7ROU
| Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr | Descriptor: | SULFATE ION, Tyrosine--tRNA ligase, cytoplasmic, ... | Authors: | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2021-08-02 | Release date: | 2022-06-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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7ROR
| Plasmodium falciparum tyrosyl-tRNA synthetase in complex with tyrosine-AMP | Descriptor: | 5'-O-[(S)-{[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]oxy}(hydroxy)phosphoryl]adenosine, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2021-08-02 | Release date: | 2022-06-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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7ROT
| Plasmodium falciparum tyrosyl-tRNA synthetase, S234C mutant, in complex with ML901-Tyr | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Tyrosine--tRNA ligase, ... | Authors: | Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2021-08-02 | Release date: | 2022-06-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376, 2022
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4Y7R
| Crystal structure of WDR5 in complex with MYC MbIIIb peptide | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MYC MbIIIb peptide, ... | Authors: | Sun, Q, Phan, J, Olejniczak, E.T, Thomas, L.R, Fesik, S.W, Tansey, W.P. | Deposit date: | 2015-02-16 | Release date: | 2015-04-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC. Mol.Cell, 58, 2015
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5YSC
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3USX
| Crystal structure of PGRP-S complexed with Myristic Acid at 2.28 A resolution | Descriptor: | GLYCEROL, MYRISTIC ACID, Peptidoglycan recognition protein 1 | Authors: | Yamini, S, Sharma, P, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2011-11-24 | Release date: | 2012-01-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site Arch.Biochem.Biophys., 529, 2013
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3UMQ
| Crystal structure of peptidoglycan recognition protein-S complexed with butyric acid at 2.2 A resolution | Descriptor: | GLYCEROL, Peptidoglycan recognition protein 1, butanoic acid | Authors: | Pandey, N, Sharma, P, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2011-11-14 | Release date: | 2012-07-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site Arch.Biochem.Biophys., 529, 2013
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3UIL
| Crystal Structure of the complex of PGRP-S with lauric acid at 2.2 A resolution | Descriptor: | GLYCEROL, LAURIC ACID, Peptidoglycan recognition protein 1 | Authors: | Dube, D, Sharma, P, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2011-11-05 | Release date: | 2012-07-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site Arch.Biochem.Biophys., 529, 2013
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2W29
| Gly102Thr mutant of Rv3291c | Descriptor: | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | Authors: | Shrivastava, T, Dey, S, Ravishankar, R. | Deposit date: | 2008-10-25 | Release date: | 2009-11-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Ligand-Induced Structural Transitions, Mutational Analysis, and 'Open' Quaternary Structure of the M. Tuberculosis Feast/Famine Regulatory Protein (Rv3291C). J.Mol.Biol., 392, 2009
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2G8Z
| Crystal structure of the ternary complex of signalling protein from sheep (SPS-40) with trimer and designed peptide at 2.5A resolution | Descriptor: | (TRP)(PRO)(TRP), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3-like protein 1, ... | Authors: | Ethayathulla, A.S, Srivastava, D.B, Kumar, J, Somvanshi, R.K, Sharma, S, Singh, T.P. | Deposit date: | 2006-03-04 | Release date: | 2006-04-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the ternary complex of signalling protein from sheep (SPS-40) with trimer and designed peptide at 2.5A resolution To be Published
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4DWL
| Avd molecule from Bordetella bacteriophage DGR | Descriptor: | Bbp7, PHOSPHATE ION | Authors: | Ghosh, P, Al-Ayyoubi, M. | Deposit date: | 2012-02-24 | Release date: | 2013-02-27 | Last modified: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structure of the essential diversity-generating retroelement protein bAvd and its functionally important interaction with reverse transcriptase. Structure, 21, 2013
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8QHP
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8H5V
| Crystal structure of the FleQ domain of Vibrio cholerae FlrA | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, flagellar regulatory protein A | Authors: | Dasgupta, J, Chakraborty, S. | Deposit date: | 2022-10-14 | Release date: | 2022-11-02 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The N-terminal FleQ domain of the Vibrio cholerae flagellar master regulator FlrA plays pivotal structural roles in stabilizing its active state. Febs Lett., 597, 2023
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3T2V
| Crystal structure of the complex of peptidoglycan recognition protein-short (CPGRP-S) with mycolic acid at 2.5 A resolution | Descriptor: | (2S,3R)-2-hexyl-3-hydroxynonanoic acid, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Sharma, P, Dube, D, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2011-07-23 | Release date: | 2011-08-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site Arch.Biochem.Biophys., 529, 2013
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3MU7
| Crystal structure of the xylanase and alpha-amylase inhibitor protein (XAIP-II) from scadoxus multiflorus at 1.2 A resolution | Descriptor: | DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, xylanase and alpha-amylase inhibitor protein | Authors: | Kumar, S, Singh, N, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-05-02 | Release date: | 2010-07-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Modulation of inhibitory activity of xylanase-alpha-amylase inhibitor protein (XAIP): binding studies and crystal structure determination of XAIP-II from Scadoxus multiflorus at 1.2 A resolution. Bmc Struct.Biol., 10, 2010
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4LX8
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4JP1
| Mg2+ bound structure of Vibrio Cholerae CheY3 | Descriptor: | Chemotaxis protein CheY, MAGNESIUM ION | Authors: | Biswas, M, Dasgupta, J, Sen, U. | Deposit date: | 2013-03-19 | Release date: | 2014-04-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Conformational barrier of CheY3 and inability of CheY4 to bind FliM control the flagellar motor action in Vibrio cholerae Plos One, 8, 2013
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4FNN
| Crystal structure of the complex of CPGRP-S with stearic acid at 2.2 A RESOLUTION | Descriptor: | Peptidoglycan recognition protein 1, STEARIC ACID | Authors: | Dube, D, Sharma, P, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2012-06-20 | Release date: | 2012-07-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site. Arch.Biochem.Biophys., 529, 2013
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8TC8
| Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate | Descriptor: | 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ... | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2023-06-30 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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8TC7
| Human asparaginyl-tRNA synthetase, apo form | Descriptor: | Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ... | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2023-06-30 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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8TC9
| Human asparaginyl-tRNA synthetase bound to OSM-S-106 | Descriptor: | Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2023-06-30 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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3TO5
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4H60
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3NG4
| Ternary complex of peptidoglycan recognition protein (PGRP-S) with Maltose and N-Acetylglucosamine at 1.7 A Resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Peptidoglycan recognition protein 1, ... | Authors: | Sharma, P, Dube, D, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-06-10 | Release date: | 2010-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Multiligand specificity of pathogen-associated molecular pattern-binding site in peptidoglycan recognition protein J.Biol.Chem., 286, 2011
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3NW3
| Crystal structure of the complex of peptidoglycan recognition protein (PGRP-S) with the PGN Fragment at 2.5 A resolution | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, ALANINE, D-GLUTAMINE, ... | Authors: | Sharma, P, Dube, D, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2010-07-09 | Release date: | 2010-08-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Multiligand specificity of pathogen-associated molecular pattern-binding site in peptidoglycan recognition protein J.Biol.Chem., 286, 2011
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