7W2F

An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by co-crystallization

Summary for 7W2F

Entry DOI	10.2210/pdb7w2f/pdb
Descriptor	Sigma non-opioid intracellular receptor 1, 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	sigma receptor, membrane receptor, s1r, ligand entry, membrane protein
Biological source	Xenopus laevis (African clawed frog)
Total number of polymer chains	12
Total formula weight	307315.84
Authors	Meng, F.,Sun, Z.,Zhou, X. (deposition date: 2021-11-23, release date: 2022-03-16, Last modification date: 2023-11-29)
Primary citation	Meng, F.,Xiao, Y.,Ji, Y.,Sun, Z.,Zhou, X. An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway. Nat Commun, 13:1267-1267, 2022 Cited by PubMed: 35273182 DOI: 10.1038/s41467-022-28946-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation