7W2F

An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by co-crystallization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005640	cellular_component	nuclear outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0038023	molecular_function	signaling receptor activity
A	0043523	biological_process	regulation of neuron apoptotic process
A	1905897	biological_process	regulation of response to endoplasmic reticulum stress
B	0005635	cellular_component	nuclear envelope
B	0005637	cellular_component	nuclear inner membrane
B	0005640	cellular_component	nuclear outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0038023	molecular_function	signaling receptor activity
B	0043523	biological_process	regulation of neuron apoptotic process
B	1905897	biological_process	regulation of response to endoplasmic reticulum stress
C	0005635	cellular_component	nuclear envelope
C	0005637	cellular_component	nuclear inner membrane
C	0005640	cellular_component	nuclear outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0038023	molecular_function	signaling receptor activity
C	0043523	biological_process	regulation of neuron apoptotic process
C	1905897	biological_process	regulation of response to endoplasmic reticulum stress
D	0005635	cellular_component	nuclear envelope
D	0005637	cellular_component	nuclear inner membrane
D	0005640	cellular_component	nuclear outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0038023	molecular_function	signaling receptor activity
D	0043523	biological_process	regulation of neuron apoptotic process
D	1905897	biological_process	regulation of response to endoplasmic reticulum stress
E	0005635	cellular_component	nuclear envelope
E	0005637	cellular_component	nuclear inner membrane
E	0005640	cellular_component	nuclear outer membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0014069	cellular_component	postsynaptic density
E	0016020	cellular_component	membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0038023	molecular_function	signaling receptor activity
E	0043523	biological_process	regulation of neuron apoptotic process
E	1905897	biological_process	regulation of response to endoplasmic reticulum stress
F	0005635	cellular_component	nuclear envelope
F	0005637	cellular_component	nuclear inner membrane
F	0005640	cellular_component	nuclear outer membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0014069	cellular_component	postsynaptic density
F	0016020	cellular_component	membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0038023	molecular_function	signaling receptor activity
F	0043523	biological_process	regulation of neuron apoptotic process
F	1905897	biological_process	regulation of response to endoplasmic reticulum stress
G	0005635	cellular_component	nuclear envelope
G	0005637	cellular_component	nuclear inner membrane
G	0005640	cellular_component	nuclear outer membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0014069	cellular_component	postsynaptic density
G	0016020	cellular_component	membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0038023	molecular_function	signaling receptor activity
G	0043523	biological_process	regulation of neuron apoptotic process
G	1905897	biological_process	regulation of response to endoplasmic reticulum stress
H	0005635	cellular_component	nuclear envelope
H	0005637	cellular_component	nuclear inner membrane
H	0005640	cellular_component	nuclear outer membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0014069	cellular_component	postsynaptic density
H	0016020	cellular_component	membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0038023	molecular_function	signaling receptor activity
H	0043523	biological_process	regulation of neuron apoptotic process
H	1905897	biological_process	regulation of response to endoplasmic reticulum stress
I	0005635	cellular_component	nuclear envelope
I	0005637	cellular_component	nuclear inner membrane
I	0005640	cellular_component	nuclear outer membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0014069	cellular_component	postsynaptic density
I	0016020	cellular_component	membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0038023	molecular_function	signaling receptor activity
I	0043523	biological_process	regulation of neuron apoptotic process
I	1905897	biological_process	regulation of response to endoplasmic reticulum stress
J	0005635	cellular_component	nuclear envelope
J	0005637	cellular_component	nuclear inner membrane
J	0005640	cellular_component	nuclear outer membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0014069	cellular_component	postsynaptic density
J	0016020	cellular_component	membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0038023	molecular_function	signaling receptor activity
J	0043523	biological_process	regulation of neuron apoptotic process
J	1905897	biological_process	regulation of response to endoplasmic reticulum stress
K	0005635	cellular_component	nuclear envelope
K	0005637	cellular_component	nuclear inner membrane
K	0005640	cellular_component	nuclear outer membrane
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0014069	cellular_component	postsynaptic density
K	0016020	cellular_component	membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0038023	molecular_function	signaling receptor activity
K	0043523	biological_process	regulation of neuron apoptotic process
K	1905897	biological_process	regulation of response to endoplasmic reticulum stress
L	0005635	cellular_component	nuclear envelope
L	0005637	cellular_component	nuclear inner membrane
L	0005640	cellular_component	nuclear outer membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0014069	cellular_component	postsynaptic density
L	0016020	cellular_component	membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0038023	molecular_function	signaling receptor activity
L	0043523	biological_process	regulation of neuron apoptotic process
L	1905897	biological_process	regulation of response to endoplasmic reticulum stress

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	264
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	Region: {"description":"Important for ligand-binding","evidences":[{"source":"UniProtKB","id":"Q60492","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Site: {"description":"Important for ligand binding","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---