3D4B
 
 | | Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+ | | Descriptor: | 5'-O-[(R)-{[(R)-{[(3R,4R)-1-(3-carbamoylbenzyl)-4-hydroxypyrrolidin-3-yl]methoxy}(hydroxy)phosphoryl]methyl}(hydroxy)phosphoryl]adenosine, Acetyl P53 peptide, NAD-dependent deacetylase, ... | | Authors: | Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. | | Deposit date: | 2008-05-14 | | Release date: | 2008-09-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure, 16, 2008
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3D81
 | | Sir2-S-alkylamidate complex crystal structure | | Descriptor: | NAD-dependent deacetylase, S-alkylamidate intermediate, ZINC ION | | Authors: | Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. | | Deposit date: | 2008-05-22 | | Release date: | 2008-09-30 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insights into intermediate steps in the Sir2 deacetylation reaction.
Structure, 16, 2008
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1JAT
 | | Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex | | Descriptor: | Ubiquitin-Conjugating Enzyme E2-17.5 KDA, Ubiquitin-Conjugating Enzyme Variant Mms2 | | Authors: | VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. | | Deposit date: | 2001-05-31 | | Release date: | 2001-06-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
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1JBB
 | | Ubiquitin Conjugating Enzyme, Ubc13 | | Descriptor: | ubiquitin conjugating enzyme E2-17.5 KDA | | Authors: | VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. | | Deposit date: | 2001-06-03 | | Release date: | 2001-06-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.
Cell(Cambridge,Mass.), 105, 2001
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1AWC
 | | MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA | | Descriptor: | DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3'), PROTEIN (GA BINDING PROTEIN ALPHA), ... | | Authors: | Batchelor, A.H, Wolberger, C. | | Deposit date: | 1997-10-01 | | Release date: | 1998-03-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
Science, 279, 1998
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1B72
 | | PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX | | Descriptor: | DNA (5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*GP*AP*TP*CP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*CP*GP*AP*TP*CP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3'), PROTEIN (HOMEOBOX PROTEIN HOX-B1), ... | | Authors: | Piper, D.E, Batchelor, A.H, Chang, C.-P, Cleary, M.L, Wolberger, C. | | Deposit date: | 1999-01-27 | | Release date: | 1999-02-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.
Cell(Cambridge,Mass.), 96, 1999
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1ERJ
 | | CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1 | | Descriptor: | TRANSCRIPTIONAL REPRESSOR TUP1 | | Authors: | Sprague, E.R, Redd, M.J, Johnson, A.D, Wolberger, C. | | Deposit date: | 2000-04-06 | | Release date: | 2000-07-26 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
EMBO J., 19, 2000
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1K61
 | | MATALPHA2 HOMEODOMAIN BOUND TO DNA | | Descriptor: | 5'-D(*(5IU)P*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*AP*CP*AP*TP*G)-3', 5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*CP*AP*CP*GP*C)-3', Mating-type protein alpha-2 | | Authors: | Aishima, J, Gitti, R.K, Noah, J.E, Gan, H.H, Schlick, T, Wolberger, C. | | Deposit date: | 2001-10-14 | | Release date: | 2002-12-11 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A Hoogsteen base pair embedded in undistorted B-DNA
NUCLEIC ACIDS RES., 30, 2002
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1K78
 | | Pax5(1-149)+Ets-1(331-440)+DNA | | Descriptor: | C-ets-1 Protein, Paired Box Protein Pax5, Pax5/Ets Binding Site on the mb-1 promoter | | Authors: | Garvie, C.W, Hagman, J, Wolberger, C. | | Deposit date: | 2001-10-18 | | Release date: | 2002-01-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001
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1K79
 | | Ets-1(331-440)+GGAA duplex | | Descriptor: | C-ets-1 protein, DNA (5'-D(*CP*AP*CP*AP*TP*TP*TP*CP*CP*GP*GP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*CP*CP*GP*GP*AP*AP*AP*TP*GP*T)-3') | | Authors: | Garvie, C.W, Hagman, J, Wolberger, C. | | Deposit date: | 2001-10-18 | | Release date: | 2002-01-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001
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1K7A
 | | Ets-1(331-440)+GGAG duplex | | Descriptor: | C-ets-1 Protein, DNA (5'-D(*CP*AP*CP*AP*TP*CP*TP*CP*CP*GP*GP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*CP*CP*GP*GP*AP*GP*AP*TP*GP*T)-3') | | Authors: | Garvie, C.W, Hagman, J, Wolberger, C. | | Deposit date: | 2001-10-18 | | Release date: | 2002-01-04 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural studies of Ets-1/Pax5 complex formation on DNA.
