2JE1

The crystal Structure of the tumor supressor protein pp32 (Anp32a) :structural insights into the Anp32 family of proteins

Summary for 2JE1

• Entry DOI: 10.2210/pdb2je1/pdb
• Related: 2JE0
• Descriptor: ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A, GLYCEROL (3 entities in total)
• Functional Keywords: nuclear protein, leucine-rich repeat, lrr, lanp, phapi, anp32, phosphorylation
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: P39687
• Total number of polymer chains: 4
• Total formula weight: 68013.59

Authors

Huyton, T.,Wolberger, C. (deposition date: 2007-01-12, release date: 2007-06-26, Last modification date: 2024-05-01)

Primary citation

Huyton, T.,Wolberger, C.
The Crystal Structure of the Tumor Suppressor Protein Pp32 (Anp32A): Structural Insights Into Anp32 Family of Proteins.
Protein Sci., 16:1308-, 2007

PubMed Abstract: The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.

PubMed: 17567741
DOI: 10.1110/PS.072803507

Experimental method

X-RAY DIFFRACTION (2.69 Å)