7W2D
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7W2F
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8JED
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![BU of 8jed by Molmil](/molmil-images/mine/8jed) | Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors | Descriptor: | mRNA-capping enzyme regulatory subunit OPG124 | Authors: | Wang, D, Zhao, R, Shu, W, Hu, W, Wang, M, Cao, J, Zhou, X. | Deposit date: | 2023-05-15 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors. Int.J.Biol.Macromol., 253, 2023
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8JIX
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5U6I
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![BU of 5u6i by Molmil](/molmil-images/mine/5u6i) | Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity | Descriptor: | 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W. | Deposit date: | 2016-12-08 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J. Med. Chem., 60, 2017
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5TJB
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![BU of 5tjb by Molmil](/molmil-images/mine/5tjb) | I-II linker of TRPML1 channel at pH 4.5 | Descriptor: | Mucolipin-1 | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | Deposit date: | 2016-10-04 | Release date: | 2017-01-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat. Struct. Mol. Biol., 24, 2017
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5TJA
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![BU of 5tja by Molmil](/molmil-images/mine/5tja) | I-II linker of TRPML1 channel at pH 6 | Descriptor: | Mucolipin-1 | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | Deposit date: | 2016-10-04 | Release date: | 2017-01-25 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat. Struct. Mol. Biol., 24, 2017
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5TJC
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![BU of 5tjc by Molmil](/molmil-images/mine/5tjc) | I-II linker of TRPML1 channel at pH 7.5 | Descriptor: | Mucolipin-1 | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | Deposit date: | 2016-10-04 | Release date: | 2017-01-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat. Struct. Mol. Biol., 24, 2017
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4ZS3
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![BU of 4zs3 by Molmil](/molmil-images/mine/4zs3) | Structural complex of 5-aminofluorescein bound to the FTO protein | Descriptor: | 2-OXOGLUTARIC ACID, 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | Authors: | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | Deposit date: | 2015-05-13 | Release date: | 2015-11-04 | Last modified: | 2015-11-18 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein J.Am.Chem.Soc., 137, 2015
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4ZS2
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![BU of 4zs2 by Molmil](/molmil-images/mine/4zs2) | Structural complex of FTO/fluorescein | Descriptor: | 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID, 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | Authors: | Wang, T, Hong, T, Huang, Y, Yang, C.G, Zhou, X. | Deposit date: | 2015-05-13 | Release date: | 2015-11-04 | Last modified: | 2015-11-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein J.Am.Chem.Soc., 137, 2015
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4Z0B
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![BU of 4z0b by Molmil](/molmil-images/mine/4z0b) | Crystal Structure of the Fab Fragment of Anti-ofloxacin Antibody and Exploration Its Receptor Binding Site | Descriptor: | PHOSPHATE ION, antibody heavy chain, antibody light chain | Authors: | He, K, Du, X, Sheng, W, Zhou, X, Wang, J, Wang, S. | Deposit date: | 2015-03-26 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal Structure of the Fab Fragment of an Anti-ofloxacin Antibody and Exploration of Its Specific Binding. J.Agric.Food Chem., 64, 2016
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7F5X
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![BU of 7f5x by Molmil](/molmil-images/mine/7f5x) | GK domain of Drosophila P5CS filament with glutamate | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, GAMMA-L-GLUTAMIC ACID | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2021-06-23 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7F5V
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![BU of 7f5v by Molmil](/molmil-images/mine/7f5v) | Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2021-06-22 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7F5U
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7F5T
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![BU of 7f5t by Molmil](/molmil-images/mine/7f5t) | Drosophila P5CS filament with glutamate | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, GLUTAMIC ACID | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2021-06-22 | Release date: | 2022-05-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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8GS8
