7L1A
Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)
Summary for 7L1A
| Entry DOI | 10.2210/pdb7l1a/pdb |
| Descriptor | S-adenosylmethionine synthase isoform type-2, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total) |
| Functional Keywords | s-adenosylmethionine, sam synthetase, enzyme mechanism, inhibitor, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 47149.43 |
| Authors | Niland, C.N.,Fedorov, E.,Schramm, V.L.,Ghosh, A. (deposition date: 2020-12-14, release date: 2021-03-17, Last modification date: 2023-10-18) |
| Primary citation | Niland, C.N.,Ghosh, A.,Cahill, S.M.,Schramm, V.L. Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. Biochemistry, 60:791-801, 2021 Cited by PubMed: 33656855DOI: 10.1021/acs.biochem.0c00998 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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