7L1A
Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-adenosylmethionine synthase isoform type-2 | polymer | 417 | 46279.4 | 1 | UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) | Homo sapiens (Human) | AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 3 | D (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 4 | E (A) | N,N'-(dihydroxy-lambda~5~-phosphanediyl)bis(phosphoramidic acid) | non-polymer | 258.0 | 1 | Chemie (XE1) | |||
| 5 | F (A) | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) PubChem (149) PubChem (439176) PubChem (688097) PubChem (6541356) PubChem (13101165) PubChem (13101166) PubChem (25322898) PubChem (40467850) PubChem (44264468) PubChem (46874793) PubChem (51397472) PubChem (99302) PubChem (51397471) PubChem (453683) PubChem (98100246) PubChem (57104771) PubChem (58108938) PubChem (58682801) PubChem (59099797) PubChem (91614589) PubChem (124300729) PubChem (124300795) PubChem (134694842) PubChem (138107656) PubChem (164077596) | |||
| 6 | G (A) | ALANINE | non-polymer | 89.1 | 1 | Chemie (ALA) | |||
| 7 | H, I, J, K, L... (A) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) PubChem (923) | |||
| 8 | N (A) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A: 1 - 395 (UniProt: P31153)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 46279.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 870.1 | |
| All* | Total formula weight | 47149.4 |
