5FGB

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.4

Summary for 5FGB

• Entry DOI: 10.2210/pdb5fgb/pdb
• Descriptor: Anti-HCV E2 Fab HC84-1 light chain, Anti-HCV E2 Fab HC84-1 heavy chain, Genome polyprotein, ... (6 entities in total)
• Functional Keywords: fab fragment, neutralizing antibody, hepatitis c virus e2, immune system
• Biological source: Homo sapiens; More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958
• Total number of polymer chains: 6
• Total formula weight: 109430.48

Authors

Girard-Blanc, C.,Rey, F.A.,Krey, T. (deposition date: 2015-12-20, release date: 2016-01-20, Last modification date: 2024-01-10)

• Primary citation: Keck, Z.Y.,Girard-Blanc, C.,Wang, W.,Lau, P.,Zuiani, A.,Rey, F.A.,Krey, T.,Diamond, M.S.,Foung, S.K.; Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus.; J.Virol., 90:3112-3122, 2016; PubMed: 26739044; DOI: 10.1128/JVI.02458-15

Experimental method

X-RAY DIFFRACTION (1.65 Å)