8SP0
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![BU of 8sp0 by Molmil](/molmil-images/mine/8sp0) | Symmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid | Descriptor: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-01 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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8EE7
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8EEA
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![BU of 8eea by Molmil](/molmil-images/mine/8eea) | Structure of E.coli Septu (PtuAB) complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PtuA, PtuB | Authors: | Shen, Z.F, Fu, T.M. | Deposit date: | 2022-09-06 | Release date: | 2023-12-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense. Nat.Struct.Mol.Biol., 31, 2024
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8EE4
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![BU of 8ee4 by Molmil](/molmil-images/mine/8ee4) | Structure of PtuA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PtuA | Authors: | Shen, Z.F, Fu, T.M. | Deposit date: | 2022-09-06 | Release date: | 2024-01-03 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense. Nat.Struct.Mol.Biol., 31, 2024
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8SQU
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![BU of 8squ by Molmil](/molmil-images/mine/8squ) | Monomeric MapSPARTA bound with guide RNA and target DNA hybrid | Descriptor: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-04 | Release date: | 2023-08-23 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Oligomerization-mediated activation of a short prokaryotic Argonaute. Nature, 621, 2023
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8UAE
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![BU of 8uae by Molmil](/molmil-images/mine/8uae) | E. coli Sir2_HerA complex (12:6) with ATPgamaS | Descriptor: | MAGNESIUM ION, Nucleoside triphosphate hydrolase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-09-20 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8UAF
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![BU of 8uaf by Molmil](/molmil-images/mine/8uaf) | E. coli Sir2_HerA complex (12:6) bound with NAD+ | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-09-20 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8EFY
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8EFV
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8TJY
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![BU of 8tjy by Molmil](/molmil-images/mine/8tjy) | Structure of Gabija AB complex | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-24 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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8SXX
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![BU of 8sxx by Molmil](/molmil-images/mine/8sxx) | E. coli dodecamer SIR2 | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-05-24 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SUB
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![BU of 8sub by Molmil](/molmil-images/mine/8sub) | E. coli SIR2-HerA complex (dodecamer SIR2 pentamer HerA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... | Authors: | Shen, Z.F, Lin, Q.P, Fu, T.M. | Deposit date: | 2023-05-11 | Release date: | 2023-12-27 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
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8SUX
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![BU of 8sux by Molmil](/molmil-images/mine/8sux) | Structure of E. coli PtuA hexamer | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, PtuA | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-05-13 | Release date: | 2024-01-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense. Nat.Struct.Mol.Biol., 31, 2024
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8FEX
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8TK0
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![BU of 8tk0 by Molmil](/molmil-images/mine/8tk0) | Structure of Gabija AB complex | Descriptor: | Endonuclease GajA | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-24 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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8TK1
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![BU of 8tk1 by Molmil](/molmil-images/mine/8tk1) | Structure of Gabija AB complex 1 | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-25 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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7LF6
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![BU of 7lf6 by Molmil](/molmil-images/mine/7lf6) | Structure of lysosomal membrane protein | Descriptor: | Endosomal/lysosomal potassium channel TMEM175 | Authors: | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | Deposit date: | 2021-01-15 | Release date: | 2022-01-26 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Sci Adv, 8, 2022
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7U4T
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![BU of 7u4t by Molmil](/molmil-images/mine/7u4t) | Human V-ATPase in state 2 with SidK and mEAK-7 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, MTOR-associated protein MEAK7, ... | Authors: | Wang, L, Fu, T.M. | Deposit date: | 2022-03-01 | Release date: | 2022-08-24 | Last modified: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining. Proc.Natl.Acad.Sci.USA, 119, 2022
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8EHX
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![BU of 8ehx by Molmil](/molmil-images/mine/8ehx) | cryo-EM structure of TMEM63B in LMNG | Descriptor: | CSC1-like protein 2 | Authors: | Zheng, W, Fu, T.M, Holt, J.R. | Deposit date: | 2022-09-14 | Release date: | 2023-08-23 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron, 111, 2023
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8EHW
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6MJ2
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![BU of 6mj2 by Molmil](/molmil-images/mine/6mj2) | Human TRPM2 ion channel in a calcium- and ADPR-bound state | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (6.36 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MIX
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![BU of 6mix by Molmil](/molmil-images/mine/6mix) | Human TRPM2 ion channel in apo state | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MIZ
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6NDJ
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![BU of 6ndj by Molmil](/molmil-images/mine/6ndj) | Crystal structure of human NLRP6 PYD domain with MBP fusion | Descriptor: | Maltose/maltodextrin-binding periplasmic protein, NACHT, LRR and PYD domains-containing protein 6 chimera | Authors: | Shen, C, Fu, T.M, Wu, H. | Deposit date: | 2018-12-13 | Release date: | 2019-01-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6NCV
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![BU of 6ncv by Molmil](/molmil-images/mine/6ncv) | Cryo-EM structure of NLRP6 PYD filament | Descriptor: | NACHT, LRR and PYD domains-containing protein 6 | Authors: | Shen, C, Fu, T.M, Wu, H. | Deposit date: | 2018-12-12 | Release date: | 2019-01-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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