4R5Y
 
 | | The complex structure of Braf V600E kinase domain with a novel Braf inhibitor | | Descriptor: | 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one, Serine/threonine-protein kinase B-raf | | Authors: | Feng, Y, Peng, H, Zhang, Y, Liu, Y, Wei, M. | | Deposit date: | 2014-08-22 | | Release date: | 2016-02-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
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4IH1
 | | Crystal structure of Karrikin Insensitive 2 (KAI2) from Arabidopsis thaliana | | Descriptor: | Hydrolase, alpha/beta fold family protein | | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | | Deposit date: | 2012-12-18 | | Release date: | 2013-01-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
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4IH9
 | | Crystal structure of rice DWARF14 (D14) | | Descriptor: | Dwarf 88 esterase | | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | | Deposit date: | 2012-12-18 | | Release date: | 2013-01-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
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5DJ5
 | | Crystal structure of rice DWARF14 in complex with synthetic strigolactone GR24 | | Descriptor: | (3E,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methylidene)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one, Probable strigolactone esterase D14 | | Authors: | Zhou, X.E, Zhao, L.-H, Yi, W, Wu, Z.-S, Liu, Y, Kang, Y, Hou, L, de Waal, P.W, Li, S, Jiang, Y, Melcher, K, Xu, H.E. | | Deposit date: | 2015-09-01 | | Release date: | 2015-10-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3.
Cell Res., 25, 2015
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4IHA
 | | Crystal structure of rice DWARF14 (D14) in complex with a GR24 hydrolysis intermediate | | Descriptor: | (2R,3R)-2,4,4-trihydroxy-3-methylbutanal, Dwarf 88 esterase | | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | | Deposit date: | 2012-12-18 | | Release date: | 2013-01-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
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4IH4
 | | Crystal structure of Arabidopsis DWARF14 orthologue, AtD14 | | Descriptor: | AT3g03990/T11I18_10 | | Authors: | Zhou, X.E, Zhao, L.-H, Wu, Z.-S, Yi, W, Li, S, Li, Y, Xu, Y, Xu, T.-H, Liu, Y, Chen, R.-Z, Kovach, A, Kang, Y, Hou, L, He, Y, Zhang, C, Melcher, K, Xu, H.E. | | Deposit date: | 2012-12-18 | | Release date: | 2013-01-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
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6VZU
 | | TTLL6 bound to alpha-elongation analog | | Descriptor: | (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid, (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mahalingan, K.K, Keenen, E.K, Strickland, M, Li, Y, Liu, Y, Ball, H.B, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2020-02-28 | | Release date: | 2020-08-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Nat.Struct.Mol.Biol., 27, 2020
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6VZQ
 | | Engineered TTLL6 mutant bound to alpha-elongation analog | | Descriptor: | (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, (2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mahalingan, K.K, Keenen, E.K, Strickland, E.K, Li, Y, Liu, Y, Ball, H.L, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2020-02-28 | | Release date: | 2020-08-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Nat.Struct.Mol.Biol., 27, 2020
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6VZT
 | | TTLL6 bound to ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Mahalingan, K.K, Keenen, E.K, Strickland, M, Li, Y, Liu, Y, Ball, H.L, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2020-02-28 | | Release date: | 2020-08-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Nat.Struct.Mol.Biol., 27, 2020
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6VZV
 | | TTLL6 bound to gamma-elongation analog | | Descriptor: | (2~{S})-2-[[[(3~{R})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, (2~{S})-2-[[[(3~{S})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mahalingan, K.K, Keenen, E.K, Strickland, M, Li, Y, Liu, Y, Ball, H.L, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2020-02-28 | | Release date: | 2020-08-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Nat.Struct.Mol.Biol., 27, 2020
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6VZR
 | | Engineered TTLL6 bound to the initiation analog | | Descriptor: | (2~{S})-2-[[[(3~{R})-3-acetamido-4-(ethylamino)-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Mahalingan, K.K, Keenen, E.K, Strickland, M, Li, Y, Liu, Y, Ball, H.L, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | | Deposit date: | 2020-02-28 | | Release date: | 2020-08-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Nat.Struct.Mol.Biol., 27, 2020
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8TJP
 | | KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner | | Descriptor: | EryAII | | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | | Deposit date: | 2023-07-23 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis
To Be Published
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3EBJ
