1TTL
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![BU of 1ttl by Molmil](/molmil-images/mine/1ttl) | Omega-conotoxin GVIA, a N-type calcium channel blocker | Descriptor: | Omega-conotoxin GVIA | Authors: | Mould, J, Yasuda, T, Schroeder, C.I, Beedle, A.M, Doering, C.J, Zamponi, G.W, Adams, D.J, Lewis, R.J. | Deposit date: | 2004-06-23 | Release date: | 2004-07-13 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels J.Biol.Chem., 279, 2004
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1U4B
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![BU of 1u4b by Molmil](/molmil-images/mine/1u4b) | Extension of an adenine-8oxoguanine mismatch | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1UA0
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![BU of 1ua0 by Molmil](/molmil-images/mine/1ua0) | Aminofluorene DNA adduct at the pre-insertion site of a DNA polymerase | Descriptor: | 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... | Authors: | Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. | Deposit date: | 2004-08-11 | Release date: | 2004-09-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
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1TR6
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![BU of 1tr6 by Molmil](/molmil-images/mine/1tr6) | NMR solution structure of omega-conotoxin [K10]GVIA, a cyclic cysteine knot peptide | Descriptor: | Omega-conotoxin GVIA | Authors: | Mould, J, Yasuda, T, Schroeder, C.I, Beedle, A.M, Doering, C.J, Zamponi, G.W, Adams, D.J, Lewis, R.J. | Deposit date: | 2004-06-21 | Release date: | 2004-07-13 | Last modified: | 2011-10-05 | Method: | SOLUTION NMR | Cite: | The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels J.Biol.Chem., 279, 2004
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1UA1
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![BU of 1ua1 by Molmil](/molmil-images/mine/1ua1) | Structure of aminofluorene adduct paired opposite cytosine at the polymerase active site. | Descriptor: | 2-AMINOFLUORENE, DNA polymerase I, DNA primer strand, ... | Authors: | Hsu, G.W, Kiefer, J.R, Becherel, O.J, Fuchs, R.P.P, Beese, L.S. | Deposit date: | 2004-08-11 | Release date: | 2004-09-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase J.Biol.Chem., 279, 2004
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1U47
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![BU of 1u47 by Molmil](/molmil-images/mine/1u47) | cytosine-8-Oxoguanine base pair at the polymerase active site | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1R75
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![BU of 1r75 by Molmil](/molmil-images/mine/1r75) | |
1TPT
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![BU of 1tpt by Molmil](/molmil-images/mine/1tpt) | THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION | Descriptor: | SULFATE ION, THYMIDINE PHOSPHORYLASE, THYMINE | Authors: | Walter, M.R, Cook, W.J, Cole, L.B, Short, S.A, Koszalka, G.W, Krenitsky, T.A, Ealick, S.E. | Deposit date: | 1990-06-14 | Release date: | 1991-07-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution. J.Biol.Chem., 265, 1990
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1SSV
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![BU of 1ssv by Molmil](/molmil-images/mine/1ssv) | Compensating bends in a 16 base-pair DNA oligomer containing a T3A3 segment | Descriptor: | 5'-D(*CP*GP*AP*GP*GP*TP*TP*TP*AP*AP*AP*CP*CP*TP*CP*G)-3' | Authors: | McAteer, K, Aceves-Gaona, A, Michalczyk, R, Buchko, G.W, Isern, N.G, Silks, L.A, Miller, J.H, Kennedy, M.A. | Deposit date: | 2004-03-24 | Release date: | 2004-12-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Compensating bends in a 16-base-pair DNA oligomer containing a T(3)A(3) segment: A NMR study of global DNA curvature Biopolymers, 75, 2004
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1SS7
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![BU of 1ss7 by Molmil](/molmil-images/mine/1ss7) | Compensating bends in a 16 base-pair DNA oligomer containing a T3A3 segment | Descriptor: | 5'-D(*CP*GP*AP*GP*GP*TP*TP*TP*AP*AP*AP*CP*CP*TP*CP*G)-3' | Authors: | McAteer, K, Aceves-Gaona, A, Michalczyk, R, Buchko, G.W, Isern, N.G, Silks, L.A, Miller, J.H, Kennedy, M.A. | Deposit date: | 2004-03-23 | Release date: | 2004-12-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Compensating bends in a 16-base-pair DNA oligomer containing a T(3)A(3) segment: A NMR study of global DNA curvature Biopolymers, 75, 2004
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1U49
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![BU of 1u49 by Molmil](/molmil-images/mine/1u49) | Adenine-8oxoguanine mismatch at the polymerase active site | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1U48
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![BU of 1u48 by Molmil](/molmil-images/mine/1u48) | Extension of a cytosine-8-oxoguanine base pair | Descriptor: | DNA polymerase I, DNA primer strand, DNA template strand with 8-oxoguanine, ... | Authors: | Hsu, G.W, Ober, M, Carell, T, Beese, L.S. | Deposit date: | 2004-07-23 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature, 431, 2004
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1VJ6
