6K4Y
 
 | | CryoEM structure of sigma appropriation complex | | Descriptor: | 10 kDa anti-sigma factor, DNA (60-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Shi, J, Wen, A, Feng, Y. | | Deposit date: | 2019-05-27 | | Release date: | 2019-08-07 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structural basis of sigma appropriation.
Nucleic Acids Res., 47, 2019
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8SUF
 | | The complex of TOL-1 ectodomain bound to LAT-1 Lectin domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Latrophilin-like protein 1, ... | | Authors: | Carmona Rosas, G, Li, J, Arac, D, Ozkan, E. | | Deposit date: | 2023-05-12 | | Release date: | 2024-05-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Structural basis and functional roles for Toll-like receptor binding to Latrophilin adhesion-GPCR in embryo development
To Be Published
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7XYB
 | | The cryo-EM structure of an AlpA-loaded complex | | Descriptor: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wen, A, Feng, Y. | | Deposit date: | 2022-06-01 | | Release date: | 2022-07-20 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022
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7XYA
 | | The cryo-EM structure of an AlpA-loading complex | | Descriptor: | AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Wen, A, Feng, Y. | | Deposit date: | 2022-06-01 | | Release date: | 2022-07-20 | | Last modified: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of AlpA-dependent transcription antitermination.
Nucleic Acids Res., 50, 2022
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7WBI
 | | BF2*1901-FLU | | Descriptor: | Beta-2-microglobulin, ILE-ARG-HIS-GLU-ASN-ARG-MET-VAL-LEU, MHC class I alpha chain 2 | | Authors: | Liu, W.J. | | Deposit date: | 2021-12-16 | | Release date: | 2022-12-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease.
J Immunol., 210, 2023
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7WBG
 | | BF2*1901/RY8 | | Descriptor: | ARG-ARG-ARG-GLU-GLN-THR-ASP-TYR, Beta-2-microglobulin, MHC class I alpha chain 2 | | Authors: | Liu, W.J. | | Deposit date: | 2021-12-16 | | Release date: | 2022-12-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease.
J Immunol., 210, 2023
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6M6C
 | | CryoEM structure of Thermus thermophilus RNA polymerase elongation complex | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Shi, J, Wen, A, Feng, Y. | | Deposit date: | 2020-03-14 | | Release date: | 2020-10-14 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of Mfd-dependent transcription termination.
Nucleic Acids Res., 48, 2020
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6A2H
 | | Architectural roles of Cren7 in folding crenarchaeal chromatin filament | | Descriptor: | Chromatin protein Cren7, DNA (5'-D(P*AP*AP*TP*TP*AP*C)-3'), DNA (5'-D(P*GP*TP*AP*AP*TP*T)-3') | | Authors: | Zhang, Z.F, Zhao, M.H, Chen, Y.Y, Wang, L, Dong, Y.H, Gong, Y, Huang, L. | | Deposit date: | 2018-06-11 | | Release date: | 2019-01-16 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Architectural roles of Cren7 in folding crenarchaeal chromatin filament.
Mol. Microbiol., 111, 2019
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6A2I
 | | Architectural roles of Cren7 in folding crenarchaeal chromatin filament | | Descriptor: | Chromatin protein Cren7, DNA (5'-D(*CP*GP*TP*AP*GP*CP*TP*AP*AP*TP*TP*AP*GP*CP*TP*AP*CP*G)-3') | | Authors: | Zhang, Z.F, Zhao, M.H, Chen, Y.Y, Wang, L, Dong, Y.H, Gong, Y, Huang, L. | | Deposit date: | 2018-06-11 | | Release date: | 2019-01-16 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Architectural roles of Cren7 in folding crenarchaeal chromatin filament.
Mol. Microbiol., 111, 2019
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3OV8
 | | Crystal structure of AF1382 from Archaeoglobus fulgidus, High resolution | | Descriptor: | ACETATE ION, CHLORIDE ION, Protein AF_1382 | | Authors: | Zhu, J.-Y, Zhao, M, Fu, Z.-Q, Yang, H, Chang, J, Hao, X, Chen, L, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2010-09-16 | | Release date: | 2011-11-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8501 Å) | | Cite: | Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal.
Acta Crystallogr.,Sect.D, 68, 2012
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1Q4V
 | | CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR | | Descriptor: | Insulin, PHENOL, ZINC ION | | Authors: | Wan, Z.L, Xu, B, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. | | Deposit date: | 2003-08-04 | | Release date: | 2003-08-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the
mechanism of receptor binding.
Biochemistry, 42, 2003
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8F1G
 | | Crystal structure of human WDR5 in complex with compound WM662 | | Descriptor: | (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... | | Authors: | Liu, H. | | Deposit date: | 2022-11-05 | | Release date: | 2023-01-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
Acs Chem.Biol., 18, 2023
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5JYY
 | | Structure-based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-resistant Influenza Viruses | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-[(2-methoxyethyl)carbamoyl]-D-glycero-D-galacto-non-2-enon ic acid, CALCIUM ION, ... | | Authors: | Fu, L, Wu, Y, Bi, Y, Zhang, S, Lv, X, Qi, J, Li, Y, Lu, X, Yan, J, Gao, G.F, Li, X. | | Deposit date: | 2016-05-15 | | Release date: | 2016-06-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses
J.Med.Chem., 59, 2016
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3O3K
 | | Crystal structure of AF1382 from Archaeoglobus fulgidus | | Descriptor: | Uncharacterized protein AF_1382 | | Authors: | Zhu, J.-Y, Zhao, M, Fu, Z.-Q, Yang, H, Chang, J, Xu, H, Chen, L, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2010-07-24 | | Release date: | 2010-08-04 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the Archaeoglobus fulgidus orphan ORF AF1382 determined by sulfur SAD from a moderately diffracting crystal.
Acta Crystallogr.,Sect.D, 68, 2012
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1RWE
 | | Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues | | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | | Authors: | Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A. | | Deposit date: | 2003-12-16 | | Release date: | 2005-02-15 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
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5YMV
 | | Crystal structure of 9-mer peptide from influenza virus in complex with BF2*1201 | | Descriptor: | ALA-VAL-LYS-GLY-VAL-GLY-THR-MET-VAL, Beta-2-microglobulin, Class I histocompatibility antigen, ... | | Authors: | Xiao, J, Xiang, W, Qi, J, Chai, Y, Liu, W.J, Gao, G.F. | | Deposit date: | 2017-10-22 | | Release date: | 2018-10-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.197 Å) | | Cite: | An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
J Immunol., 201, 2018
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5YMW
 | | Crystal structure of 8-mer peptide from Rous sarcoma virus in complex with BF2*1201 | | Descriptor: | Beta-2-microglobulin, Class I histocompatibility antigen, F10 alpha chain, ... | | Authors: | Xiao, J, Xiang, W, Qi, J, Chai, Y, Liu, W.J, Gao, G.F. | | Deposit date: | 2017-10-22 | | Release date: | 2018-10-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.997 Å) | | Cite: | An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
J Immunol., 201, 2018
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5YGI
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5XSG
 | | Ultrahigh resolution structure of FUS (37-42) SYSGYS determined by MicroED | | Descriptor: | RNA-binding protein FUS | | Authors: | Luo, F, Gui, X, Zhou, H, Li, D, Li, X, Liu, C. | | Deposit date: | 2017-06-14 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON CRYSTALLOGRAPHY (0.73 Å) | | Cite: | Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.
Nat. Struct. Mol. Biol., 25, 2018
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1VK1
 | | Conserved hypothetical protein from Pyrococcus furiosus Pfu-392566-001 | | Descriptor: | Conserved hypothetical protein, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | | Authors: | Shah, A, Liu, Z.J, Tempel, W, Chen, L, Lee, D, Yang, H, Chang, J, Zhao, M, Ng, J, Rose, J, Brereton, P.S, Izumi, M, Jenney Jr, F.E, Poole II, F.L, Shah, C, Sugar, F.J, Adams, M.W.W, Richardson, D.C, Richardson, J.S, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-04-13 | | Release date: | 2004-08-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | (NZ)CH...O contacts assist crystallization of a ParB-like nuclease.
Bmc Struct.Biol., 7, 2007
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7WCY
 | | Crystal Structure of H-2Kb with Cryptosporidium parvum gp40/15 epitope | | Descriptor: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Wang, Y.L, Gao, M.H, Zhang, L.X, Fan, S.H. | | Deposit date: | 2021-12-20 | | Release date: | 2022-12-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural Analyses of a Dominant Cryptosporidium parvum Epitope Presented by H-2K b Offer New Options To Combat Cryptosporidiosis.
Mbio, 14, 2023
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7CLD
 | | Crystal structure of T2R-TTL-Cevipabulin complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, CALCIUM ION, ... | | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | Deposit date: | 2020-07-20 | | Release date: | 2021-07-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.611 Å) | | Cite: | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
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7DP8
 | | Crystal structure of T2R-TTL-Cevipabulin-eribulin complex | | Descriptor: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... | | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | | Deposit date: | 2020-12-18 | | Release date: | 2021-07-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.446 Å) | | Cite: | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
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7CLF
 | | PigF with SAH | | Descriptor: | ACETATE ION, Methyltransferase domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Qiu, S, Xu, D, Han, N, Sun, B, Ran, T, Wang, W. | | Deposit date: | 2020-07-20 | | Release date: | 2021-07-28 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.982 Å) | | Cite: | Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism.
Iucrj, 9, 2022
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7CLU
 | | PigF with SAH | | Descriptor: | ACETATE ION, GLYCEROL, Methyltransferase domain-containing protein | | Authors: | Qiu, S, Xu, D, Han, N, Sun, B, Ran, T, Wang, W. | | Deposit date: | 2020-07-22 | | Release date: | 2021-07-28 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of PigF, an O-methyltransferase involved in the prodigiosin synthetic pathway, reveal an induced-fit substrate-recognition mechanism.
Iucrj, 9, 2022
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