6VZQ

Engineered TTLL6 mutant bound to alpha-elongation analog

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tubulin polyglutamylase TTLL6	polymer	453	53345.4	4	UniProt (A4Q9E8) Pfam (PF03133) In PDB	Mus musculus (Mouse)	Tubulin--tyrosine ligase-like protein 6
2	A, B, C, D	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	4	Chemie (ADP)
3	A	(2~{S})-2-[[[(1~{S})-1-acetamidoethyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid	non-polymer		375.2	1	Chemie (RZY)
4	D, A, B, C	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
5	D, B, C	GLYCEROL	non-polymer		92.1	18	Chemie (GOL)
6	B, C, D	(2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid	non-polymer		433.2	3	Chemie (RZP)
7		water	water		18.0	96	Chemie (HOH)

Sequence modifications

A, B, C, D: 51 - 503 (UniProt: A4Q9E8)

PDB	External Database	Details
Ala 179	Cys 179	engineered mutation
Arg 180	Gln 180	engineered mutation
Ile 362	His 362	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	213381.6
Non-Polymers*	Number of molecules	34
	Total formula weight	5235.9
All*	Total formula weight	218617.5

*Water molecules are not included.