 | | Crystal structure of an avian influenza virus protein | | Descriptor: | MAGNESIUM ION, Polymerase acidic protein | | Authors: | Yuan, P, Bartlam, M, Lou, Z, Chen, S, Rao, Z, Liu, Y. | | Deposit date: | 2008-08-27 | | Release date: | 2009-02-10 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
Nature, 458, 2009
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8TJO
 | | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked Intra-State 1 | | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | | Deposit date: | 2023-07-23 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.61 Å) | | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis
To Be Published
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3ERW
 | | Crystal Structure of StoA from Bacillus subtilis | | Descriptor: | Sporulation thiol-disulfide oxidoreductase A | | Authors: | Crow, A, Liu, Y, Moller, M.C, Le Brun, N.E, Hederstedt, L. | | Deposit date: | 2008-10-03 | | Release date: | 2009-01-20 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure and Functional Properties of Bacillus subtilis Endospore Biogenesis Factor StoA
J.Biol.Chem., 284, 2009
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8TJN
 | | Crosslinked 6-deoxyerythronolide B synthase (DEBS) Module 1 in complex with antibody fragment 1B2: Crosslinked State 1 | | Descriptor: | Antibody Fragment 1B2, Heavy Chain, Light Chain, ... | | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | | Deposit date: | 2023-07-23 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.73 Å) | | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis
To Be Published
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8TGZ
 | | CryoEM structure of neutralizing antibody HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HC84.26 Heavy chain, ... | | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-07-13 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | CryoEM structure of neutralizing antibody HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2
To Be Published
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8THZ
 | | CryoEM structure of neutralizing antibodies CBH-7 and HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CBH-7 Heavy chain, ... | | Authors: | Shahid, S, Jiang, L, Liu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-07-18 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | CryoEM structure of neutralizing antibodies CBH-7 and HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2
To Be Published
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8TGV
 | | CryoEM structure of Fab HC84.26-HCV E2 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HC84.26 Heavy chain, ... | | Authors: | Shahid, S, Liqun, J, LIu, Y, Hasan, S.S, Mariuzza, R.A. | | Deposit date: | 2023-07-13 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | CryoEM structure of Fab HC84.26-HCV E2 complex
To Be Published
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1T1J
 | | Crystal structure of genomics APC5043 | | Descriptor: | hypothetical protein | | Authors: | Dong, A, Xu, X, Liu, Y, Zhang, R, Savchenko, A, Edwards, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2004-04-16 | | Release date: | 2004-08-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structure of Conserved Hypothetical Protein PA1492 from Pseudomonas aeruginosa
TO BE PUBLISHED
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5D87
 | | Staphyloferrin B precursor biosynthetic enzyme SbnA Y152F/S185G variant | | Descriptor: | MAGNESIUM ION, POTASSIUM ION, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Kobylarz, M.J, Grigg, J.C, Liu, Y, Lee, M.S.F, Heinrichs, D.E, Murphy, M.E.P. | | Deposit date: | 2015-08-15 | | Release date: | 2016-02-03 | | Last modified: | 2020-01-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.
Biochemistry, 55, 2016
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5D85
 | | Staphyloferrin B precursor biosynthetic enzyme SbnA bound to aminoacrylate intermediate | | Descriptor: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CITRATE ANION, GLYCEROL, ... | | Authors: | Kobylarz, M.J, Grigg, J.C, Liu, Y, Lee, M.S.F, Heinrichs, D.E, Murphy, M.E.P. | | Deposit date: | 2015-08-15 | | Release date: | 2016-02-03 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.
Biochemistry, 55, 2016
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5D86
 | | Staphyloferrin B precursor biosynthetic enzyme SbnA Y152F variant | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Kobylarz, M.J, Grigg, J.C, Liu, Y, Lee, M.S.F, Heinrichs, D.E, Murphy, M.E.P. | | Deposit date: | 2015-08-15 | | Release date: | 2016-02-03 | | Last modified: | 2020-01-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.
Biochemistry, 55, 2016
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8I3X
 | | Rice APIP6-RING homodimer | | Descriptor: | RING-type domain-containing protein, ZINC ION | | Authors: | Zheng, Y, Zhang, X, Liu, Y, Liu, J, Wang, D. | | Deposit date: | 2023-01-18 | | Release date: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Crystal structure of rice APIP6 reveals a new dimerization mode of RING-type E3 ligases that facilities the construction of its working model
Phytopathol Res, 5, 2023
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6R47
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