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Crystal structure of Hepatitis C Virus E1 glycoprotein epitope 314-324 scaffold design 1W4K_08 in complex with neutralizing antibody F(ab) fragment IGH526
Descriptor:	1W4K_08, F(ab) IGH526
Authors:	Nagarathinam, K, Krey, T.
Deposit date:	2023-09-30
Release date:	2024-10-09
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	Crystal structure of Hepatitis C Virus E1 glycoprotein epitope 314-324 scaffold design 1W4K_08 in complex with neutralizing antibody F(ab) fragment IGH526 To Be Published

8QP7

Crystal structure of Hepatitis C Virus E2 glycoprotein epitopeI 411-424 scaffold design 4CIL_04
Descriptor:	Yop effector YopM,Internalin B
Authors:	Nagarathinam, K, Cramer, J.T, Krey, T.
Deposit date:	2023-09-30
Release date:	2024-10-09
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal structure of Hepatitis C Virus E2 glycoprotein epitopeI 411-424 scaffold design 4CIL_04 To Be Published

8BG8

SARS-CoV-2 S protein in complex with pT1696 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1696 Fab heavy chain, ...
Authors:	Hansen, G, Benecke, T, Vollmer, B, Gruenewald, K, Krey, T.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	ELECTRON MICROSCOPY (3.64 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG6

SARS-CoV-2 S protein in complex with pT1644 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1644 Fab heavy chain, ...
Authors:	Stroeh, L, Hansen, G, Vollmer, B, Krey, T, Benecke, T, Gruenewald, K.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	ELECTRON MICROSCOPY (4.11 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG1

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	X-RAY DIFFRACTION (2.88 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BEC

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1375 scFV
Descriptor:	SULFATE ION, Spike protein S1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:	2022-10-21
Release date:	2023-11-01
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG2

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1580 scFV
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1375 single-chain Fv
Authors:	Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG3

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1610 scFV
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1610 single-chain Fv
Authors:	Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG5

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1631 scFV
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1631 single-chain Fv
Authors:	Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

8BG4

Crystal structure of the SARS-CoV-2 S RBD in complex with pT1611 scFV
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, pT1611 single-chain Fv
Authors:	Hansen, G, Ssebyatika, G.L, Krey, T.
Deposit date:	2022-10-27
Release date:	2023-11-08
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published

7NXE

Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide
Descriptor:	Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15
Authors:	Ssebyatika, G, Krey, T.
Deposit date:	2021-03-18
Release date:	2021-06-09
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation. Plos Pathog., 17, 2021

5NPI

Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5
Descriptor:	Epitope peptide, Single chain variable fragment of the non-neutralizing antibody DAO5
Authors:	Vasiliauskaite, I, Rey, F.A, Krey, T.
Deposit date:	2017-04-16
Release date:	2017-05-24
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017

5NPJ

Structure of the Hepatitis C virus strain JFH1 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5
Descriptor:	Epitope peptide, Single chain variable fragment of the non-neutralizing antibody DAO5
Authors:	Vasiliauskaite, I, Rey, F.A, Krey, T.
Deposit date:	2017-04-16
Release date:	2017-05-24
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017

5NPH

Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5
Descriptor:	Genome polyprotein, Heavy chain of Fab fragment derived from non-neutralizing antibody DAO5, Light chain of Fab fragment derived from non-neutralizing antibody DAO5
Authors:	Vasiliauskaite, I, Rey, F.A, Krey, T.
Deposit date:	2017-04-16
Release date:	2017-05-24
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2. MBio, 8, 2017

5FGB

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.4
Descriptor:	Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, GLYCEROL, ...
Authors:	Girard-Blanc, C, Rey, F.A, Krey, T.
Deposit date:	2015-12-20
Release date:	2016-01-20
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. J.Virol., 90, 2016

5FGC

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.8
Descriptor:	Anti-HCV E2 Fab HC33.8 heavy chain, Anti-HCV E2 Fab HC33.8 light chain, Genome polyprotein
Authors:	Girard-Blanc, C, Rey, F.A, Krey, T.
Deposit date:	2015-12-20
Release date:	2016-01-20
Last modified:	2016-03-09
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. J.Virol., 90, 2016

6GFC

Structure of the BTB/POZ domain of human 90K
Descriptor:	Galectin-3-binding protein
Authors:	Ssebyatika, G, Krey, T.
Deposit date:	2018-04-29
Release date:	2018-05-09
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific. J. Virol., 92, 2018

6GFB

Structure of the BTB/POZ domain of human 90K
Descriptor:	Galectin-3-binding protein, ZINC ION
Authors:	Ssebyatika, G, Krey, T.
Deposit date:	2018-04-29
Release date:	2018-05-09
Last modified:	2018-07-11
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K Is Species Specific. J. Virol., 92, 2018

5MF1

Crystal structure of a C-terminally truncated trimeric ectodomain of the Chlamydomonas reinhardtii gamete fusion protein HAP2
Descriptor:	2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion protein HAP2/GCS1
Authors:	Fedry, J, Rey, F.A, Krey, T.
Deposit date:	2016-11-17
Release date:	2017-03-08
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein. Cell, 168, 2017

7NXP

Structure of the C-terminal domain of the pUL77 capsid protein from human cytomegalovirus (HCMV)
Descriptor:	Capsid vertex component 2, GLYCEROL
Authors:	Naniima, P, Legrand, P, Krey, T.
Deposit date:	2021-03-19
Release date:	2021-10-13
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.896 Å)
Cite:	Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021

7NXR

Structure of the C-terminal domain of the pORF19 capsid protein from murid gammaherpesvirus 68 (MuHV-68)
Descriptor:	Capsid vertex component 2
Authors:	Naniima, P, Legrand, P, Krey, T.
Deposit date:	2021-03-19
Release date:	2021-10-13
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021

7NXQ

Structure of the pentameric C-terminal domain of the capsid protein from Kaposi's sarcoma-associated herpesvirus (KSHV)
Descriptor:	ACETATE ION, Capsid vertex component 2
Authors:	Naniima, P, Legrand, P, Krey, T.
Deposit date:	2021-03-19
Release date:	2021-10-13
Last modified:	2024-06-19
Method:	X-RAY DIFFRACTION (2.422 Å)
Cite:	Assembly of infectious Kaposi's sarcoma-associated herpesvirus progeny requires formation of a pORF19 pentamer. Plos Biol., 19, 2021

5OW3

Crystal structure of a C-terminally truncated trimeric ectodomain of the Arabidopsis thaliana gamete fusion protein HAP2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ...
Authors:	Fedry, J, Legrand, P, Rey, F.A, Krey, T.
Deposit date:	2017-08-30
Release date:	2018-08-22
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.75 Å)
Cite:	Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes. PLoS Biol., 16, 2018

5OW4

Crystal structure of a protease-resistant fragment of the Trypanosoma cruzi gamete fusion protein HAP2 ectodomain
Descriptor:	Uncharacterized protein
Authors:	Fedry, J, Rey, F.A, Krey, T.
Deposit date:	2017-08-30
Release date:	2018-08-22
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes. PLoS Biol., 16, 2018

6VTW

De novo protein design enables the precise induction of RSV-neutralizing antibodies
Descriptor:	101F Fab Heavy Chain, 101F Fab Light Chain, S4_2.45
Authors:	Jardetzky, T, Correia, B.
Deposit date:	2020-02-13
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020

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