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7RHM
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BU of 7rhm by Molmil
Structure of Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer
Descriptor: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION
Authors:Bester, S.M, Kvaratskhelia, M.
Deposit date:2021-07-17
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Mbio, 13, 2022
7RMJ
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BU of 7rmj by Molmil
Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor (S)-N-(1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide
Descriptor: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION, ...
Authors:Bester, S.M, Kvaratskhelia, M.
Deposit date:2021-07-27
Release date:2022-08-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Mbio, 13, 2022
7RMM
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BU of 7rmm by Molmil
Structure of N74D mutant of disulfide stabilized HIV-1 CA hexamer
Descriptor: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION
Authors:Bester, S.M, Kvaratskhelia, M.
Deposit date:2021-07-27
Release date:2022-08-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Mbio, 13, 2022
4CGC
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BU of 4cgc by Molmil
Crystal structure of the trimerization domain of human EML4
Descriptor: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4
Authors:Richards, M.W, Bayliss, R.
Deposit date:2013-11-21
Release date:2014-12-10
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Microtubule Association of Eml Proteins and the Eml4-Alk Variant 3 Oncoprotein Require an N-Terminal Trimerization Domain.
Biochem.J., 467, 2015
8A1P
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BU of 8a1p by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P.
Deposit date:2022-06-01
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Mbio, 14, 2023
8A1Q
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BU of 8a1q by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir)
Descriptor: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, 1,2-ETHANEDIOL, Integrase, ...
Authors:Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P.
Deposit date:2022-06-01
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Mbio, 14, 2023
6B19
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BU of 6b19 by Molmil
Architecture of HIV-1 reverse transcriptase initiation complex core
Descriptor: RNA genome fragment, reverse transcriptase p51 subunit, reverse transcriptase p66 subunit, ...
Authors:Larsen, K.P, Mathiharan, Y.K, Chen, D.H, Puglisi, J.D, Skiniotis, G, Puglisi, E.V.
Deposit date:2017-09-18
Release date:2018-04-25
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Architecture of an HIV-1 reverse transcriptase initiation complex.
Nature, 557, 2018
4CGB
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BU of 4cgb by Molmil
Crystal structure of the trimerization domain of EML2
Descriptor: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2, GLYCEROL, POTASSIUM ION
Authors:Richards, M.W, Bayliss, R.
Deposit date:2013-11-21
Release date:2014-12-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.154 Å)
Cite:Microtubule Association of Eml Proteins and the Eml4-Alk Variant 3 Oncoprotein Require an N-Terminal Trimerization Domain.
Biochem.J., 467, 2015
7SNQ
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BU of 7snq by Molmil
Hexamer HIV-1 CA in complex with CPSF6 peptide and IP6 ligand
Descriptor: CHLORIDE ION, Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6, ...
Authors:Bester, S.M, Kvaratskhelia, M.
Deposit date:2021-10-28
Release date:2022-09-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.
Nat Commun, 13, 2022
4CI8
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BU of 4ci8 by Molmil
Crystal structure of the tandem atypical beta-propeller domain of EML1
Descriptor: ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1, SULFATE ION
Authors:Richards, M.W, Bayliss, R.
Deposit date:2013-12-06
Release date:2014-04-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Eml1 Reveals the Basis for Hsp90 Dependence of Oncogenic Eml4-Alk by Disruption of an Atypical Beta-Propeller Domain.
Proc.Natl.Acad.Sci.USA, 111, 2014
6I2I
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BU of 6i2i by Molmil
Refined 13pf Hela Cell Tubulin microtubule (EML4-NTD decorated)
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Atherton, J.M, Moores, C.A.
Deposit date:2018-11-01
Release date:2019-08-28
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.
Sci.Signal., 12, 2019
3IF6
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BU of 3if6 by Molmil
Crystal structure of OXA-46 beta-lactamase from P. aeruginosa
Descriptor: 1,2-ETHANEDIOL, HEXAETHYLENE GLYCOL, L(+)-TARTARIC ACID, ...
Authors:Docquier, J.D, Benvenuti, M, Calderone, V, Giuliani, F, Kapetis, D, De Luca, F, Rossolini, G.M, Mangani, S.
Deposit date:2009-07-24
Release date:2010-03-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates
Antimicrob.Agents Chemother., 54, 2010
2WQO
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BU of 2wqo by Molmil
STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950
Descriptor: 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2
Authors:Mas-Droux, C, Bayliss, R.
