6C24

Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State

Summary for 6C24

Entry DOI	10.2210/pdb6c24/pdb
EMDB information	7334 7335
Descriptor	Polycomb protein SUZ12, Protein Jumonji, Histone-lysine N-methyltransferase EZH2, ... (9 entities in total)
Functional Keywords	polycomb repressive complex, aebp2, jarid2, histone modification, gene regulation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	639134.12
Authors	Kasinath, V.,Faini, M.,Poepsel, S.,Reif, D.,Feng, A.,Stjepanovic, G.,Aebersold, R.,Nogales, E. (deposition date: 2018-01-06, release date: 2018-01-24, Last modification date: 2019-12-18)
Primary citation	Kasinath, V.,Faini, M.,Poepsel, S.,Reif, D.,Feng, X.A.,Stjepanovic, G.,Aebersold, R.,Nogales, E. Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359:940-944, 2018 Cited by PubMed: 29348366 DOI: 10.1126/science.aar5700 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation