6VZQ

Engineered TTLL6 mutant bound to alpha-elongation analog

Summary for 6VZQ

Entry DOI	10.2210/pdb6vzq/pdb
Descriptor	Tubulin polyglutamylase TTLL6, ADENOSINE-5'-DIPHOSPHATE, (2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ... (7 entities in total)
Functional Keywords	protein engineering, ttll6, amino acid ligase, glutamylation, ligase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	218617.46
Authors	Mahalingan, K.K.,Keenen, E.K.,Strickland, E.K.,Li, Y.,Liu, Y.,Ball, H.L.,Tanner, M.E.,Tjandra, N.,Roll-Mecak, A. (deposition date: 2020-02-28, release date: 2020-08-12, Last modification date: 2023-10-11)
Primary citation	Mahalingan, K.K.,Keith Keenan, E.,Strickland, M.,Li, Y.,Liu, Y.,Ball, H.L.,Tanner, M.E.,Tjandra, N.,Roll-Mecak, A. Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Nat.Struct.Mol.Biol., 27:802-813, 2020 Cited by PubMed: 32747782 DOI: 10.1038/s41594-020-0462-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.08 Å)

Structure validation