeiK
Descriptor: CALCIUM ION, GLYCEROL, Pyrimidine nucleoside hydrolase
Authors:Giabbai, B, Degano, M.
Deposit date:2003-08-21
Release date:2004-05-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure to 1.7 a of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy.
STRUCTURE, 12, 2004
8SWS
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BU of 8sws by Molmil
Structure of K. lactis PNP S42E-H98R variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate
Descriptor: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION
Authors:Fedorov, E, Ghosh, A.
Deposit date:2023-05-19
Release date:2023-10-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
8SWR
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BU of 8swr by Molmil
Structure of K. lactis PNP S42E variant bound to transition state analog DADMe-IMMUCILLIN G and sulfate
Descriptor: 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, GUANINE, Purine nucleoside phosphorylase, ...
Authors:Fedorov, E, Ghosh, A.
Deposit date:2023-05-19
Release date:2023-10-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
8SWP
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BU of 8swp by Molmil
Structure of K. lactis PNP bound to hypoxanthine
Descriptor: ACETATE ION, HYPOXANTHINE, Purine nucleoside phosphorylase
Authors:Fedorov, E, Ghosh, A.
Deposit date:2023-05-19
Release date:2023-10-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
8SWU
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BU of 8swu by Molmil
Structure of Clostridium perfringens PNP bound to transition state analog IMMUCILLIN H and sulfate
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase, SULFATE ION
Authors:Fedorov, E, Ghosh, A.
Deposit date:2023-05-19
Release date:2023-10-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
8SWQ
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BU of 8swq by Molmil
Structure of K. lactis PNP bound to transition state analog DADMe-IMMUCILLIN H and sulfate
Descriptor: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, GLYCEROL, Purine nucleoside phosphorylase, ...
Authors:Fedorov, E, Ghosh, A.
Deposit date:2023-05-19
Release date:2023-10-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
8SWT
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BU of 8swt by Molmil
Structure of Bacteroides fragilis PNP bound to transition state analog IMMUCILLIN H and sulfate
Descriptor: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase, SULFATE ION
Authors:Fedorov, E, Ghosh, A.
Deposit date:2023-05-19
Release date:2023-10-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry, 62, 2023
4R31
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BU of 4r31 by Molmil
Crystal structure of a putative uridine phosphorylase from Actinobacillus succinogenes 130Z (Target NYSGRC-029667 )
Descriptor: GLYCEROL, Uridine phosphorylase
Authors:Sampathkumar, P, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-08-13
Release date:2014-08-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a putative uridine phosphorylase from Actinobacillus succinogenes 130Z (Target NYSGRC-029667 )
to be published
4RQB
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BU of 4rqb by Molmil
Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target ID NYSGRC-029686) from Staphylococcus aureus (tetragonal space group)
Descriptor: CHLORIDE ION, GLYCEROL, Hypoxanthine phosphoribosyltransferase, ...
Authors:Ghosh, A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-10-31
Release date:2014-11-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target ID NYSGRC-029686) from Staphylococcus aureus (tetragonal space group)
To be Published
4RQA
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BU of 4rqa by Molmil
Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target ID NYSGRC-029686) from Staphylococcus aureus (orthorhombic space group)
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Ghosh, A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-10-31
Release date:2014-11-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of a Hypoxanthine Phosphoribosyltransferase (target ID NYSGRC-029686) from Staphylococcus aureus (orthorhombic space group)
To be Published
1Z3A
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BU of 1z3a by Molmil
Crystal structure of tRNA adenosine deaminase TadA from Escherichia coli
Descriptor: ZINC ION, tRNA-specific adenosine deaminase
Authors:Malashkevich, V, Kim, J, Lisbin, M, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2005-03-10
Release date:2006-02-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase.
Biochemistry, 45, 2006
4LDN
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BU of 4ldn by Molmil
Crystal structure of a putative purine nucleoside phosphorylase from Vibrio fischeri ES114 (Target NYSGRC-029521)
Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type
Authors:Sampathkumar, P, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2013-06-24
Release date:2013-07-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of a putative purine nucleoside phosphorylase from Vibrio fischeri ES114 (Target NYSGRC-029521)
to be published

221716

数据于2024-06-26公开中

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