6C24
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, J (A, M, Q) | Polycomb protein SUZ12 | polymer | 739 | 83181.9 | 3 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 2 | B (B) | Protein Jumonji | polymer | 345 | 37706.4 | 1 | UniProt (Q92833) | Homo sapiens (Human) | Jumonji/ARID domain-containing protein 2 |
| 3 | C (E) | Protein Jumonji | polymer | 345 | 37664.4 | 1 | UniProt (Q92833) | Homo sapiens (Human) | Jumonji/ARID domain-containing protein 2 |
| 4 | D, L (K, C) | Histone-lysine N-methyltransferase EZH2 | polymer | 746 | 85492.3 | 2 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (Human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 5 | E (L) | Polycomb protein EED | polymer | 441 | 50267.7 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 6 | G (N) | Histone-binding protein RBBP4 | polymer | 425 | 47709.5 | 1 | UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) | Homo sapiens (Human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 7 | H (O) | JARID2-substrate | polymer | 7 | 735.9 | 1 | Homo sapiens | ||
| 8 | I (P) | Zinc finger protein AEBP2 | polymer | 295 | 33012.7 | 1 | UniProt (Q6ZN18) | Homo sapiens (Human) | Adipocyte enhancer-binding protein 2,AE-binding protein 2 |
| 9 | K (Z) | SUZ12 | polymer | 135 | 11507.2 | 1 | Homo sapiens |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 639134.1 | |
| All* | Total formula weight | 639134.1 |