Deposit date:2009-08-24
Release date:2009-12-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.167 Å)
Cite:An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9.
Mol.Cell, 36, 2009
2WQN
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BU of 2wqn by Molmil
Structure of ADP-bound human Nek7
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ...
Authors:Richards, M.W, Bayliss, R.
Deposit date:2009-08-24
Release date:2009-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9.
Mol.Cell, 36, 2009
6U4K
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BU of 6u4k by Molmil
Human talin2 residues 1-403
Descriptor: Talin-2
Authors:Izard, T, Rangarajan, E.S, Colgan, L, Yasuda, R, Chinthalapudi, K.
Deposit date:2019-08-26
Release date:2020-07-08
Last modified:2020-09-23
Method:X-RAY DIFFRACTION (2.555 Å)
Cite:A distinct talin2 structure directs isoform specificity in cell adhesion.
J.Biol.Chem., 295, 2020
2WQM
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BU of 2wqm by Molmil
Structure of apo human Nek7
Descriptor: NICKEL (II) ION, SERINE/THREONINE-PROTEIN KINASE NEK7, SULFATE ION
Authors:Richards, M.W, Bayliss, R.
Deposit date:2009-08-24
Release date:2009-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An Auto-Inhibitory Tyrosine Motif in the Cell-Cycle Regulated Nek7 Kinase is Released Through Binding of Nek9
Mol.Cell, 36, 2009
4NE5
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BU of 4ne5 by Molmil
Human MHF1-MHF2 complex
Descriptor: Centromere protein S, Centromere protein X
Authors:Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y.
Deposit date:2013-10-28
Release date:2013-12-25
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
5DH5
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BU of 5dh5 by Molmil
PDE10 complexed with N-[(1-methylpyrazol-4-yl)methyl]-5-[[(1S,2S)-2-(2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine
Descriptor: MAGNESIUM ION, N-[(1-methyl-1H-pyrazol-4-yl)methyl]-5-{[(1S,2S)-2-(pyridin-2-yl)cyclopropyl]methoxy}pyrazolo[1,5-a]pyrimidin-7-amine, ZINC ION, ...
Authors:Yan, Y.
Deposit date:2015-08-29
Release date:2016-01-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg.Med.Chem.Lett., 26, 2016
5DE2
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BU of 5de2 by Molmil
Structural mechanism of Nek7 activation by Nek9-induced dimerisation
Descriptor: Serine/threonine-protein kinase Nek7, Serine/threonine-protein kinase Nek9
Authors:Haq, T, Bayliss, R.
Deposit date:2015-08-25
Release date:2015-11-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Nat Commun, 6, 2015
4NE6
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BU of 4ne6 by Molmil
Human MHF1-MHF2 complex
Descriptor: Centromere protein S, Centromere protein X
Authors:Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y.
Deposit date:2013-10-28
Release date:2013-12-25
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.1001 Å)
Cite:The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
5DH4
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BU of 5dh4 by Molmil
PDE10 complexed with 5-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine
Descriptor: 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione, 5-chloro-N-[(2,4-dimethyl-1,3-thiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine, MAGNESIUM ION, ...
Authors:Yan, Y.
Deposit date:2015-08-29
Release date:2016-01-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg.Med.Chem.Lett., 26, 2016
4NE1
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BU of 4ne1 by Molmil
Human MHF1 MHF2 DNA complexes
Descriptor: Centromere protein S, Centromere protein X, DNA (26-MER)
Authors:Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y.
Deposit date:2013-10-28
Release date:2014-01-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (6.499 Å)
Cite:The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
4NDY
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BU of 4ndy by Molmil
Human MHF1-MHF2 DNA complex
Descriptor: Centromere protein S, Centromere protein X, DNA (26-MER)
Authors:Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y.
Deposit date:2013-10-28
Release date:2014-01-22
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (6.999 Å)
Cite:The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
4NE3
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BU of 4ne3 by Molmil
Human MHF1-MHF2 complex
Descriptor: Centromere protein S, Centromere protein X
Authors:Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y.
Deposit date:2013-10-28
Release date:2013-12-25
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.8007 Å)
Cite:The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
2QKD
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BU of 2qkd by Molmil
Crystal structure of tandem ZPR1 domains
Descriptor: FORMIC ACID, ZINC ION, Zinc finger protein ZPR1
Authors:Mishra, A.K.
Deposit date:2007-07-10
Release date:2007-08-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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数据于2024-06-26公开中

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