2H9V
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![BU of 2h9v by Molmil](/molmil-images/mine/2h9v) | Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632 | Descriptor: | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE, Rho-associated protein kinase 2 | Authors: | Yamaguchi, H, Miwa, Y, Kasa, M, Kitano, K, Amano, M, Kaibuchi, K, Hakoshima, T. | Deposit date: | 2006-06-12 | Release date: | 2006-12-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632 J.Biochem.(Tokyo), 140, 2006
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1IS8
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![BU of 1is8 by Molmil](/molmil-images/mine/1is8) | Crystal structure of rat GTPCHI/GFRP stimulatory complex plus Zn | Descriptor: | GTP Cyclohydrolase I, GTP Cyclohydrolase I Feedback Regulatory Protein, PHENYLALANINE, ... | Authors: | Maita, N, Okada, K, Hatakeyama, K, Hakoshima, T. | Deposit date: | 2001-11-18 | Release date: | 2002-02-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc.Natl.Acad.Sci.USA, 99, 2002
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1UL1
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![BU of 1ul1 by Molmil](/molmil-images/mine/1ul1) | Crystal structure of the human FEN1-PCNA complex | Descriptor: | Flap endonuclease-1, MAGNESIUM ION, Proliferating cell nuclear antigen | Authors: | Sakurai, S, Kitano, K, Yamaguchi, H, Hamada, K, Okada, K, Fukuda, K, Uchida, M, Ohtsuka, E, Morioka, H, Hakoshima, T. | Deposit date: | 2003-09-05 | Release date: | 2005-03-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for recruitment of human flap endonuclease 1 to PCNA EMBO J., 24, 2005
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5XFL
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![BU of 5xfl by Molmil](/molmil-images/mine/5xfl) | |
1WPL
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![BU of 1wpl by Molmil](/molmil-images/mine/1wpl) | Crystal structure of the inhibitory form of rat GTP cyclohydrolase I/GFRP complex | Descriptor: | 7,8-DIHYDROBIOPTERIN, GTP cyclohydrolase I, GTP cyclohydrolase I feedback regulatory protein, ... | Authors: | Maita, N, Hatakeyama, K, Okada, K, Hakoshima, T. | Deposit date: | 2004-09-08 | Release date: | 2004-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein J.Biol.Chem., 279, 2004
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1WE0
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![BU of 1we0 by Molmil](/molmil-images/mine/1we0) | Crystal structure of peroxiredoxin (AhpC) from Amphibacillus xylanus | Descriptor: | AMMONIUM ION, alkyl hydroperoxide reductase C | Authors: | Kitano, K, Kita, A, Hakoshima, T, Niimura, Y, Miki, K. | Deposit date: | 2004-05-21 | Release date: | 2005-03-29 | Last modified: | 2018-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of decameric peroxiredoxin (AhpC) from Amphibacillus xylanus Proteins, 59, 2005
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5Y04
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1VTW
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![BU of 1vtw by Molmil](/molmil-images/mine/1vtw) | AT Base Pairs Are Less Stable than GC Base Pairs in Z-DNA: The Crystal Structure of D(M(5)CGTAM(5)CG) | Descriptor: | DNA (5'-D(*(CH3)CP*GP*TP*AP*(CH3)CP*G)-3') | Authors: | Wang, A.H.-J, Hakoshima, T, Van Der Marel, G.A, Van Boom, J.H, Rich, A. | Deposit date: | 1988-08-18 | Release date: | 2011-07-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | AT Base Pairs Are Less Stable than GC Base Pairs in Z-DNA: The Crystal Structure of d(m(5)CGTAm(5)CG) Cell(Cambridge,Mass.), 37, 1984
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1VTG
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![BU of 1vtg by Molmil](/molmil-images/mine/1vtg) | THE MOLECULAR STRUCTURE OF A DNA-TRIOSTIN A COMPLEX | Descriptor: | 2-CARBOXYQUINOXALINE, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), triostin A | Authors: | Wang, A.H.-J, Ughetto, G, Quigley, G.J, Hakoshima, T, Van Der Marel, G.A, Van Boom, J.H, Rich, A. | Deposit date: | 1988-08-18 | Release date: | 2011-07-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | The molecular structure of a DNA-triostin A complex. Science, 225, 1984
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2ZSH
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![BU of 2zsh by Molmil](/molmil-images/mine/2zsh) | Structural basis of gibberellin(GA3)-induced DELLA recognition by the gibberellin receptor | Descriptor: | DELLA protein GAI, GIBBERELLIN A3, Probable gibberellin receptor GID1L1 | Authors: | Murase, K, Hirano, Y, Sun, T.P, Hakoshima, T. | Deposit date: | 2008-09-10 | Release date: | 2008-11-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Gibberellin-induced DELLA recognition by the gibberellin receptor GID1 Nature, 456, 2008
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2ZSI
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![BU of 2zsi by Molmil](/molmil-images/mine/2zsi) | Structural basis of gibberellin(GA4)-induced DELLA recognition by the gibberellin receptor | Descriptor: | DELLA protein GAI, GIBBERELLIN A4, Probable gibberellin receptor GID1L1 | Authors: | Murase, K, Hirano, Y, Sun, T.P, Hakoshima, T. | Deposit date: | 2008-09-10 | Release date: | 2008-11-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Gibberellin-induced DELLA recognition by the gibberellin receptor GID1 Nature, 456, 2008
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336D
