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4P7S
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BU of 4p7s by Molmil
Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine
Descriptor: 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine, Macrophage migration inhibitory factor-like protein
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-03-27
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.
J.Med.Chem., 57, 2014
4PKK
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BU of 4pkk by Molmil
Crystal structure of Macrophage Migration inhibitory factor in complex with furan-2-ylmethyl)imino methanethiol
Descriptor: (Z)-[(furan-2-ylmethyl)imino]methanethiol, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-05-14
Release date:2016-05-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of Macrophage Migration inhibitory factor with a covalent inhibitor
To Be Published
4TRU
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BU of 4tru by Molmil
Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-06-17
Release date:2015-09-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
4PLU
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BU of 4plu by Molmil
Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2014-05-19
Release date:2015-09-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
5UZY
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BU of 5uzy by Molmil
Crystal structure of N97A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2017-02-27
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
Angew. Chem. Int. Ed. Engl., 57, 2018
5V70
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BU of 5v70 by Molmil
Crystal structure of N102A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2017-03-17
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of N102A mutant of human macrophage migration inhibitory factor
To Be Published
5UMJ
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BU of 5umj by Molmil
Crystal structure of H62A mutant of human macrophage migration inhibitory factor
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION
Authors:Pantouris, G, Lolis, E.
Deposit date:2017-01-27
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.
Cell Chem Biol, 27, 2020
5UMK
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BU of 5umk by Molmil
Crystal structure of H62Y mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2017-01-27
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.
Cell Chem Biol, 27, 2020
5V73
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BU of 5v73 by Molmil
Crystal structure of N110A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2017-03-17
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal structure of N110A mutant of human macrophage migration inhibitory factor
To Be Published
5BSJ
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BU of 5bsj by Molmil
Crystal structure of S63A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-06-02
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of S63A mutant of human macrophage migration inhibitory factor
To Be Published
5EIZ
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BU of 5eiz by Molmil
Crystal structure of Y99A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-10-30
Release date:2015-11-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
Angew. Chem. Int. Ed. Engl., 2018
5BSC
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BU of 5bsc by Molmil
Crystal structure of K66A mutant of human macrophage migration inhibitory factor
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-06-01
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
5BSI
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BU of 5bsi by Molmil
Crystal structure of Y36A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-06-02
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
5BS9
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BU of 5bs9 by Molmil
Crystal structure of N109A mutant of human macrophage migration inhibitory factor
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2015-06-01
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
8SPN
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BU of 8spn by Molmil
Crystal structure of macrophage migration inhibitory factor in complex with T614
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Iguratimod, ...
Authors:Pantouris, G, Lolis, E.
Deposit date:2023-05-03
Release date:2024-05-01
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.
Mol Med, 30, 2024
2HPW
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BU of 2hpw by Molmil
Green fluorescent protein from Clytia gregaria
Descriptor: Green fluorescent protein
Authors:Stepanyuk, G, Liu, Z.J, Vysotski, S.E, Lee, J, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2006-07-17
Release date:2006-09-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of Green Fluorescent Protein from Clytia Gregaria at 1.55 A resolution
To be Published
7AJ6
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BU of 7aj6 by Molmil
LN02 Fab
Descriptor: LN02, LN02 heavy chain
Authors:Caillat, C, Fenwick, G, Pantaleo, G, Weissenhorn, W.
Deposit date:2020-09-28
Release date:2021-10-06
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:LN02 Fab
To Be Published
1ONJ
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BU of 1onj by Molmil
Crystal structure of Atratoxin-b from Chinese cobra venom of Naja atra
Descriptor: Cobrotoxin b, SULFATE ION
Authors:Lou, X, Tu, X, Pan, G, Xu, C, Fan, R, Lu, W, Deng, W, Rao, P, Teng, M, Niu, L.
Deposit date:2003-02-28
Release date:2004-02-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.555 Å)
Cite:Purification, N-terminal sequencing, crystallization and preliminary structural determination of atratoxin-b, a short-chain alpha-neurotoxin from Naja atra venom.
Acta Crystallogr.,Sect.D, 59, 2003
1JPY
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BU of 1jpy by Molmil
Crystal structure of IL-17F
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hymowitz, S.G, Filvaroff, E.H, Yin, J, Lee, J, Cai, L, Risser, P, Maruoka, M, Mao, W, Foster, J, Kelley, R, Pan, G, Gurney, A.L, de Vos, A.M, Starovasnik, M.A.
Deposit date:2001-08-03
Release date:2001-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
6Q61
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BU of 6q61 by Molmil
Pore-modulating toxins exploit inherent slow inactivation to block K+ channels
Descriptor: Kunitz-type conkunitzin-S1, SULFATE ION
Authors:Karbat, I, Gueta, H, Fine, S, Szanto, T, Hamer-Rogotner, S, Dym, O, Frolow, F, Gordon, D, Panyi, G, Gurevitz, M, Reuveny, E.
Deposit date:2018-12-10
Release date:2019-08-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Pore-modulating toxins exploit inherent slow inactivation to block K+channels.
Proc.Natl.Acad.Sci.USA, 116, 2019
8Y1L
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BU of 8y1l by Molmil
Cryo-EM structure of human N-terminally bound ATG9A-ATG2A-WIPI4 complex
Descriptor: Autophagy-related protein 2 homolog A, Autophagy-related protein 9A, WD repeat domain phosphoinositide-interacting protein 4
Authors:Wang, Y, Stjepanovic, G.
Deposit date:2024-01-25
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (7.05 Å)
Cite:Structural basis for lipid transfer by the ATG2A-ATG9A complex.
Nat.Struct.Mol.Biol., 2024
8WQR
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BU of 8wqr by Molmil
Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation
Descriptor: Activating molecule in BECN1-regulated autophagy protein 1, DNA damage-binding protein 1
Authors:Liu, M, Wang, Y, Su, M.Y, Stjepanovic, G.
Deposit date:2023-10-12
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structure of the DDB1-AMBRA1 E3 ligase receptor complex linked to cell cycle regulation.
Nat Commun, 14, 2023
5KVB
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BU of 5kvb by Molmil
The crystal structure of hexachlorocyclohexane dehydrochlorinase LinA-type3 from Novosphingobium barchaimii LL02
Descriptor: Gamma-hexachlorocyclohexane dehydrochlorinase
Authors:Dellas, N, Oakeshott, J, Pearce, S.L, Pandey, G, Pushiri, H.
Deposit date:2016-07-14
Release date:2017-07-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The crystal structure of hexachlorocyclohexane dehydrochlorinase LinA-type3 from Novosphingobium barchaimii LL02
to be published
6C23
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BU of 6c23 by Molmil
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State
Descriptor: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ...
Authors:Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E.
Deposit date:2018-01-05
Release date:2018-01-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of human PRC2 with its cofactors AEBP2 and JARID2.
Science, 359, 2018
6C24
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BU of 6c24 by Molmil
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State
Descriptor: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ...
Authors:Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E.
Deposit date:2018-01-06
Release date:2018-01-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of human PRC2 with its cofactors AEBP2 and JARID2.
Science, 359, 2018

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数据于2024-10-16公开中

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