6C24
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State
Summary for 6C24
Entry DOI | 10.2210/pdb6c24/pdb |
EMDB information | 7334 7335 |
Descriptor | Polycomb protein SUZ12, Protein Jumonji, Histone-lysine N-methyltransferase EZH2, ... (9 entities in total) |
Functional Keywords | polycomb repressive complex, aebp2, jarid2, histone modification, gene regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 639134.12 |
Authors | Kasinath, V.,Faini, M.,Poepsel, S.,Reif, D.,Feng, A.,Stjepanovic, G.,Aebersold, R.,Nogales, E. (deposition date: 2018-01-06, release date: 2018-01-24, Last modification date: 2019-12-18) |
Primary citation | Kasinath, V.,Faini, M.,Poepsel, S.,Reif, D.,Feng, X.A.,Stjepanovic, G.,Aebersold, R.,Nogales, E. Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359:940-944, 2018 Cited by PubMed: 29348366DOI: 10.1126/science.aar5700 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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