6VZQ
Engineered TTLL6 mutant bound to alpha-elongation analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tubulin polyglutamylase TTLL6 | polymer | 453 | 53345.4 | 4 | UniProt (A4Q9E8) Pfam (PF03133) | Mus musculus (Mouse) | Tubulin--tyrosine ligase-like protein 6 |
| 2 | E, I, T, Y (A, B, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 3 | F (A) | (2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid | non-polymer | 375.2 | 1 | Chemie (RZY) | |||
| 4 | AA, BA, G, H, M... (D, A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 5 | CA, DA, EA, FA, GA... (D, B, C) | GLYCEROL | non-polymer | 92.1 | 18 | Chemie (GOL) | |||
| 6 | L, U, Z (B, C, D) | (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid | non-polymer | 433.2 | 3 | Chemie (RZP) | |||
| 7 | MA, NA, OA, PA (A, B, C, D) | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 51 - 503 (UniProt: A4Q9E8)
| PDB | External Database | Details |
|---|---|---|
| Ala 179 | Cys 179 | engineered mutation |
| Arg 180 | Gln 180 | engineered mutation |
| Ile 362 | His 362 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 213381.6 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 5235.9 | |
| All* | Total formula weight | 218617.5 |
