2PNU
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![BU of 2pnu by Molmil](/molmil-images/mine/2pnu) | Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744 | Descriptor: | (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Cantin, L, Faucher, F, Couture, J.F, Pereira de Jesus-Tran, K, Legrand, P, Ciobanu, C.L, Singh, S.M, Labrie, F, Breton, R. | Deposit date: | 2007-04-25 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12. J.Biol.Chem., 282, 2007
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1Q13
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![BU of 1q13 by Molmil](/molmil-images/mine/1q13) | Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION, ... | Authors: | Couture, J.-F, Cantin, L, Legrand, P, Luu-The, V, Labrie, F, Breton, R. | Deposit date: | 2003-07-18 | Release date: | 2004-11-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. J. Mol. Biol., 339, 2004
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3F9W
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![BU of 3f9w by Molmil](/molmil-images/mine/3f9w) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F9Y
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![BU of 3f9y by Molmil](/molmil-images/mine/3f9y) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F9X
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![BU of 3f9x by Molmil](/molmil-images/mine/3f9x) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me2 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3F9Z
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![BU of 3f9z by Molmil](/molmil-images/mine/3f9z) | Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy | Descriptor: | Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. | Deposit date: | 2008-11-14 | Release date: | 2008-11-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2Q8D
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![BU of 2q8d by Molmil](/molmil-images/mine/2q8d) | Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate | Descriptor: | HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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2Q8E
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![BU of 2q8e by Molmil](/molmil-images/mine/2q8e) | Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase | Descriptor: | JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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2Q8C
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![BU of 2q8c by Molmil](/molmil-images/mine/2q8c) | Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, HISTONE 3 PEPTIDE, JmjC domain-containing histone demethylation protein 3A, ... | Authors: | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | Deposit date: | 2007-06-10 | Release date: | 2007-07-03 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.047 Å) | Cite: | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat.Struct.Mol.Biol., 14, 2007
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4RIQ
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![BU of 4riq by Molmil](/molmil-images/mine/4riq) | |
4ETS
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![BU of 4ets by Molmil](/molmil-images/mine/4ets) | |
4X8P
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![BU of 4x8p by Molmil](/molmil-images/mine/4x8p) | Crystal structure of Ash2L SPRY domain in complex with RbBP5 | Descriptor: | GLYCEROL, Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2 | Authors: | Zhang, P, Chaturvedi, C.P, Brunzelle, J.S, Skiniotis, G, Brand, M, Shilatifard, A, Couture, J.-F. | Deposit date: | 2014-12-10 | Release date: | 2015-01-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Genes Dev., 29, 2015
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4X8N
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![BU of 4x8n by Molmil](/molmil-images/mine/4x8n) | Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5 | Descriptor: | Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2 | Authors: | Zhang, P, Chaturvedi, C.P, Brunzelle, J.S, Skiniotis, G, Brand, M, Shilatifard, A, Couture, J.-F. | Deposit date: | 2014-12-10 | Release date: | 2015-01-28 | Last modified: | 2020-01-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation. Genes Dev., 29, 2015
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3PSL
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![BU of 3psl by Molmil](/molmil-images/mine/3psl) | Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic | Descriptor: | N-alpha acetylated form of histone H3, WD repeat-containing protein 5 | Authors: | Avdic, V, Zhang, P, Lanouette, S, Voronova, A, Skerjanc, I, Couture, J.-F. | Deposit date: | 2010-12-01 | Release date: | 2010-12-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic. Faseb J., 25, 2011
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3S32
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![BU of 3s32 by Molmil](/molmil-images/mine/3s32) | Crystal structure of Ash2L N-terminal domain | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION | Authors: | Sarvan, S, Avdic, V, Tremblay, V, Chaturvedi, C.-P, Zhang, P, Lanouette, S, Blais, A, Brunzelle, J.S, Brand, M, Couture, J.-F. | Deposit date: | 2011-05-17 | Release date: | 2011-06-08 | Last modified: | 2012-01-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain. Nat.Struct.Mol.Biol., 18, 2011
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6MV7
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![BU of 6mv7 by Molmil](/molmil-images/mine/6mv7) | Crystal structure of RNAse 6 | Descriptor: | ADENOSINE MONOPHOSPHATE, Ribonuclease K6 | Authors: | Couture, J.-F, Doucet, N. | Deposit date: | 2018-10-24 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding. Biochemistry, 59, 2020
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6MV6
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![BU of 6mv6 by Molmil](/molmil-images/mine/6mv6) | Crystal structure of RNAse 6 | Descriptor: | PHOSPHATE ION, Ribonuclease K6 | Authors: | Couture, J.-F, Doucet, N. | Deposit date: | 2018-10-24 | Release date: | 2019-11-13 | Last modified: | 2020-05-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding. Biochemistry, 59, 2020
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3M53
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![BU of 3m53 by Molmil](/molmil-images/mine/3m53) | SET7/9 in complex with TAF10 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M55
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![BU of 3m55 by Molmil](/molmil-images/mine/3m55) | SET7/9 Y305F in complex with TAF10-K189me1 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M58
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![BU of 3m58 by Molmil](/molmil-images/mine/3m58) | SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M5A
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![BU of 3m5a by Molmil](/molmil-images/mine/3m5a) | SET7/9 Y245A in complex with TAF10-K189me3 peptide and AdoHcy | Descriptor: | COBALT (II) ION, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M59
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![BU of 3m59 by Molmil](/molmil-images/mine/3m59) | SET7/9 Y245A in complex with TAF10-K189me2 peptide and AdoHcy | Descriptor: | COBALT (II) ION, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M54
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![BU of 3m54 by Molmil](/molmil-images/mine/3m54) | SET7/9 Y305F in complex with TAF10 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M56
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![BU of 3m56 by Molmil](/molmil-images/mine/3m56) | SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10-K189me2 PEPTIDE | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M57
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![BU of 3m57 by Molmil](/molmil-images/mine/3m57) | SET7/9 Y245A in complex with TAF10 peptide and AdoHcy | Descriptor: | GLYCEROL, Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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