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![BU of 336d by Molmil](/molmil-images/mine/336d) | INTERACTION BETWEEN LEFT-HANDED Z-DNA AND POLYAMINE-3 THE CRYSTAL STRUCTURE OF THE D(CG)3 AND THERMOSPERMINE COMPLEX | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), MAGNESIUM ION, N-(3-AMINO-PROPYL)-N-(5-AMINOPROPYL)-1,4-DIAMINOBUTANE | Authors: | Ohishi, H, Terasoma, N, Nakanishi, I, Van Der Marel, G, Van Boom, J.H, Rich, A, Wang, A.H.-J, Hakoshima, T, Tomita, K.-I. | Deposit date: | 1997-06-24 | Release date: | 1998-04-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Interaction between left-handed Z-DNA and polyamine - 3. The crystal structure of the d(CG)3 and thermospermine complex. FEBS Lett., 398, 1996
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3AAF
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![BU of 3aaf by Molmil](/molmil-images/mine/3aaf) | Structure of WRN RQC domain bound to double-stranded DNA | Descriptor: | ACETATE ION, DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3'), Werner syndrome ATP-dependent helicase | Authors: | Kitano, K, Hakoshima, T. | Deposit date: | 2009-11-16 | Release date: | 2010-02-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN Structure, 18, 2010
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3AH8
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![BU of 3ah8 by Molmil](/molmil-images/mine/3ah8) | Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Nishimura, A, Kitano, K, Takasaki, J, Taniguchi, M, Mizuno, N, Tago, K, Hakoshima, T, Itoh, H. | Deposit date: | 2010-04-20 | Release date: | 2010-07-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule. Proc.Natl.Acad.Sci.USA, 107, 2010
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3W9R
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![BU of 3w9r by Molmil](/molmil-images/mine/3w9r) | Crystal structure of the high-affinity abscisic acid receptor PYL9/RCAR9 bound to ABA | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL9, HEXAETHYLENE GLYCOL | Authors: | Nakagawa, M, Hirano, Y, Kagiyama, M, Shibata, N, Hakoshima, T. | Deposit date: | 2013-04-13 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism of high-affinity abscisic acid binding to PYL9/RCAR1. Genes Cells, 19, 2014
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3WE2
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3WE3
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![BU of 3we3 by Molmil](/molmil-images/mine/3we3) | |
6A1C
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![BU of 6a1c by Molmil](/molmil-images/mine/6a1c) | Crystal structure of the CK2a1-go289 complex | Descriptor: | 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-4-[(E)-(3-methylsulfanyl-5-phenyl-1,2,4-triazol-4-yl)iminomethyl]phenol, Casein kinase II subunit alpha, ... | Authors: | Kinoshita, T, Tsuyuguchi, M. | Deposit date: | 2018-06-07 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv, 5, 2019
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5XNF
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![BU of 5xnf by Molmil](/molmil-images/mine/5xnf) | Crystal structure of the branched-chain polyamine synthase (BpsA) from Thermococcus kodakarensis | Descriptor: | FE (III) ION, GLYCEROL, N(4)-bis(aminopropyl)spermidine synthase, ... | Authors: | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | Deposit date: | 2017-05-22 | Release date: | 2018-08-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine. FEBS J., 284, 2017
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6KX4
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![BU of 6kx4 by Molmil](/molmil-images/mine/6kx4) | |
6KX6
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![BU of 6kx6 by Molmil](/molmil-images/mine/6kx6) | Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound | Descriptor: | Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | Deposit date: | 2019-09-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16, 2020
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6LUE
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![BU of 6lue by Molmil](/molmil-images/mine/6lue) | Crystal structure of mouse Cryptochrome 1 in complex with compound KL201 | Descriptor: | 2-bromanyl-N-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)benzamide, Cryptochrome-1 | Authors: | Miller, S, Aikawa, Y, Hirota, T. | Deposit date: | 2020-01-27 | Release date: | 2020-06-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chem Biol, 27, 2020
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7D1C
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![BU of 7d1c by Molmil](/molmil-images/mine/7d1c) | Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 | Descriptor: | Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide | Authors: | Miller, S.A, Hirota, T. | Deposit date: | 2020-09-14 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
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7D19
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1C52
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![BU of 1c52 by Molmil](/molmil-images/mine/1c52) | THERMUS THERMOPHILUS CYTOCHROME-C552: A NEW HIGHLY THERMOSTABLE CYTOCHROME-C STRUCTURE OBTAINED BY MAD PHASING | Descriptor: | CYTOCHROME-C552, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Than, M.E, Hof, P, Huber, R, Bourenkov, G.P, Bartunik, H.D, Buse, G, Soulimane, T. | Deposit date: | 1997-06-23 | Release date: | 1998-06-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Thermus thermophilus cytochrome-c552: A new highly thermostable cytochrome-c structure obtained by MAD phasing. J.Mol.Biol., 271, 1997
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