Mol.Cell, 8, 2001
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1LE8
 | | Crystal Structure of the MATa1/MATalpha2-3A Heterodimer Bound to DNA Complex | | Descriptor: | 5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*CP*AP*TP*CP*A)-3', 5'-D(*TP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*AP*CP*AP*TP*G)-3', MATING-TYPE PROTEIN A-1, ... | | Authors: | Ke, A, Mathias, J.R, Vershon, A.K, Wolberger, C. | | Deposit date: | 2002-04-09 | | Release date: | 2002-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and Thermodynamic Characterization of the DNA Binding Properties of a Triple Alanine Mutant of MATalpha2
Structure, 10, 2002
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1MH3
 | | maltose binding-a1 homeodomain protein chimera, crystal form I | | Descriptor: | maltose binding-a1 homeodomain protein chimera | | Authors: | Ke, A, Wolberger, C. | | Deposit date: | 2002-08-19 | | Release date: | 2002-09-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera
Protein Sci., 12, 2003
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1MH4
 | | maltose binding-a1 homeodomain protein chimera, crystal form II | | Descriptor: | maltose binding-a1 homeodomain protein chimera | | Authors: | Ke, A, Wolberger, C. | | Deposit date: | 2002-08-19 | | Release date: | 2002-09-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera
Protein Sci., 12, 2003
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1MD0
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1MDM
 | | INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA | | Descriptor: | C-ETS-1 PROTEIN, PAIRED BOX PROTEIN PAX-5, PAX5/ETS BINDING SITE ON THE MB-1 PROMOTER | | Authors: | Garvie, C.W, Pufall, M.A, Graves, B.J, Wolberger, C. | | Deposit date: | 2002-08-07 | | Release date: | 2002-12-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | STRUCTURAL ANALYSIS OF THE AUTOINHIBITION OF ETS-1 AND ITS ROLE IN PROTEIN PARTNERSHIPS
J.Biol.Chem., 277, 2002
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1MA3
 | | Structure of a Sir2 enzyme bound to an acetylated p53 peptide | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cellular tumor antigen p53, Transcriptional regulatory protein, ... | | Authors: | Avalos, J.L, Celic, I, Muhammad, S, Cosgrove, M.S, Boeke, J.D, Wolberger, C. | | Deposit date: | 2002-07-31 | | Release date: | 2002-10-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of a Sir2 enzyme bound to an acetylated p53 peptide
Mol.Cell, 10, 2002
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2H3B
 | | Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1 | | Descriptor: | Nicotinamide phosphoribosyltransferase, SULFATE ION | | Authors: | Wang, T, Zhang, X, Bheda, P, Revollo, J.R, Imai, S.I, Wolberger, C. | | Deposit date: | 2006-05-22 | | Release date: | 2006-06-20 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme.
Nat.Struct.Mol.Biol., 13, 2006
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2JE0
 | | Crystal Structure of pp32 | | Descriptor: | ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A, GLYCEROL | | Authors: | Huyton, T, Wolberger, C. | | Deposit date: | 2007-01-12 | | Release date: | 2007-06-26 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Crystal Structure of the Tumor Suppressor Protein Pp32 (Anp32A): Structural Insights Into Anp32 Family of Proteins.
Protein Sci., 16, 2007
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2JE1
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2H2I
 | | The Structural basis of Sirtuin Substrate Affinity | | Descriptor: | (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL, NAD-dependent deacetylase, ZINC ION | | Authors: | Cosgrove, M.S, Wolberger, C. | | Deposit date: | 2006-05-18 | | Release date: | 2006-12-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
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2H2G
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2H4J
 | | Sir2-deacetylated peptide (from enzymatic turnover in crystal) | | Descriptor: | 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, NAD-dependent deacetylase, ... | | Authors: | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | | Deposit date: | 2006-05-24 | | Release date: | 2006-09-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide.
Structure, 14, 2006
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2H2D
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2H2F
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