1TTL

Omega-conotoxin GVIA, a N-type calcium channel blocker

Summary for 1TTL

Related2CCO 1OMC
DescriptorOmega-conotoxin GVIA (1 entity in total)
Functional Keywordsdisulfide rich, four loop framework, amidated c-terminal, toxin
Biological sourceConus geographus (geography cone)
Cellular locationSecreted P01522
Total number of polymer chains1
Total molecular weight3046.42
Authors
Mould, J.,Yasuda, T.,Schroeder, C.I.,Beedle, A.M.,Doering, C.J.,Zamponi, G.W.,Adams, D.J.,Lewis, R.J. (deposition date: 2004-06-23, release date: 2004-07-13, Last modification date: 2011-07-13)
Primary citation
Mould, J.,Yasuda, T.,Schroeder, C.I.,Beedle, A.M.,Doering, C.J.,Zamponi, G.W.,Adams, D.J.,Lewis, R.J.
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels
J.Biol.Chem., 279:34705-34714, 2004
PubMed: 15166237 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M310848200
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers95.4%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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