6VZR

Engineered TTLL6 bound to the initiation analog

Summary for 6VZR

Entry DOI	10.2210/pdb6vzr/pdb
Descriptor	Tubulin polyglutamylase TTLL6, TTLL6 unregistered chain, (2~{S})-2-[[[(3~{R})-3-acetamido-4-(ethylamino)-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ... (8 entities in total)
Functional Keywords	ttll6, protein engineering, glutamylation, phosphinic acid based inhibitor, ligase
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	6
Total formula weight	221513.96
Authors	Mahalingan, K.K.,Keenen, E.K.,Strickland, M.,Li, Y.,Liu, Y.,Ball, H.L.,Tanner, M.E.,Tjandra, N.,Roll-Mecak, A. (deposition date: 2020-02-28, release date: 2020-08-12, Last modification date: 2023-10-11)
Primary citation	Mahalingan, K.K.,Keith Keenan, E.,Strickland, M.,Li, Y.,Liu, Y.,Ball, H.L.,Tanner, M.E.,Tjandra, N.,Roll-Mecak, A. Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Nat.Struct.Mol.Biol., 27:802-813, 2020 Cited by PubMed: 32747782 DOI: 10.1038/s41594-020-0462-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation