5J9K
 
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) in complex with rice D53 repressor EAR peptide motif | | Descriptor: | Protein TPR1, ZINC ION, rice D53 peptide 794-808 | | Authors: | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | Deposit date: | 2016-04-10 | | Release date: | 2017-07-05 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
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5JA5
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A and L130A mutant in complex with rice D53 repressor EAR peptide motif | | Descriptor: | Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION | | Authors: | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | Deposit date: | 2016-04-12 | | Release date: | 2017-07-05 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
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5JGC
 | | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A, L130A, L179A and I195A mutant | | Descriptor: | Protein TPR1, ZINC ION | | Authors: | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | | Deposit date: | 2016-04-20 | | Release date: | 2017-07-05 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
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4RDD
 | | Co-crystal structure of SHP2 in complex with a Cefsulodin derivative | | Descriptor: | 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyr idinium, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. | | Deposit date: | 2014-09-18 | | Release date: | 2015-07-01 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (1.601 Å) | | Cite: | Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett, 6, 2015
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7KLZ
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8GYB
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8GYA
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8GY4
 | | Crystal structure of Alongshan virus methyltransferase | | Descriptor: | Methyltransferase | | Authors: | Chen, H, Lin, S, Lu, G.W. | | Deposit date: | 2022-09-21 | | Release date: | 2023-09-27 | | Last modified: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
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8GY9
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8ZF0
 | | pRib-ADP bound OsEDS1-PAD4-ADR1 complex | | Descriptor: | EDS1, Lipase-like PAD4, RPW8 domain-containing protein, ... | | Authors: | Xu, W.Y, Zhang, Y. | | Deposit date: | 2024-05-07 | | Release date: | 2024-11-13 | | Last modified: | 2025-01-01 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | A canonical protein complex controls immune homeostasis and multipathogen resistance.
Science, 386, 2024
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9JS4
 | | Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD | | Descriptor: | Heavy chain of 8G3, Light chain of 8G3, Spike glycoprotein | | Authors: | Li, J, Li, H. | | Deposit date: | 2024-09-30 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8WJH
 | | Cryo-EM structure of OAT4 | | Descriptor: | CHLORIDE ION, Solute carrier family 22 member 11 | | Authors: | Qian, H.W, He, J.J. | | Deposit date: | 2023-09-26 | | Release date: | 2024-08-28 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for the transport and substrate selection of human urate transporter 1.
Cell Rep, 43, 2024
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8WJG
 | | Cryo-EM structure of URAT1(R477S) | | Descriptor: | Solute carrier family 22 member 12 | | Authors: | Qian, H.W, He, J.J. | | Deposit date: | 2023-09-25 | | Release date: | 2024-08-28 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for the transport and substrate selection of human urate transporter 1.
Cell Rep, 43, 2024
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8WJQ
 | | Cryo-EM structure of URAT1(R477S)-Urate complex | | Descriptor: | Solute carrier family 22 member 12, URIC ACID | | Authors: | Qian, H.W, He, J.J. | | Deposit date: | 2023-09-26 | | Release date: | 2024-08-28 | | Last modified: | 2025-07-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis for the transport and substrate selection of human urate transporter 1.
Cell Rep, 43, 2024
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3NTU
 | | RADA RECOMBINASE D302K MUTANT IN COMPLEX with AMP-PNP | | Descriptor: | DNA repair and recombination protein radA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Luo, Y. | | Deposit date: | 2010-07-05 | | Release date: | 2011-07-27 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | RAD51 protein ATP cap regulates nucleoprotein filament stability.
J.Biol.Chem., 287, 2012
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3FV8
 | | JNK3 bound to piperazine amide inhibitor, SR2774. | | Descriptor: | 1,2-ETHANEDIOL, 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide, Mitogen-activated protein kinase 10 | | Authors: | Habel, J.E. | | Deposit date: | 2009-01-15 | | Release date: | 2009-04-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
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6BD4
 | | Crystal structure of human apo-Frizzled4 receptor | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Frizzled-4/Rubredoxin chimeric protein, OLEIC ACID, ... | | Authors: | Yang, S, Wu, Y, Pu, M, Chen, Y, Dong, S, Guo, Y, Han, G.Y, Stevens, R.C, Zhao, S, Xu, F. | | Deposit date: | 2017-10-21 | | Release date: | 2018-08-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
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8ENZ
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8ENX
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8ENY
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8EO0
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8ENS
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8ENW
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4N9K
 | | crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine | | Descriptor: | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase | | Authors: | Pan, X, Wong, W, Zhao, Y. | | Deposit date: | 2013-10-21 | | Release date: | 2014-09-10 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
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4N9L
 | | crystal structure of beta-lactamse PenP_E166S in complex with meropenem | | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase | | Authors: | Pan, X, Wong, W, Zhao, Y. | | Deposit date: | 2013-10-21 | | Release date: | 2014-09-10 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53, 2014
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