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![BU of 1vj6 by Molmil](/molmil-images/mine/1vj6) | |
4PXZ
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![BU of 4pxz by Molmil](/molmil-images/mine/4pxz) | Crystal structure of P2Y12 receptor in complex with 2MeSADP | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), CHOLESTEROL, ... | Authors: | Zhang, J, Zhang, K, Gao, Z.G, Paoletta, S, Zhang, D, Han, G.W, Li, T, Ma, L, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR) | Deposit date: | 2014-03-25 | Release date: | 2014-04-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Agonist-bound structure of the human P2Y12 receptor Nature, 509, 2014
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4QIM
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![BU of 4qim by Molmil](/molmil-images/mine/4qim) | Structure of the human smoothened receptor in complex with ANTA XV | Descriptor: | 2-{6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol, Smoothened homolog/Soluble cytochrome b562 chimeric protein, ZINC ION | Authors: | Wang, C, Wu, H, Evron, T, Vardy, E, Han, G.W, Huang, X.-P, Hufeisen, S.J, Mangano, T.J, Urban, D.J, Katritch, V, Cherezov, V, Caron, M.G, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2014-05-31 | Release date: | 2014-07-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5, 2014
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4QIN
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![BU of 4qin by Molmil](/molmil-images/mine/4qin) | Structure of the human smoothened receptor in complex with SAG1.5 | Descriptor: | 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide, Smoothened homolog/Soluble cytochrome b562 chimeric protein | Authors: | Wang, C, Wu, H, Evron, T, Vardy, E, Han, G.W, Huang, X.-P, Hufeisen, S.J, Mangano, T.J, Urban, D.J, Katritch, V, Cherezov, V, Caron, M.G, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2014-05-31 | Release date: | 2014-07-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun, 5, 2014
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4QYY
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![BU of 4qyy by Molmil](/molmil-images/mine/4qyy) | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | Descriptor: | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. | Deposit date: | 2014-07-26 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
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4R45
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![BU of 4r45 by Molmil](/molmil-images/mine/4r45) | Racemic crystal structure of a bimolecular DNA G-quadruplex (P-1) | Descriptor: | 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R4A
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![BU of 4r4a by Molmil](/molmil-images/mine/4r4a) | Racemic crystal structure of a cobalt-bound B-DNA duplex | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', COBALT (II) ION, SPERMINE | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R49
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![BU of 4r49 by Molmil](/molmil-images/mine/4r49) | Racemic crystal structure of a calcium-bound B-DNA duplex | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', CALCIUM ION, SODIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R48
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![BU of 4r48 by Molmil](/molmil-images/mine/4r48) | Racemic crystal structure of a calcium-bound DNA four-way junction | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', CALCIUM ION, SODIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R4D
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![BU of 4r4d by Molmil](/molmil-images/mine/4r4d) | Racemic crystal structure of a magnesium-bound B-DNA duplex | Descriptor: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3', MAGNESIUM ION, SODIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4QZV
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![BU of 4qzv by Molmil](/molmil-images/mine/4qzv) | Bat-derived coronavirus HKU4 uses MERS-CoV receptor human CD26 for cell entry | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | Authors: | Gao, F.G, Wang, Q.H, Qi, J.X, Lu, G.W. | Deposit date: | 2014-07-29 | Release date: | 2014-10-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.592 Å) | Cite: | Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26. Cell Host Microbe, 16, 2014
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4R47
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![BU of 4r47 by Molmil](/molmil-images/mine/4r47) | Racemic crystal structure of a bimolecular DNA G-quadruplex (P21/n) | Descriptor: | 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', MAGNESIUM ION, POTASSIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R44
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![BU of 4r44 by Molmil](/molmil-images/mine/4r44) | Racemic crystal structure of a tetramolecular DNA G-quadruplex | Descriptor: | 5'-D(*TP*GP*GP*GP*GP*T)-3', POTASSIUM ION, SODIUM ION | Authors: | Mandal, P.K, Collie, G.W, Kauffmann, B, Huc, I. | Deposit date: | 2014-08-19 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.695 Å) | Cite: | Racemic DNA crystallography. Angew.Chem.Int.Ed.Engl., 53, 2014
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