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![BU of 8gs8 by Molmil](/molmil-images/mine/8gs8) | cryo-EM structure of the human respiratory complex II | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | Authors: | Du, Z, Zhou, X, Lai, Y, Xu, J, Zhang, Y, Zhou, S, Liu, F, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2022-09-05 | Release date: | 2023-05-10 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure of the human respiratory complex II. Proc.Natl.Acad.Sci.USA, 120, 2023
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3HH7
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![BU of 3hh7 by Molmil](/molmil-images/mine/3hh7) | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra) | Descriptor: | Muscarinic toxin-like protein 3 homolog | Authors: | Roy, A, Zhou, X, Chong, M.Z, D'hoedt, D, Foo, C.S, Rajagopalan, N, Nirthanan, S, Bertrand, D, Sivaraman, J, Kini, R.M. | Deposit date: | 2009-05-15 | Release date: | 2010-01-12 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra) J.Biol.Chem., 285, 2010
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4GAZ
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![BU of 4gaz by Molmil](/molmil-images/mine/4gaz) | Crystal Structure of a Jumonji Domain-containing Protein JMJD5 | Descriptor: | Lysine-specific demethylase 8, N-OXALYLGLYCINE, NICKEL (II) ION | Authors: | Wang, H, Zhou, X, Zhang, X, Tao, Y, Chen, N, Zang, J. | Deposit date: | 2012-07-26 | Release date: | 2013-08-14 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Crystal Structure of a Jumonji Domain-containing Protein JMJD5 To be Published
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8HUZ
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6LO8
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![BU of 6lo8 by Molmil](/molmil-images/mine/6lo8) | Cryo-EM structure of the TIM22 complex from yeast | Descriptor: | Mitochondrial import inner membrane translocase subunit TIM10, Mitochondrial import inner membrane translocase subunit TIM12, Mitochondrial import inner membrane translocase subunit TIM18, ... | Authors: | Zhang, Y, Zhou, X, Wu, X, Li, L. | Deposit date: | 2020-01-04 | Release date: | 2020-09-30 | Last modified: | 2021-03-17 | Method: | ELECTRON MICROSCOPY (3.83 Å) | Cite: | Structure of the mitochondrial TIM22 complex from yeast. Cell Res., 31, 2021
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2F4M
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![BU of 2f4m by Molmil](/molmil-images/mine/2f4m) | The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs | Descriptor: | CHLORIDE ION, UV excision repair protein RAD23 homolog B, ZINC ION, ... | Authors: | Zhao, G, Zhou, X, Wang, L, Kisker, C, Lennarz, W.J, Schindelin, H. | Deposit date: | 2005-11-23 | Release date: | 2006-03-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J.Biol.Chem., 281, 2006
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2F4O
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![BU of 2f4o by Molmil](/molmil-images/mine/2f4o) | The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs | Descriptor: | CHLORIDE ION, PHQ-VAL-ALA-ASP-CF0, XP-C repair complementing complex 58 kDa protein, ... | Authors: | Zhao, G, Zhou, X, Wang, L, Kisker, C, Lennarz, W.J, Schindelin, H. | Deposit date: | 2005-11-23 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J.Biol.Chem., 281, 2006
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2HPL
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![BU of 2hpl by Molmil](/molmil-images/mine/2hpl) | Crystal structure of the mouse p97/PNGase complex | Descriptor: | C-terminal of mouse p97/VCP, PNGase | Authors: | Zhao, G, Zhou, X, Wang, L, Li, G, Lennarz, W, Schindelin, H. | Deposit date: | 2006-07-17 | Release date: | 2007-05-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2HPJ
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![BU of 2hpj by Molmil](/molmil-images/mine/2hpj) | Crystal structure of the PUB domain of mouse PNGase | Descriptor: | GLYCEROL, PNGase | Authors: | Zhao, G, Zhou, X, Wang, L, Li, G, Lennarz, W, Schindelin, H. | Deposit date: | 2006-07-17 | Release date: | 2007-05-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc.Natl.Acad.Sci.Usa, 104, 2007
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6LGY
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![BU of 6lgy by Molmil](/molmil-images/mine/6lgy) | Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with glycine and sodium | Descriptor: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCINE, NONAETHYLENE GLYCOL, ... | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | Deposit date: | 2019-12-06 | Release date: | 2020-12-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.247 Å) | Cite: | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii. Acta Crystallogr D Struct Biol, 77, 2021
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