6C24

Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, M, Q	Polycomb protein SUZ12	polymer	739	83181.9	3	UniProt (Q15022) Pfam (PF09733) In PDB	Homo sapiens (Human)	Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog
2	B	Protein Jumonji	polymer	345	37706.4	1	UniProt (Q92833) In PDB	Homo sapiens (Human)	Jumonji/ARID domain-containing protein 2
3	E	Protein Jumonji	polymer	345	37664.4	1	UniProt (Q92833) In PDB	Homo sapiens (Human)	Jumonji/ARID domain-containing protein 2
4	K, C	Histone-lysine N-methyltransferase EZH2	polymer	746	85492.3	2	UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) In PDB	Homo sapiens (Human)	ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6
5	L	Polycomb protein EED	polymer	441	50267.7	1	UniProt (O75530) Pfam (PF00400) In PDB	Homo sapiens (Human)	hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1
6	N	Histone-binding protein RBBP4	polymer	425	47709.5	1	UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) In PDB	Homo sapiens (Human)	Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48
7	O	JARID2-substrate	polymer	7	735.9	1		Homo sapiens
8	P	Zinc finger protein AEBP2	polymer	295	33012.7	1	UniProt (Q6ZN18) In PDB	Homo sapiens (Human)	Adipocyte enhancer-binding protein 2,AE-binding protein 2
9	Z	SUZ12	polymer	135	11507.2	1		Homo sapiens

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	639134.1
All*	Total formula weight	639134.1

*Water molecules are not included.